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Tchem
CLEC4E
C-type lectin domain family 4 member E

Protein Summary
Description
A calcium-dependent lectin that acts as a pattern recognition receptor of the innate immune system. Recognizes damage-associated molecular patterns (DAMPs) of abnormal self and pathogen-associated molecular patterns (PAMPs) of bacteria and fungi (PubMed:18509109, PubMed:23602766). The PAMPs notably include mycobacterial trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid with potent adjuvant immunomodulatory functions (PubMed:23602766, PubMed:24101491). Interacts with signaling adapter Fc receptor gamma chain/FCER1G to form a functional complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. Specifically recognizes alpha- ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299663
  • ENSP00000299663
  • ENSG00000166523

Symbol
  • CLECSF9
  • MINCLE
  • MINCLE
  • CLECSF9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.83
small molecule perturbation
0.64
cell line
0.59
phenotype
0.57
tissue sample
0.57


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.87   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 269   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.87   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
GlcC14C18
chemical structure image
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-type lectin domain family 4 member E
VGNC:12894
735637
Mouse
MGI:1861232
56619
Rat
RGD:1359298
450223
Dog
C-type lectin domain family 4 member E
611538
Horse
C-type lectin domain family 4 member E
VGNC:16605
100060570
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-type lectin domain family 4 member E
Mouse
Rat
Dog
C-type lectin domain family 4 member E
Horse
C-type lectin domain family 4 member E
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9ULY5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
C-type lectin receptors (CLRs) (R-HSA-5621481)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
C-type lectin receptors (CLRs)
Reactome
Dectin-2 family
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
C-type lectin receptors (CLRs)
Dectin-2 family
Immune System
Innate Immune System
Gene Ontology Terms (11)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (57)
1 – 10 of 57
RNF166
Tdark
Novelty: 0.71460884
p_int: 0.997174551
p_ni: 0.002796402
p_wrong: 0.000029046
Score: 0.189
Data Source: BioPlex,STRINGDB
SFXN3
Tbio
Novelty: 0.18698456
p_int: 0.988671752
p_ni: 0.008538915
p_wrong: 0.002789333
Score: 0.212
Data Source: BioPlex,STRINGDB
TUBB3
Tclin
Novelty: 0.00195963
p_int: 0.965357696
p_ni: 0.034642304
Data Source: BioPlex
SYK
Tclin
Family: Kinase
Novelty: 0.00058994
Score: 0.97
Data Source: Reactome,STRINGDB
FCER1G
Tbio
Novelty: 0.00783146
Score: 0.965
Data Source: Reactome,STRINGDB
CLEC6A
Tbio
Novelty: 0.01228914
Score: 0.923
Data Source: STRINGDB
LYN
Tclin
Family: Kinase
Novelty: 0.00097393
Score: 0.917
Data Source: Reactome,STRINGDB
PLCG2
Tchem
Family: Enzyme
Novelty: 0.00294726
Score: 0.907
Data Source: Reactome,STRINGDB
FYN
Tclin
Family: Kinase
Novelty: 0.00072167
Score: 0.903
Data Source: Reactome,STRINGDB
TLR2
Tchem
Novelty: 0.00023242
Score: 0.806
Data Source: STRINGDB
Publication Statistics
PubMed Score  163.87

PubMed score by year
PubTator Score  33.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer