Tbio RAB26 Ras-related protein Rab-26

Protein Summary

Description

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach. Plays a role in the secretion of amylase from acinar granules in the parotid gland. Members of the RAB protein family, including RAB26, are important regulators of vesicular fusion and trafficking. The RAB family of small G proteins regulates intercellular vesicle trafficking, including exocytosis, endocytosis, and recycling (summary by Seki et al., 2000 [PubMed 11043516]).[supplied by OMIM, Nov 2010]

Uniprot Accession IDs

• Q9ULW5
• B2RAA6
• Q3L6K5
• Q6NXS7

Gene Name

• RAB26

Ensembl ID

• ENST00000210187
• ENSP00000210187
• ENSG00000167964
• ENST00000541451
• ENSP00000441580

Symbol

• V46133

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.93
cellular component	0.71
transcription factor	0.66
transcription factor perturbation	0.61
virus perturbation	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.41   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 169   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.41   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0