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Tbio
TPX2
Targeting protein for Xklp2

Protein Summary
Description
Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation (PubMed:26165940).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300403
  • ENSP00000300403
  • ENSG00000088325
  • ENST00000340513
  • ENSP00000341145

Symbol
  • C20orf1
  • C20orf2
  • DIL2
  • HCA519
  • DIL2
  • p100
  • DIL-2
  • HCTP4
  • FLS353
  • HCA519
  • REPP86
  • C20orf1
  • C20orf2
  • GD:C20orf1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.95
molecular function
0.9
transcription factor binding site profile
0.83
histone modification site profile
0.81
transcription factor perturbation
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 262.22   (req: < 5)
Gene RIFs: 66   (req: <= 3)
Antibodies: 584   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 262.22   (req: >= 5)
Gene RIFs: 66   (req: > 3)
Antibodies: 584   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosaic loss of chromosome Y measurement
1
1
1
75.1
mean reticulocyte volume
1
1
1
53.1
reticulocyte measurement
1
1
1
26.3
monocyte percentage of leukocytes
1
1
1
24.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosaic loss of chromosome Y measurement
1
75.1
mean reticulocyte volume
1
53.1
reticulocyte measurement
1
26.3
monocyte percentage of leukocytes
1
24.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TPX2, microtubule nucleation factor
VGNC:10288
458157
Macaque
TPX2, microtubule nucleation factor
712961
Mouse
MGI:1919369
72119
Rat
RGD:1311894
311546
Dog
TPX2, microtubule nucleation factor
VGNC:47757
477186
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TPX2, microtubule nucleation factor
Macaque
TPX2, microtubule nucleation factor
Mouse
Rat
Dog
TPX2, microtubule nucleation factor
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9ULW0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (14)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
G2/M Transition
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Cell Cycle
Cell Cycle, Mitotic
G2/M Transition
Gene expression (Transcription)
Gene Ontology Terms (24)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (327)
1 – 10 of 327
RARRES1
Tbio
Family: Enzyme
Novelty: 0.04701793
p_int: 0.999999959
p_ni: 4.1e-8
Data Source: BioPlex
AURKA
Tchem
Family: Kinase
Novelty: 0.0010868
p_int: 0.999994627
p_ni: 0.000005373
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
MAPK14
Tchem
Family: Kinase
Novelty: 0.00045138
p_int: 0.999860655
p_ni: 0.000139345
Score: 0.158
Data Source: BioPlex,STRINGDB
RNF111
Tbio
Family: Enzyme
Novelty: 0.03059486
p_int: 0.999364525
p_ni: 0.000635464
p_wrong: 1.2e-8
Score: 0.27
Data Source: BioPlex,STRINGDB
GSTM3
Tbio
Family: Enzyme
Novelty: 0.0078192
p_int: 0.98469571
p_ni: 0.01530429
Score: 0.228
Data Source: BioPlex,STRINGDB
CDK1
Tchem
Family: Kinase
Novelty: 0.00040776
Score: 0.997
Data Source: STRINGDB
HMMR
Tbio
Novelty: 0.0039196
Score: 0.997
Data Source: Reactome,STRINGDB
TOP2A
Tclin
Family: Enzyme
Novelty: 0.00122788
Score: 0.997
Data Source: STRINGDB
KIF15
Tbio
Novelty: 0.01328603
Score: 0.996
Data Source: STRINGDB
PLK1
Tchem
Family: Kinase
Novelty: 0.00062799
Score: 0.995
Data Source: STRINGDB
Publication Statistics
PubMed Score  262.22

PubMed score by year
PubTator Score  127.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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