Tbio FZD10 Frizzled-10

Protein Summary

Description

Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9ULW2
• Fz-10

Gene Name

• FZD10

Ensembl ID

• ENST00000229030
• ENSP00000229030
• ENSG00000111432

Symbol

• Fz10
• FzE7
• CD350
• FZ-10
• hFz10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.79
biological process	0.76
protein domain	0.73
tissue sample	0.67
interacting protein	0.6

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Frizzled-10

Protein / Receptor / G-protein Coupled Receptor / Frizzled-10

Protein / ... / Protease Inhibitor / Frizzled-10

DTO Classes

Protein / G-protein Coupled Receptor / Class F Frizzled-type / Frizzled Receptor / Frizzled-10

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.62   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 244   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.62   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 244   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0