Tbio NOB1 RNA-binding protein NOB1

Protein Summary

Description

May play a role in mRNA degradation. In yeast, over 200 protein and RNA cofactors are required for ribosome assembly, and these are generally conserved in eukaryotes. These factors orchestrate modification and cleavage of the initial 35S precursor rRNA transcript into the mature 18S, 5.8S, and 25S rRNAs, folding of the rRNA, and binding of ribosomal proteins and 5S RNA. Nob1 is involved in pre-rRNA processing. In a late cytoplasmic processing step, Nob1 cleaves a 20S rRNA intermediate at cleavage site D to produce the mature 18S rRNA (Lamanna and Karbstein, 2009 [PubMed 19706509]).[supplied by OMIM, Nov 2010]

Uniprot Accession IDs

• Q9ULX3
• Q7L6B7
• Q7M4M4
• Q7Z4B5
• Q9NWB0

Gene Name

• NOB1

Ensembl ID

• ENST00000268802
• ENSP00000268802
• ENSG00000141101

Symbol

• ART4
• NOB1P
• PSMD8BP1
• ART-4
• NOB1P
• MST158
• MSTP158
• PSMD8BP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.71
transcription factor binding site profile	0.71
interacting protein	0.67
tissue	0.67
ligand (protein) perturbation	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.49   (req: < 5)

Gene RIFs: 38   (req: <= 3)

Antibodies: 214   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.49   (req: >= 5)

Gene RIFs: 38   (req: > 3)

Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0