You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
STAP1
Signal-transducing adaptor protein 1

Protein Summary
Description
In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC. The protein encoded by this gene contains a proline-rich region, a pleckstrin homology (PH) domain, and a region in the carboxy terminal half with similarity to the Src Homology 2 (SH2) domain. This protein is a substrate of tyrosine-protein kinase Tec, and its interaction with tyrosine-protein kinase Tec is phosphorylation-dependent. This protein is thought to participate in a positive feedback loop by upregulating the activity of tyrosine-protein kinase Tec. Variants of this gene have been associated with autosomal-dominant hypercholesterolemia (ADH), which is characterized by elevated low-density lipoprotein cholesterol levels and in increased risk of coronary vascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265404
  • ENSP00000265404
  • ENSG00000035720
  • ENST00000396225
  • ENSP00000379527

Symbol
  • BRDG1
  • BRDG1
  • STAP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
tissue sample
0.7
microRNA
0.68
PubMedID
0.58
tissue
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.96   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 207   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.96   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: pid
Signaling events mediated by Stem cell factor receptor (c-Kit)
PathwayCommons: netpath
KitReceptor
PathwayCommons: netpath
BCR
Name
Explore in Pharos
Explore in Source
Signaling events mediated by Stem cell factor receptor (c-Kit)
KitReceptor
BCR
Gene Ontology Terms (26)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Non-traceable Author Statement (NAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (42)
1 – 10 of 42
SH3KBP1
Tbio
Family: Enzyme
Novelty: 0.01467085
p_int: 0.999999965
p_ni: 3.5e-8
p_wrong: 1e-9
Score: 0.891
Data Source: BioPlex,STRINGDB
CD2AP
Tbio
Novelty: 0.00036564
p_int: 0.999923206
p_ni: 0.000076794
Score: 0.866
Data Source: BioPlex,STRINGDB
SULT1A1
Tbio
Family: Enzyme
Novelty: 0.00274079
p_int: 0.998070648
p_ni: 0.001929352
Score: 0.309
Data Source: BioPlex,STRINGDB
CCND3
Tchem
Novelty: 0.002875
p_int: 0.968740707
p_ni: 0.001726261
p_wrong: 0.029533033
Score: 0.237
Data Source: BioPlex,STRINGDB
SCPEP1
Tbio
Family: Enzyme
Novelty: 0.16064257
p_int: 0.955047382
p_ni: 9.9e-8
p_wrong: 0.044952519
Data Source: BioPlex
KIT
Tclin
Family: Kinase
Novelty: 0.00013951
Score: 0.941
Data Source: STRINGDB
STAT5A
Tchem
Family: TF
Novelty: 0.00091229
Score: 0.911
Data Source: STRINGDB
KITLG
Tbio
Novelty: 0.00051952
Score: 0.9
Data Source: STRINGDB
CAPZB
Tbio
Novelty: 0.04913074
Score: 0.86
Data Source: STRINGDB
BMX
Tchem
Family: Kinase
Novelty: 0.00500157
Score: 0.751
Data Source: STRINGDB
Publication Statistics
PubMed Score  3.96

PubMed score by year
PubTator Score  8.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer