Tclin CA14 Carbonic anhydrase 14

Protein Summary

Description

Reversible hydration of carbon dioxide. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XIV is predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different physiologic roles. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9ULX7
• Q5TB24
• Q8NCF4

Gene Name

• CA14

Ensembl ID

• ENST00000369111
• ENSP00000358107
• ENSG00000118298
• ENST00000647854
• ENSP00000498013

Symbol

• CAXiV

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.89
gene perturbation	0.82
disease perturbation	0.68
histone modification site profile	0.63
transcription factor	0.55

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.74   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 177   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.74   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 402

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 14

Approved Drugs (14)

Explore Approved Drugs

1 – 10 of 14

acetazolamide

CA14Tclin Enzyme

Ki: 8.24

ethoxzolamide

CA14Tclin Enzyme

INHIBITOR Ki: 8.6

celecoxib

CA14Tclin Enzyme

Ki: 6.16

dichlorphenamide

CA14Tclin Enzyme

Ki: 6.46

dorzolamide

CA14Tclin Enzyme

Ki: 7.82000017

brinzolamide

CA14Tclin Enzyme

Ki: 4.1500001

imatinib

CA14Tclin Enzyme

Ki: 6.33

valdecoxib

CA14Tclin Enzyme

Ki: 6.97

nilotinib

CA14Tclin Enzyme

Ki: 6.65

zoledronic acid

CA14Tclin Enzyme

IC50: 7.04

Active Ligands (402)

Explore Active Ligands

1 – 10 of 402

CHEMBL19

CA14Tclin Enzyme

Ki: 7.37

CHEMBL77517

CA14Tclin Enzyme

Ki: 6.98

CHEMBL268439

CA14Tclin Enzyme

Ki: 7.89

CHEMBL73962

CA14Tclin Enzyme

Ki: 7.48

CHEMBL6633

CA14Tclin Enzyme

Ki: 7.05

CHEMBL7146

CA14Tclin Enzyme

Ki: 7.12

CHEMBL265674

CA14Tclin Enzyme

Ki: 6.55

CHEMBL6853

CA14Tclin Enzyme

Ki: 6.75

CHEMBL414

CA14Tclin Enzyme

Ki: 6.11

CHEMBL266240

CA14Tclin Enzyme

Ki: 6.24

Protein Data Bank (2)

1 – 2 of 2

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (4)

Reactome (2)

KEGG (2)

Metabolism (R-HSA-1430728)

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Items per page:

5

1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Reversible hydration of carbon dioxide	12 targets	R-HSA-1475029

Name	Explore in Pharos	Explore in Source
Metabolism	2112 targets	R-HSA-1430728
Reversible hydration of carbon dioxide	12 targets	R-HSA-1475029

Gene Ontology Terms (5)

Functions (2)

Components (2)

Processes (1)

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
carbonate dehydratase activity	Traceable Author Statement (TAS)	Reactome
zinc ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (77)

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1 – 10 of 77

• See Interactions on String-DB

CIP2A

Tbio

Novelty: 0.00948462

p_int: 0.999964779

p_ni: 0.000035221

Data Source: BioPlex

SLC38A7

Tdark

Family: Transporter

Novelty: 0.30036308

p_int: 0.999944619

p_ni: 0.000048157

p_wrong: 0.000007224

Data Source: BioPlex

ATR

Tchem

Family: Kinase

Novelty: 0.00246592

p_int: 0.999908108

p_ni: 0.000091892

Data Source: BioPlex

NF1

Tbio

Novelty: 0.00021961

p_int: 0.999361013

p_ni: 0.000638985

p_wrong: 2e-9

Data Source: BioPlex

DNM1L

Tbio

Novelty: 0.00184129

p_int: 0.996576656

p_ni: 0.003226159

p_wrong: 0.000197185

Data Source: BioPlex

PEX19

Tbio

Novelty: 0.00469515

p_int: 0.995348645

p_ni: 0.004651355

Data Source: BioPlex

EIF2B4

Tbio

Novelty: 0.07295839

p_int: 0.992883128

p_ni: 0.007116872

Data Source: BioPlex

EIF2B5

Tbio

Novelty: 0.01114599

p_int: 0.991481416

p_ni: 0.008518519

p_wrong: 6.5e-8

Score: 0.219

Data Source: BioPlex,STRINGDB

XPO6

Tbio

Novelty: 0.0244998

p_int: 0.989910005

p_ni: 0.010089995

Data Source: BioPlex

EIF2B3

Tbio

Novelty: 0.05806987

p_int: 0.98989503

p_ni: 0.01010497

Data Source: BioPlex

Publication Statistics

PubMed Score  141.74

PubMed score by year

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PubTator Score  48.59

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MLFSALLLEVIWILAADGGQHWTYEGPHGQDHWPASYPECGNNAQSPIDIQTDSVTFDPDLPALQPHGYD

1-70

QPGTEPLDLHNNGHTVQLSLPSTLYLGGLPRKYVAAQLHLHWGQKGSPGGSEHQINSEATFAELHIVHYD

70-140

SDSYDSLSEAAERPQGLAVLGILIEVGETKNIAYEHILSHLHEVRHKDQKTSVPPFNLRELLPKQLGQYF

140-210

RYNGSLTTPPCYQSVLWTVFYRRSQISMEQLEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQ

210-280

AGSSYTTGEMLSLGVGILVGCLCLLLAVYFIARKIRKKRLENRKSVVFTSAQATTEA

280-337

MLFSALLLEVIWILAADGGQHWTYEGPHGQDHWPASYPECGNNAQSPIDIQTDSVTFDPDLPALQPHGYDQPGTEPLDLHNNGHTVQLSLPSTLYLGGLPRKYVAAQLHLHWGQKGSPGGSEHQINSEATFAELHIVHYDSDSYDSLSEAAERPQGLAVLGILIEVGETKNIAYEHILSHLHEVRHKDQKTSVPPFNLRELLPKQLGQYFRYNGSLTTPPCYQSVLWTVFYRRSQISMEQLEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQAGSSYTTGEMLSLGVGILVGCLCLLLAVYFIARKIRKKRLENRKSVVFTSAQATTEA

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Uniprot Keyword

3D-structure
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Disulfide bond
Glycoprotein
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Membrane
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