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Tchem
FZD4
Frizzled-4

Protein Summary
Description
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000531380
  • ENSP00000434034
  • ENSG00000174804

Symbol
  • Fz4
  • EVR1
  • FEVR
  • Fz-4
  • FzE4
  • GPCR
  • hFz4
  • CD344
  • FZD4S
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.96
histone modification site profile
0.79
transcription factor perturbation
0.74
molecular function
0.73
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.05   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 465   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.05   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 465   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (2)
1 – 2 of 2
FzM1
Rendered image for FzM1
FzM1.8
Rendered image for FzM1.8
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
2
4
93.7
blood urea nitrogen measurement
1
1
1
56.6
cup-to-disc ratio measurement
2
2
2
54.3
serum urea measurement
1
1
1
36.9
bone density
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
93.7
blood urea nitrogen measurement
1
56.6
cup-to-disc ratio measurement
2
54.3
serum urea measurement
1
36.9
bone density
1
15.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
frizzled class receptor 4
VGNC:11783
466732
Macaque
frizzled class receptor 4
704754
Mouse
MGI:108520
14366
Rat
RGD:71017
64558
Dog
frizzled class receptor 4
VGNC:41032
485149
Species
Name
OMA
EggNOG
Inparanoid
Chimp
frizzled class receptor 4
Macaque
frizzled class receptor 4
Mouse
Rat
Dog
frizzled class receptor 4
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9ULV1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (70)
Asymmetric localization of PCP proteins (R-HSA-4608870)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asymmetric localization of PCP proteins
Reactome
Beta-catenin independent WNT signaling
Reactome
Ca2+ pathway
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Class B/2 (Secretin family receptors)
Name
Explore in Pharos
Explore in Source
Asymmetric localization of PCP proteins
Beta-catenin independent WNT signaling
Ca2+ pathway
Cargo recognition for clathrin-mediated endocytosis
Class B/2 (Secretin family receptors)
Gene Ontology Terms (43)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Protein-Protein Interactions (249)
1 – 10 of 249
TSPAN15
Tbio
Novelty:  0.16947672
p_int:  0.9990887
p_ni:  0.000911039
p_wrong:  2.61e-7
Data Source:  BioPlex
CD47
Tchem
Novelty:  0.00129086
p_int:  0.94978833
p_ni:  0.047096797
p_wrong:  0.003114873
Data Source:  BioPlex
MPZL1
Tbio
Novelty:  0.03292508
p_int:  0.88257275
p_ni:  0.115654736
p_wrong:  0.001772514
Data Source:  BioPlex
CERS6
Tbio
Family:  TF
Novelty:  0.01956925
p_int:  0.83434176
p_ni:  0.161825612
p_wrong:  0.003832628
Data Source:  BioPlex
YIPF3
Tbio
Novelty:  0.12021667
p_int:  0.777086619
p_ni:  0.222912919
p_wrong:  4.62e-7
Data Source:  BioPlex
NDP
Tbio
Novelty:  0.01020963
Score:  0.997
Data Source:  STRINGDB
WNT5A
Tbio
Novelty:  0.00125563
Score:  0.988
Data Source:  Reactome,STRINGDB
LRP5
Tbio
Novelty:  0.00089807
Score:  0.988
Data Source:  STRINGDB
DVL2
Tbio
Novelty:  0.00833084
Score:  0.986
Data Source:  Reactome,STRINGDB
WNT2
Tbio
Novelty:  0.00313614
Score:  0.986
Data Source:  STRINGDB
Publication Statistics
PubMed Score  178.05

PubMed score by year
PubTator Score  93.95

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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