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Tclin
CA14
Carbonic anhydrase 14

Protein Summary
Description
Reversible hydration of carbon dioxide. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XIV is predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different physiologic roles. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369111
  • ENSP00000358107
  • ENSG00000118298
  • ENST00000647854
  • ENSP00000498013

Symbol
  • CAXiV
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.89
gene perturbation
0.82
disease perturbation
0.68
histone modification site profile
0.63
transcription factor
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.2   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.2   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 402
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 14
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
circadian rhythm
1
1
0
1.1
52
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
circadian rhythm
0
1.1
52
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carbonic anhydrase 14
VGNC:9849
469479
Macaque
carbonic anhydrase 14
706360
Mouse
MGI:1344341
23831
Rat
RGD:1599277
791259
Dog
carbonic anhydrase 14
VGNC:38609
100855809
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carbonic anhydrase 14
Macaque
carbonic anhydrase 14
Mouse
Rat
Dog
carbonic anhydrase 14
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9ULX7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Reversible hydration of carbon dioxide
Name
Explore in Pharos
Explore in Source
Metabolism
Reversible hydration of carbon dioxide
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (77)
1 – 10 of 77
CIP2A
Tbio
Novelty: 0.00992381
p_int: 0.999964779
p_ni: 0.000035221
Data Source: BioPlex
SLC38A7
Tdark
Family: Transporter
Novelty: 0.24353276
p_int: 0.999944619
p_ni: 0.000048157
p_wrong: 0.000007224
Data Source: BioPlex
ATR
Tchem
Family: Kinase
Novelty: 0.00196978
p_int: 0.999908108
p_ni: 0.000091892
Data Source: BioPlex
NF1
Tbio
Novelty: 0.00019092
p_int: 0.999361013
p_ni: 0.000638985
p_wrong: 2e-9
Data Source: BioPlex
DNM1L
Tbio
Novelty: 0.00151314
p_int: 0.996576656
p_ni: 0.003226159
p_wrong: 0.000197185
Data Source: BioPlex
PEX19
Tbio
Novelty: 0.00605342
p_int: 0.995348645
p_ni: 0.004651355
Data Source: BioPlex
EIF2B4
Tbio
Novelty: 0.05080792
p_int: 0.992883128
p_ni: 0.007116872
Data Source: BioPlex
EIF2B5
Tbio
Novelty: 0.0102209
p_int: 0.991481416
p_ni: 0.008518519
p_wrong: 6.5e-8
Score: 0.219
Data Source: BioPlex,STRINGDB
XPO6
Tbio
Novelty: 0.03229708
p_int: 0.989910005
p_ni: 0.010089995
Data Source: BioPlex
EIF2B3
Tbio
Novelty: 0.04963646
p_int: 0.98989503
p_ni: 0.01010497
Data Source: BioPlex
Publication Statistics
PubMed Score  111.20

PubMed score by year
PubTator Score  48.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer