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Tbio
NOB1
RNA-binding protein NOB1

Protein Summary
Description
May play a role in mRNA degradation. In yeast, over 200 protein and RNA cofactors are required for ribosome assembly, and these are generally conserved in eukaryotes. These factors orchestrate modification and cleavage of the initial 35S precursor rRNA transcript into the mature 18S, 5.8S, and 25S rRNAs, folding of the rRNA, and binding of ribosomal proteins and 5S RNA. Nob1 is involved in pre-rRNA processing. In a late cytoplasmic processing step, Nob1 cleaves a 20S rRNA intermediate at cleavage site D to produce the mature 18S rRNA (Lamanna and Karbstein, 2009 [PubMed 19706509]).[supplied by OMIM, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268802
  • ENSP00000268802
  • ENSG00000141101

Symbol
  • ART4
  • NOB1P
  • PSMD8BP1
  • ART-4
  • NOB1P
  • MST158
  • MSTP158
  • PSMD8BP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.71
transcription factor binding site profile
0.71
interacting protein
0.67
tissue
0.67
ligand (protein) perturbation
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.11   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.11   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (273)
HLA-DPA1
Tbio
Novelty:  0.01080446
p_int:  0.999990713
p_ni:  0.000009287
Data Source:  BioPlex
PNO1
Tbio
Novelty:  0.05311566
p_int:  0.999986493
p_ni:  0.000013507
Score:  0.999
Data Source:  BioPlex,STRINGDB
PRM2
Tbio
Novelty:  0.0050028
p_int:  0.999454056
p_ni:  0.00054592
p_wrong:  2.3e-8
Data Source:  BioPlex
RPS14
Tbio
Novelty:  0.00576737
p_int:  0.999274442
p_ni:  0.000725558
Score:  0.994
Data Source:  BioPlex,STRINGDB
RPS16
Tbio
Novelty:  0.00261983
p_int:  0.999035168
p_ni:  0.000964825
p_wrong:  7e-9
Score:  0.983
Data Source:  BioPlex,STRINGDB
DNA2
Tbio
Family:  Enzyme
Novelty:  0.00195682
p_int:  0.997638542
p_ni:  0.002361175
p_wrong:  2.83e-7
Score:  0.22
Data Source:  BioPlex,STRINGDB
BYSL
Tbio
Novelty:  0.01919968
p_int:  0.992738638
p_ni:  0.007261362
Score:  0.999
Data Source:  BioPlex,STRINGDB
RPS2
Tbio
Novelty:  0.00412313
p_int:  0.991144159
p_ni:  0.008855841
Score:  0.987
Data Source:  BioPlex,STRINGDB
RPS13
Tbio
Novelty:  0.0019983
p_int:  0.990109904
p_ni:  0.009889201
p_wrong:  8.95e-7
Score:  0.985
Data Source:  BioPlex,STRINGDB
KLHL22
Tbio
Novelty:  0.24456252
p_int:  0.985477096
p_ni:  0.014522904
Score:  0.157
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
2
2
2
84.5
glomerular filtration rate
3
3
2
5.7
78.9
visceral adipose tissue measurement
1
1
1
74.4
body height
1
1
1
72.3
chloride measurement
1
1
1
70.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
2
84.5
glomerular filtration rate
2
5.7
78.9
visceral adipose tissue measurement
1
74.4
body height
1
72.3
chloride measurement
1
70.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NIN1 (RPN12) binding protein 1 homolog
VGNC:9093
468013
Macaque
NIN1/PSMD8 binding protein 1 homolog
705344
Mouse
MGI:1914869
67619
Rat
RGD:735222
291996
Dog
NIN1 (RPN12) binding protein 1 homolog
VGNC:43872
489733
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NIN1 (RPN12) binding protein 1 homolog
Macaque
NIN1/PSMD8 binding protein 1 homolog
Mouse
Rat
Dog
NIN1 (RPN12) binding protein 1 homolog
Publication Statistics
PubMed Score 87.11
PubMed score by year
PubTator Score 45.23
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title