Protein Summary
Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of sig ...more
- ENST00000229030
- ENSP00000229030
- ENSG00000111432
- Fz10
- FzE7
- CD350
- FZ-10
- hFz10
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
PubMedID | 0.79 | ||
biological process | 0.76 | ||
protein domain | 0.73 | ||
tissue sample | 0.67 | ||
interacting protein | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 42.69 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 244 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 42.69 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 244 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (112)
EVI5
Novelty: 0.05021983
p_int: 0.999998298
p_ni: 4.52e-7
p_wrong: 0.00000125
Score: 0.189
Data Source: BioPlex,STRINGDB
TMED8
Novelty: 1.41977071
p_int: 0.999951137
p_ni: 0.000048857
p_wrong: 6e-9
Data Source: BioPlex
GSTCD
Family: Enzyme
Novelty: 0.11613228
p_int: 0.999902658
p_ni: 0.000059762
p_wrong: 0.00003758
Score: 0.202
Data Source: BioPlex,STRINGDB
ATRIP
Novelty: 0.01415267
p_int: 0.999479821
p_ni: 0.000520177
p_wrong: 3e-9
Data Source: BioPlex
EVI5L
Novelty: 0.70769557
p_int: 0.997249611
p_ni: 0.00267351
p_wrong: 0.00007688
Data Source: BioPlex
VEZT
Novelty: 0.06274137
p_int: 0.994386569
p_ni: 0.00555189
p_wrong: 0.000061541
Data Source: BioPlex
NCAPD2
Novelty: 0.04960987
p_int: 0.988909101
p_ni: 0.011090736
p_wrong: 1.63e-7
Data Source: BioPlex
Nearest Tclin Targets (9)
Upstream (7)
Downstream (2)
1 – 5 of 7
Pathways (54)
Reactome (4)
KEGG (13)
PathwayCommons (30)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Class B/2 (Secretin family receptors) | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by GPCR | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Class B/2 (Secretin family receptors) | ||||
GPCR ligand binding | ||||
Signal Transduction | ||||
Signaling by GPCR | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (3)
Components (5)
Processes (9)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | WormBase | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
1 | 2 | 2 | 54.3 | ||||||
balding measurement | 2 | 1 | 2 | 40.6 | |||||
mathematical ability | 3 | 1 | 3 | 13.6 | |||||
2 | 1 | 1 | 1.2 | 12.2 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
2 | 54.3 | ||||||
balding measurement | 2 | 40.6 | |||||
mathematical ability | 3 | 13.6 | |||||
1 | 1.2 | 12.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | frizzled class receptor 10 | VGNC:5395 | 467160 | |||||
Macaque | frizzled class receptor 10 | 717812 | ||||||
Mouse | MGI:2136761 | 93897 | ||||||
Dog | frizzled class receptor 10 | VGNC:41029 | 486232 | |||||
Horse | frizzled class receptor 10 | VGNC:18170 | 100062909 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | frizzled class receptor 10 | |||||
Macaque | frizzled class receptor 10 | |||||
Mouse | ||||||
Dog | frizzled class receptor 10 | |||||
Horse | frizzled class receptor 10 | |||||
Publication Statistics
PubMed Score 42.69
PubMed score by year
PubTator Score 20.00
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (20)
GeneRif Annotations (5)
Items per page:
0 of 0
PMID | Year | Title |
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