Protein Summary
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be ...more
- ENST00000531380
- ENSP00000434034
- ENSG00000174804
- Fz4
- EVR1
- FEVR
- Fz-4
- FzE4
- GPCR
- hFz4
- CD344
- FZD4S
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 0.96 | ||
histone modification site profile | 0.79 | ||
transcription factor perturbation | 0.74 | ||
molecular function | 0.73 | ||
protein domain | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 178.05 (req: < 5)
Gene RIFs: 55 (req: <= 3)
Antibodies: 465 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 178.05 (req: >= 5)
Gene RIFs: 55 (req: > 3)
Antibodies: 465 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 35
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (2)
Protein-Protein Interactions (249)
TSPAN15
Novelty: 0.16947672
p_int: 0.9990887
p_ni: 0.000911039
p_wrong: 2.61e-7
Data Source: BioPlex
CD47
Novelty: 0.00129086
p_int: 0.94978833
p_ni: 0.047096797
p_wrong: 0.003114873
Data Source: BioPlex
MPZL1
Novelty: 0.03292508
p_int: 0.88257275
p_ni: 0.115654736
p_wrong: 0.001772514
Data Source: BioPlex
CERS6
Family: TF
Novelty: 0.01956925
p_int: 0.83434176
p_ni: 0.161825612
p_wrong: 0.003832628
Data Source: BioPlex
YIPF3
Novelty: 0.12021667
p_int: 0.777086619
p_ni: 0.222912919
p_wrong: 4.62e-7
Data Source: BioPlex
Nearest Tclin Targets (9)
Upstream (7)
Downstream (2)
1 – 5 of 7
Pathways (70)
Reactome (20)
KEGG (13)
PathwayCommons (30)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Asymmetric localization of PCP proteins | ||||
Reactome | Beta-catenin independent WNT signaling | ||||
Reactome | Ca2+ pathway | ||||
Reactome | Cargo recognition for clathrin-mediated endocytosis | ||||
Reactome | Class B/2 (Secretin family receptors) | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Asymmetric localization of PCP proteins | ||||
Beta-catenin independent WNT signaling | ||||
Ca2+ pathway | ||||
Cargo recognition for clathrin-mediated endocytosis | ||||
Class B/2 (Secretin family receptors) | ||||
Viral Interactions (0)
Gene Ontology Terms (43)
Functions (11)
Components (8)
Processes (24)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | ARUK-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | ARUK-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | ARUK-UCL | |||
Disease Associations (null)
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 3 | 2 | 4 | 93.7 | |||||
blood urea nitrogen measurement | 1 | 1 | 1 | 56.6 | |||||
cup-to-disc ratio measurement | 2 | 2 | 2 | 54.3 | |||||
serum urea measurement | 1 | 1 | 1 | 36.9 | |||||
bone density | 1 | 1 | 1 | 15.8 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
heel bone mineral density | 4 | 93.7 | |||||
blood urea nitrogen measurement | 1 | 56.6 | |||||
cup-to-disc ratio measurement | 2 | 54.3 | |||||
serum urea measurement | 1 | 36.9 | |||||
bone density | 1 | 15.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | frizzled class receptor 4 | VGNC:11783 | 466732 | |||||
Macaque | frizzled class receptor 4 | 704754 | ||||||
Mouse | MGI:108520 | 14366 | ||||||
Rat | RGD:71017 | 64558 | ||||||
Dog | frizzled class receptor 4 | VGNC:41032 | 485149 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | frizzled class receptor 4 | |||||
Macaque | frizzled class receptor 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | frizzled class receptor 4 | |||||
Publication Statistics
PubMed Score 178.05
PubMed score by year
PubTator Score 93.95
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (80)
GeneRif Annotations (55)
Items per page:
0 of 0
PMID | Year | Title |
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