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Tbio
STAP1
Signal-transducing adaptor protein 1

Protein Summary
Description
In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC. The protein encoded by this gene contains a proline-rich region, a pleckstrin homology (PH) domain, and a region in the carboxy terminal half with similarity to the Src Homology 2 (SH2) domain. This protein is a substrate of tyrosine-protein kinase Tec, and its interaction with tyrosine-protein kinase Tec is phosphorylation-dependent. This protein is thought to participate in a positive feedback loop by upregulating the activity of tyrosine-protein kinase Tec. Variants of this gene have been associated with autosomal-dominant hypercholesterolemia (ADH), which is characterized by elevated low-density lipoprotein cholesterol levels and in increased risk of coronary vascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265404
  • ENSP00000265404
  • ENSG00000035720
  • ENST00000396225
  • ENSP00000379527

Symbol
  • BRDG1
  • BRDG1
  • STAP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
tissue sample
0.7
microRNA
0.68
PubMedID
0.58
tissue
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.02   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 207   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.02   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (42)
SH3KBP1
Tbio
Family:  Enzyme
Novelty:  0.01454593
p_int:  0.999999965
p_ni:  3.5e-8
p_wrong:  1e-9
Score:  0.891
Data Source:  BioPlex,STRINGDB
CD2AP
Tbio
Novelty:  0.00603034
p_int:  0.999923206
p_ni:  0.000076794
Score:  0.866
Data Source:  BioPlex,STRINGDB
SULT1A1
Tchem
Family:  Enzyme
Novelty:  0.00238409
p_int:  0.998070648
p_ni:  0.001929352
Score:  0.309
Data Source:  BioPlex,STRINGDB
CCND3
Tchem
Novelty:  0.00223085
p_int:  0.968740707
p_ni:  0.001726261
p_wrong:  0.029533033
Score:  0.237
Data Source:  BioPlex,STRINGDB
SCPEP1
Tbio
Family:  Enzyme
Novelty:  0.08603794
p_int:  0.955047382
p_ni:  9.9e-8
p_wrong:  0.044952519
Data Source:  BioPlex
KIT
Tclin
Family:  Kinase
Novelty:  0.00011237
Score:  0.941
Data Source:  STRINGDB
STAT5A
Tchem
Family:  TF
Novelty:  0.00074026
Score:  0.911
Data Source:  STRINGDB
KITLG
Tbio
Novelty:  0.00036337
Score:  0.9
Data Source:  STRINGDB
CAPZB
Tbio
Novelty:  0.03509224
Score:  0.86
Data Source:  STRINGDB
BMX
Tchem
Family:  Kinase
Novelty:  0.00383533
Score:  0.751
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: pid
Signaling events mediated by Stem cell factor receptor (c-Kit)
PathwayCommons: netpath
KitReceptor
PathwayCommons: netpath
BCR
Name
Explore in Pharos
Explore in Source
Signaling events mediated by Stem cell factor receptor (c-Kit)
KitReceptor
BCR
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Non-traceable Author Statement (NAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
signal transducing adaptor family member 1
VGNC:691
471228
Macaque
signal transducing adaptor family member 1
711834
Mouse
MGI:1926193
56792
Rat
RGD:1311584
305269
Dog
signal transducing adaptor family member 1
VGNC:46878
482171
Species
Name
OMA
EggNOG
Inparanoid
Chimp
signal transducing adaptor family member 1
Macaque
signal transducing adaptor family member 1
Mouse
Rat
Dog
signal transducing adaptor family member 1
Publication Statistics
PubMed Score 9.02
PubMed score by year
PubTator Score 8.30
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title