Tclin CA14 Carbonic anhydrase 14

Protein Summary

Description

Reversible hydration of carbon dioxide. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XIV is predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different physiologic roles. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9ULX7
• Q5TB24
• Q8NCF4

Gene Name

• CA14

Ensembl ID

• ENST00000369111
• ENSP00000358107
• ENSG00000118298
• ENST00000647854
• ENSP00000498013

Symbol

• CAXiV

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.89
gene perturbation	0.82
disease perturbation	0.68
histone modification site profile	0.63
transcription factor	0.55

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.2   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 177   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.2   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 402

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 14

Approved Drugs (14)

Explore Approved Drugs

1 – 10 of 14

imatinib

CA14Tclin Enzyme

Ki : 6.33

nilotinib

CA14Tclin Enzyme

Ki : 6.65

celecoxib

CA14Tclin Enzyme

Ki : 6.16

furosemide

CA14Tclin Enzyme

Ki : 7.28

acetazolamide

CA14Tclin Enzyme

Ki : 8.24

ethoxzolamide

CA14Tclin Enzyme

INHIBITOR Ki : 8.6

lacosamide

CA14Tclin Enzyme

Ki : 6.33

dichlorphenamide

CA14Tclin Enzyme

Ki : 6.46

dorzolamide

CA14Tclin Enzyme

Ki : 7.82000017

brinzolamide

CA14Tclin Enzyme

Ki : 4.1500001

Active Ligands (402)

Explore Active Ligands

1 – 10 of 402

CHEMBL2333417

CA14Tclin Enzyme

Kd : 8.3

CHEMBL19

CA14Tclin Enzyme

Ki : 7.37

CHEMBL286738

CA14Tclin Enzyme

Ki : 6.12

CHEMBL2333416

CA14Tclin Enzyme

Kd : 8.89

CHEMBL1956579

CA14Tclin Enzyme

Ki : 7.8

CHEMBL1209039

CA14Tclin Enzyme

Ki : 8.29

CHEMBL71611

CA14Tclin Enzyme

Ki : 9.05

CHEMBL1956578

CA14Tclin Enzyme

Ki : 7.32

CHEMBL191045

CA14Tclin Enzyme

Ki : 8.03

CHEMBL1209038

CA14Tclin Enzyme

Ki : 8.12

GWAS Traits (1)

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5

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
circadian rhythm	EFO_0004354	1	1	0	1.1	52

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
circadian rhythm	EFO_0004354	0	1.1	52

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Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	carbonic anhydrase 14	VGNC:9849	469479
Macaque	carbonic anhydrase 14		706360
Mouse	carbonic anhydrase 14	MGI:1344341	23831
Rat	carbonic anhydrase 14	RGD:1599277	791259
Dog	carbonic anhydrase 14	VGNC:38609	100855809

Species	Name	OMA	EggNOG	Inparanoid
Chimp	carbonic anhydrase 14
Macaque	carbonic anhydrase 14
Mouse	carbonic anhydrase 14
Rat	carbonic anhydrase 14
Dog	carbonic anhydrase 14

Protein Structure (2 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9ULX7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (4)

Reactome (2)

KEGG (2)

Metabolism (R-HSA-1430728)

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Find Similar Targets

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Reversible hydration of carbon dioxide	12 targets	R-HSA-1475029

Name	Explore in Pharos	Explore in Source
Metabolism	2112 targets	R-HSA-1430728
Reversible hydration of carbon dioxide	12 targets	R-HSA-1475029

Gene Ontology Terms (5)

Functions (2)

Components (2)

Processes (1)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
carbonate dehydratase activity	Traceable Author Statement (TAS)	Reactome
zinc ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (77)

Explore Interacting Targets

1 – 10 of 77

• See Interactions on String-DB

CIP2A

Tbio

Novelty: 0.00992381

p_int: 0.999964779

p_ni: 0.000035221

Data Source: BioPlex

SLC38A7

Tdark

Family: Transporter

Novelty: 0.24353276

p_int: 0.999944619

p_ni: 0.000048157

p_wrong: 0.000007224

Data Source: BioPlex

ATR

Tchem

Family: Kinase

Novelty: 0.00196978

p_int: 0.999908108

p_ni: 0.000091892

Data Source: BioPlex

NF1

Tbio

Novelty: 0.00019092

p_int: 0.999361013

p_ni: 0.000638985

p_wrong: 2e-9

Data Source: BioPlex

DNM1L

Tbio

Novelty: 0.00151314

p_int: 0.996576656

p_ni: 0.003226159

p_wrong: 0.000197185

Data Source: BioPlex

PEX19

Tbio

Novelty: 0.00605342

p_int: 0.995348645

p_ni: 0.004651355

Data Source: BioPlex

EIF2B4

Tbio

Novelty: 0.05080792

p_int: 0.992883128

p_ni: 0.007116872

Data Source: BioPlex

EIF2B5

Tbio

Novelty: 0.0102209

p_int: 0.991481416

p_ni: 0.008518519

p_wrong: 6.5e-8

Score: 0.219

Data Source: BioPlex,STRINGDB

XPO6

Tbio

Novelty: 0.03229708

p_int: 0.989910005

p_ni: 0.010089995

Data Source: BioPlex

EIF2B3

Tbio

Novelty: 0.04963646

p_int: 0.98989503

p_ni: 0.01010497

Data Source: BioPlex

Publication Statistics

PubMed Score  111.20

PubMed score by year

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PubTator Score  48.59

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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3D-structure
Complete proteome
Disulfide bond
Glycoprotein
Lyase
Membrane
Metal-binding
Phosphoprotein
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Signal

GWAS Trait Find Similar Targets

circadian rhythm