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Tbio
ABT1
Activator of basal transcription 1

Protein Summary
Description
Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity). Basal transcription of genes by RNA polymerase II requires the interaction of TATA-binding protein (TBP) with the core region of class II promoters. Studies in mouse suggest that the protein encoded by this gene likely activates basal transcription from class II promoters by interaction with TBP and the class II promoter DNA. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274849
  • ENSP00000274849
  • ENSG00000146109

Symbol
  • Esf2
  • hABT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.95
histone modification site profile
0.91
microRNA
0.7
tissue sample
0.7
interacting protein
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.82   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.82   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (196)
E4F1
Tbio
Family:  TF
Novelty:  0.02192338
p_int:  0.999860528
p_ni:  0.000139472
Data Source:  BioPlex
NAP1L5
Tbio
Novelty:  0.10378595
p_int:  0.999594209
p_ni:  0.000405791
Score:  0.431
Data Source:  BioPlex,STRINGDB
PRDM5
Tbio
Family:  TF; Epigenetic
Novelty:  0.01689997
p_int:  0.998819129
p_ni:  0.001180871
Data Source:  BioPlex
CACNG5
Tdark
Family:  IC
Novelty:  0.52705448
p_int:  0.968500457
p_ni:  0.031499543
Data Source:  BioPlex
CA10
Tbio
Family:  Enzyme
Novelty:  0.01053152
p_int:  0.855618793
p_ni:  0.144381207
Score:  0.207
Data Source:  BioPlex,STRINGDB
H1FNT
Tdark
Novelty:  0.05593238
p_int:  0.795782185
p_ni:  0.204217815
Data Source:  BioPlex
CNBP
Tbio
Novelty:  0.00404247
p_int:  0.762507731
p_ni:  0.237492269
Score:  0.188
Data Source:  BioPlex,STRINGDB
ESF1
Tbio
Novelty:  0.03295863
Score:  0.995
Data Source:  STRINGDB
DDX49
Tbio
Family:  Enzyme
Novelty:  0.14100169
Score:  0.994
Data Source:  STRINGDB
DDX10
Tbio
Family:  Enzyme
Novelty:  0.03272208
Score:  0.98
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
3
3
90.2
self reported educational attainment
3
3
3
88.7
intelligence
3
7
4
6.7
88.2
liver iron measurement
1
1
1
82.1
BMI-adjusted hip circumference
2
4
5
81.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
90.2
self reported educational attainment
3
88.7
intelligence
4
6.7
88.2
liver iron measurement
1
82.1
BMI-adjusted hip circumference
5
81.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
activator of basal transcription 1
VGNC:2634
462499
Macaque
activator of basal transcription 1
700856
Mouse
MGI:1353636
30946
Rat
RGD:1310785
306960
Dog
activator of basal transcription 1
VGNC:37485
100856389
Species
Name
OMA
EggNOG
Inparanoid
Chimp
activator of basal transcription 1
Macaque
activator of basal transcription 1
Mouse
Rat
Dog
activator of basal transcription 1
Publication Statistics
PubMed Score 18.82
PubMed score by year
PubTator Score 2.58
PubTator score by year
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Related Publications
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PMID
Year
Title