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Tbio
CORO1C
Coronin-1C

Protein Summary
Description
Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PubMed:25074804, PubMed:25925950). Increases the presence of activated RAC1 at the leading edge of migrating cells (PubMed:25074804, PubMed:25925950). Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (By similarity). Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). Required for normal cell proliferation, cell migration, and normal formation of lamellipodia (By similarity). Required for normal distribution of mitoc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261401
  • ENSP00000261401
  • ENSG00000110880
  • ENST00000420959
  • ENSP00000394496
  • ENST00000541050
  • ENSP00000438341
  • ENST00000549772
  • ENSP00000447534

Symbol
  • CRN2
  • CRNN4
  • HCRNN4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
protein domain
0.97
transcription factor binding site profile
0.92
interacting protein
0.75
disease perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.58   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 265   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.58   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 265   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
1
1
1
45.6
mean platelet volume
1
1
1
30.7
reticulocyte measurement
1
1
1
18.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
1
45.6
mean platelet volume
1
30.7
reticulocyte measurement
1
18.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coronin 1C
VGNC:8381
743796
Macaque
coronin 1C
707498
Mouse
MGI:1345964
23790
Rat
RGD:1564490
501841
Dog
coronin 1C
VGNC:39528
486318
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coronin 1C
Macaque
coronin 1C
Mouse
Rat
Dog
coronin 1C
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9ULV4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (30)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (86)
1 – 10 of 86
CORO6
Tdark
Novelty: 0.37416507
p_int: 0.999999721
p_ni: 2.79e-7
Score: 0.824
Data Source: BioPlex,STRINGDB
CORO1B
Tbio
Novelty: 0.05912813
p_int: 0.999940539
p_ni: 0.000059461
Score: 0.993
Data Source: BioPlex,STRINGDB
CORO1A
Tbio
Novelty: 0.00898925
p_int: 0.999916332
p_ni: 0.000083668
Score: 0.823
Data Source: BioPlex,STRINGDB
GTPBP1
Tbio
Novelty: 0.00160825
p_int: 0.999899464
p_ni: 0.000100536
Score: 0.282
Data Source: BioPlex,STRINGDB
ACTR2
Tbio
Novelty: 0.00731489
Score: 0.846
Data Source: STRINGDB
ACTR3
Tbio
Novelty: 0.02112745
Score: 0.789
Data Source: STRINGDB
FLOT2
Tbio
Novelty: 0.00727325
Score: 0.786
Data Source: STRINGDB
RCC2
Tbio
Novelty: 0.01806322
Score: 0.762
Data Source: STRINGDB
CDH1
Tbio
Novelty: 0.00010629
Score: 0.746
Data Source: STRINGDB
FLOT1
Tbio
Novelty: 0.00504569
Score: 0.742
Data Source: STRINGDB
Publication Statistics
PubMed Score  54.58

PubMed score by year
PubTator Score  22.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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