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Tchem
PADI3
Protein-arginine deiminase type-3

Protein Summary
Description
Catalyzes the deimination of arginine residues of proteins. This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type III enzyme modulates hair structural proteins, such as filaggrin in the hair follicle and trichohyalin in the inner root sheath, during hair follicle formation. Together with the type I enzyme, this enzyme may also play a role in terminal differentiation of the epidermis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375460
  • ENSP00000364609
  • ENSG00000142619
  • ENST00000625769
  • ENSP00000486702
  • ENSG00000280549

Symbol
  • PAD3
  • PDI3
  • PAD3
  • PDI3
  • UHS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.77
protein domain
0.73
phenotype
0.65
gene perturbation
0.49
microRNA
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.44   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.44   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (36)
PADI4
Tchem
Family:  Enzyme
Novelty:  0.0024252
p_int:  1
Score:  0.435
Data Source:  BioPlex,STRINGDB
FBXL4
Tbio
Novelty:  0.04286856
p_int:  0.999932607
p_ni:  0.000067365
p_wrong:  2.8e-8
Data Source:  BioPlex
PADI1
Tchem
Family:  Enzyme
Novelty:  0.01388854
p_int:  0.999870215
p_ni:  0.000129785
Score:  0.439
Data Source:  BioPlex,STRINGDB
NFKB1
Tclin
Family:  TF
Novelty:  0.00198195
p_int:  0.999727307
p_ni:  0.000272684
p_wrong:  8e-9
Score:  0.179
Data Source:  BioPlex,STRINGDB
PYHIN1
Tbio
Novelty:  0.06662677
p_int:  0.999636764
p_ni:  0.000359703
p_wrong:  0.000003533
Data Source:  BioPlex
RAB11B
Tbio
Family:  Enzyme
Novelty:  0.00557558
p_int:  0.999276709
p_ni:  0.000723287
p_wrong:  4e-9
Data Source:  BioPlex
KIF3A
Tbio
Novelty:  0.00555124
p_int:  0.999150888
p_ni:  0.0008491
p_wrong:  1.2e-8
Data Source:  BioPlex
OAZ3
Tbio
Family:  Enzyme
Novelty:  0.02374168
p_int:  0.999112229
p_ni:  0.000887758
p_wrong:  1.3e-8
Data Source:  BioPlex
MRPL38
Tdark
Novelty:  0.71587283
p_int:  0.99663014
p_ni:  0.002269286
p_wrong:  0.001100574
Data Source:  BioPlex
IL31RA
Tbio
Novelty:  0.00737445
p_int:  0.995527149
p_ni:  0.003503458
p_wrong:  0.000969393
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
4
4
4
93
vitamin D measurement
4
4
4
93
6
4
3
1.1
90.2
6
4
3
1.1
90.2
hair shape measurement
1
1
1
69.8
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
4
93
vitamin D measurement
4
93
3
1.1
90.2
3
1.1
90.2
hair shape measurement
1
69.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peptidyl arginine deiminase 3
VGNC:11596
469178
Mouse
MGI:1338891
18601
Rat
RGD:3289
29520
Dog
peptidyl arginine deiminase 3
VGNC:44236
478216
Horse
peptidyl arginine deiminase 3
VGNC:21129
100049897
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peptidyl arginine deiminase 3
Mouse
Rat
Dog
peptidyl arginine deiminase 3
Horse
peptidyl arginine deiminase 3
Publication Statistics
PubMed Score 89.44
PubMed score by year
PubTator Score 40.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title