Tbio TPX2 Targeting protein for Xklp2

Protein Summary

Description

Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation (PubMed:26165940).

Uniprot Accession IDs

• Q9ULW0
• Q96RR5
• Q9H1R4
• Q9NRA3
• Q9UFN9
• Q9UL00
• Q9Y2M1

Gene Name

• TPX2

Ensembl ID

• ENST00000300403
• ENSP00000300403
• ENSG00000088325
• ENST00000340513
• ENSP00000341145

Symbol

• C20orf1
• C20orf2
• DIL2
• HCA519
• DIL2
• p100
• DIL-2
• HCTP4
• FLS353
• HCA519
• REPP86
• C20orf1
• C20orf2
• GD:C20orf1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.95
molecular function	0.9
transcription factor binding site profile	0.83
histone modification site profile	0.81
transcription factor perturbation	0.8

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Non-motor Microtubule Binding Protein / Targeting Protein For Xklp2

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Non-motor Microtubule Binding Protein / Targeting Protein For Xklp2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 295.11   (req: < 5)

Gene RIFs: 111   (req: <= 3)

Antibodies: 584   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 295.11   (req: >= 5)

Gene RIFs: 111   (req: > 3)

Antibodies: 584   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0