Protein Summary
Reversible hydration of carbon dioxide. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XIV is predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different physiologic roles. [provided by RefSeq, Jul 2008]
- ENST00000369111
- ENSP00000358107
- ENSG00000118298
- ENST00000647854
- ENSP00000498013
- CAXiV
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.89 | ||
gene perturbation | 0.82 | ||
disease perturbation | 0.68 | ||
histone modification site profile | 0.63 | ||
transcription factor | 0.55 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 112.67 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 177 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 112.67 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 177 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 549
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 16
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (16)
Active Ligands (549)
Protein-Protein Interactions (77)
SLC38A7
Family: Transporter
Novelty: 0.24353276
p_int: 0.999944619
p_ni: 0.000048157
p_wrong: 0.000007224
Data Source: BioPlex
ATR
Family: Kinase
Novelty: 0.00196978
p_int: 0.999908108
p_ni: 0.000091892
Data Source: BioPlex
DNM1L
Novelty: 0.00151314
p_int: 0.996576656
p_ni: 0.003226159
p_wrong: 0.000197185
Data Source: BioPlex
EIF2B5
Novelty: 0.0102209
p_int: 0.991481416
p_ni: 0.008518519
p_wrong: 6.5e-8
Score: 0.219
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (2)
KEGG (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Reversible hydration of carbon dioxide | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Reversible hydration of carbon dioxide | ||||
Viral Interactions (0)
Gene Ontology Terms (5)
Functions (2)
Components (2)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (27)
Items per page:
1 – 5 of 27
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
chronotype measurement | 2 | 5 | 3 | 1 | 94.2 | ||||
glomerular filtration rate | 4 | 4 | 4 | 87.4 | |||||
circadian rhythm | 5 | 3 | 3 | 1.1 | 83.6 | ||||
red blood cell distribution width | 2 | 2 | 2 | 68.8 | |||||
platelet count | 2 | 2 | 2 | 67.4 | |||||
Items per page:
1 – 5 of 27
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
chronotype measurement | 3 | 1 | 94.2 | ||||
glomerular filtration rate | 4 | 87.4 | |||||
circadian rhythm | 3 | 1.1 | 83.6 | ||||
red blood cell distribution width | 2 | 68.8 | |||||
platelet count | 2 | 67.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | carbonic anhydrase 14 | VGNC:9849 | 469479 | |||||
Macaque | carbonic anhydrase 14 | 706360 | ||||||
Mouse | MGI:1344341 | 23831 | ||||||
Rat | RGD:1599277 | 791259 | ||||||
Dog | carbonic anhydrase 14 | VGNC:38609 | 100855809 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | carbonic anhydrase 14 | |||||
Macaque | carbonic anhydrase 14 | |||||
Mouse | ||||||
Rat | ||||||
Dog | carbonic anhydrase 14 | |||||
Publication Statistics
PubMed Score 112.67
PubMed score by year
PubTator Score 48.59
PubTator score by year
Related Publications
Text Mined References (16)
GeneRif Annotations (4)
Items per page:
0 of 0
PMID | Year | Title |
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