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Tbio
CBLC
E3 ubiquitin-protein ligase CBL-C

Protein Classes
Protein Summary
Description
Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival. This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270279
  • ENSP00000270279
  • ENSG00000142273
  • ENST00000341505
  • ENSP00000340250
  • ENST00000647358
  • ENSP00000494162

Symbol
  • CBL3
  • RNF57
  • CBL-3
  • RNF57
  • CBL-SL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.86
hub protein
0.82
cell type or tissue
0.71
biological process
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.63   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 344   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.63   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 344   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
2
2
97.8
low density lipoprotein cholesterol measurement
2
1
2
8
94.5
total cholesterol measurement
1
1
2
89.8
2
1
0
5.9
82.6
family history of Alzheimer’s disease
1
1
0
10.3
79.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
2
97.8
low density lipoprotein cholesterol measurement
2
8
94.5
total cholesterol measurement
2
89.8
0
5.9
82.6
family history of Alzheimer’s disease
0
10.3
79.6
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (16)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (68)
1 – 10 of 68
ABI2
Tbio
Novelty: 0.02324355
p_int: 0.999773001
p_ni: 0.000226999
Score: 0.727
Data Source: BioPlex,STRINGDB
WASF1
Tbio
Novelty: 0.00977488
p_int: 0.999743656
p_ni: 0.000256343
Score: 0.641
Data Source: BioPlex,STRINGDB
BRK1
Tbio
Novelty: 0.02289534
p_int: 0.99907558
p_ni: 0.000689324
p_wrong: 0.000235097
Score: 0.552
Data Source: BioPlex,STRINGDB
NCKAP1
Tbio
Novelty: 0.03486454
p_int: 0.997365308
p_ni: 0.002634692
Score: 0.305
Data Source: BioPlex,STRINGDB
WASF2
Tbio
Novelty: 0.00968798
p_int: 0.991318159
p_ni: 0.008356805
p_wrong: 0.000325036
Score: 0.535
Data Source: BioPlex,STRINGDB
LPP
Tbio
Novelty: 0.00624048
p_int: 0.98210144
p_ni: 0.017897114
p_wrong: 0.000001446
Score: 0.243
Data Source: BioPlex,STRINGDB
ZNHIT2
Tbio
Novelty: 0.13370912
p_int: 0.977497271
p_ni: 0.022502729
Score: 0.183
Data Source: BioPlex,STRINGDB
CYFIP2
Tbio
Novelty: 0.01910939
p_int: 0.969129021
p_ni: 0.030870979
Score: 0.544
Data Source: BioPlex,STRINGDB
GAK
Tchem
Family: Kinase
Novelty: 0.00731928
p_int: 0.962475725
p_ni: 0.03752339
p_wrong: 8.84e-7
Score: 0.177
Data Source: BioPlex,STRINGDB
CYFIP1
Tbio
Novelty: 0.01758346
p_int: 0.896568633
p_ni: 0.103431367
Score: 0.641
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  3.63

PubMed score by year
PubTator Score  121.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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