Tbio FZD10 Frizzled-10

Protein Summary

Description

Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9ULW2
• Fz-10

Gene Name

• FZD10

Ensembl ID

• ENST00000229030
• ENSP00000229030
• ENSG00000111432

Symbol

• Fz10
• FzE7
• CD350
• FZ-10
• hFz10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.79
biological process	0.76
protein domain	0.73
tissue sample	0.67
interacting protein	0.6

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Frizzled-10

Protein / Receptor / G-protein Coupled Receptor / Frizzled-10

Protein / ... / Protease Inhibitor / Frizzled-10

DTO Classes

Protein / G-protein Coupled Receptor / Class F Frizzled-type / Frizzled Receptor / Frizzled-10

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.69   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 244   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.69   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 244   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (112)

Explore Interacting Targets

1 – 10 of 112

• See Interactions on String-DB

EVI5

Tbio

Novelty:  0.05021983

p_int:  0.999998298

p_ni:  4.52e-7

p_wrong:  0.00000125

Score:  0.189

Data Source:  BioPlex,STRINGDB

TMED8

Tdark

Novelty:  1.41977071

p_int:  0.999951137

p_ni:  0.000048857

p_wrong:  6e-9

Data Source:  BioPlex

GSTCD

Tbio

Family:  Enzyme

Novelty:  0.11613228

p_int:  0.999902658

p_ni:  0.000059762

p_wrong:  0.00003758

Score:  0.202

Data Source:  BioPlex,STRINGDB

VPS8

Tbio

Novelty:  0.05178496

p_int:  0.999484807

p_ni:  0.000515152

p_wrong:  4e-8

Data Source:  BioPlex

ATRIP

Tbio

Novelty:  0.01415267

p_int:  0.999479821

p_ni:  0.000520177

p_wrong:  3e-9

Data Source:  BioPlex

EVI5L

Tbio

Novelty:  0.70769557

p_int:  0.997249611

p_ni:  0.00267351

p_wrong:  0.00007688

Data Source:  BioPlex

VEZT

Tbio

Novelty:  0.06274137

p_int:  0.994386569

p_ni:  0.00555189

p_wrong:  0.000061541

Data Source:  BioPlex

RINT1

Tbio

Novelty:  0.04546291

p_int:  0.990265726

p_ni:  0.009734274

Data Source:  BioPlex

NCAPD2

Tbio

Novelty:  0.04960987

p_int:  0.988909101

p_ni:  0.011090736

p_wrong:  1.63e-7

Data Source:  BioPlex

XPO7

Tbio

Novelty:  0.05412704

p_int:  0.987786775

p_ni:  0.012213225

Data Source:  BioPlex

Nearest Tclin Targets (9)

Explore Nearest Tclin Targets

Upstream (7)

Downstream (2)

1 – 5 of 7

EGFR

Tclin

Family:  Kinase

KEGG Distance:  5

Common Pathways:  7

1: Gastric cancer

2: Cushing syndrome

3: Breast cancer

4: Hepatocellular carcinoma

more:  3 more common pathways

BRAF

Tclin

Family:  Kinase

KEGG Distance:  5

Common Pathways:  7

1: Gastric cancer

2: mTOR signaling pathway

3: Cushing syndrome

4: Breast cancer

more:  3 more common pathways

MAP2K2

Tclin

Family:  Kinase

KEGG Distance:  5

Common Pathways:  10

1: Gastric cancer

2: mTOR signaling pathway

3: Cushing syndrome

4: Breast cancer

more:  6 more common pathways

RAF1

Tclin

Family:  Kinase

KEGG Distance:  5

Common Pathways:  9

1: Gastric cancer

2: mTOR signaling pathway

3: Breast cancer

4: Signaling pathways regulating pluripotency of stem cells

more:  5 more common pathways

MAP2K1

Tclin

Family:  Kinase

KEGG Distance:  5

Common Pathways:  10

1: Gastric cancer

2: mTOR signaling pathway

3: Cushing syndrome

4: Breast cancer

more:  6 more common pathways

Pathways (54)

Reactome (4)

KEGG (13)

PathwayCommons (30)

WikiPathways (7)

Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080
Reactome	GPCR ligand binding	460 targets	R-HSA-500792
Reactome	Signal Transduction	2704 targets	R-HSA-162582
Reactome	Signaling by GPCR	1212 targets	R-HSA-372790

Name	Explore in Pharos	Explore in Source
Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080
GPCR ligand binding	460 targets	R-HSA-500792
Signal Transduction	2704 targets	R-HSA-162582
Signaling by GPCR	1212 targets	R-HSA-372790

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (17)

Functions (3)

Components (5)

Processes (9)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
Wnt-activated receptor activity	Inferred from Direct Assay (IDA)	WormBase
Wnt-protein binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
G protein-coupled receptor activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Alopecia	Orphanet_79364	1	2	2		54.3
balding measurement	EFO_0007825	2	1	2		40.6
mathematical ability	EFO_0004875	3	1	3		13.6
androgenetic alopecia	EFO_0004191	2	1	1	1.2	12.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Alopecia	Orphanet_79364	2		54.3
balding measurement	EFO_0007825	2		40.6
mathematical ability	EFO_0004875	3		13.6
androgenetic alopecia	EFO_0004191	1	1.2	12.2

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Cell membrane
Complete proteome
Developmental protein
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Receptor
Reference proteome
Signal

GWAS Trait Find Similar Targets

No Header	No Header
Alopecia
androgenetic alopecia
balding measurement
mathematical ability

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	frizzled class receptor 10	VGNC:5395	467160
Macaque	frizzled class receptor 10		717812
Mouse	frizzled class receptor 10	MGI:2136761	93897
Dog	frizzled class receptor 10	VGNC:41029	486232
Horse	frizzled class receptor 10	VGNC:18170	100062909

Species	Name	OMA	EggNOG	Inparanoid
Chimp	frizzled class receptor 10
Macaque	frizzled class receptor 10
Mouse	frizzled class receptor 10
Dog	frizzled class receptor 10
Horse	frizzled class receptor 10

Publication Statistics

PubMed Score 42.69

PubMed score by year

Reset Zoom

PubTator Score 20.00

PubTator score by year

Reset Zoom

Patents

Patents by year

Reset Zoom

Related Publications

Text Mined References (20)

GeneRif Annotations (5)

Items per page:

10

0 of 0

PMID	Year	Title