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Tbio
CADPS
Calcium-dependent secretion activator 1

Protein Summary
Description
Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity). This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosph ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000283269
  • ENSP00000283269
  • ENSG00000163618
  • ENST00000357948
  • ENSP00000350632
  • ENST00000383710
  • ENSP00000373215
  • ENST00000490353
  • ENSP00000418736

Symbol
  • CAPS
  • CAPS1
  • KIAA1121
  • CAPS
  • CAPS1
  • CADPS1
  • UNC-31
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
cell type or tissue
0.8
transcription factor perturbation
0.8
protein domain
0.73
PubMedID
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.88   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.88   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
2
3
86.9
self reported educational attainment
3
3
2
12.8
84.7
mathematical ability
2
2
2
84.2
fasting blood glucose measurement
1
1
0
7
69.7
waist-hip ratio
1
1
1
67
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
86.9
self reported educational attainment
2
12.8
84.7
mathematical ability
2
84.2
fasting blood glucose measurement
0
7
69.7
waist-hip ratio
1
67
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium dependent secretion activator
VGNC:7962
460485
Mouse
MGI:1350922
27062
Rat
RGD:708573
26989
Dog
calcium dependent secretion activator
VGNC:38658
484705
Horse
calcium dependent secretion activator
VGNC:16002
100056410
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium dependent secretion activator
Mouse
Rat
Dog
calcium dependent secretion activator
Horse
calcium dependent secretion activator
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9ULU8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (11)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (97)
1 – 10 of 97
PAN3
Tdark
Family: Kinase
Novelty: 3.36673347
p_int: 0.999999992
p_ni: 8e-9
p_wrong: 1e-9
Data Source: BioPlex
PAN2
Tbio
Family: Enzyme
Novelty: 0.1195117
p_int: 0.999999895
p_ni: 1e-7
p_wrong: 4e-9
Data Source: BioPlex
TC2N
Tbio
Novelty: 0.16223714
p_int: 0.999999434
p_ni: 4.3e-8
p_wrong: 5.23e-7
Data Source: BioPlex
MINDY2
Tbio
Novelty: 0.46783751
p_int: 0.999999051
p_ni: 9.15e-7
p_wrong: 3.5e-8
Data Source: BioPlex
FYCO1
Tbio
Novelty: 0.06181219
p_int: 0.999998685
p_ni: 0.000001315
Data Source: BioPlex
MARF1
Tdark
Novelty: 0.07787954
p_int: 0.999996393
p_ni: 4.4e-8
p_wrong: 0.000003562
Data Source: BioPlex
CLIP1
Tbio
Novelty: 0.00399891
p_int: 0.999984884
p_ni: 0.000015076
p_wrong: 4e-8
Score: 0.695
Data Source: BioPlex,STRINGDB
ACOT7
Tbio
Family: Enzyme
Novelty: 0.01093954
p_int: 0.999794107
p_ni: 0.000205893
Data Source: BioPlex
GORAB
Tbio
Novelty: 0.06288992
p_int: 0.998731627
p_ni: 0.000014006
p_wrong: 0.001254367
Data Source: BioPlex
MTMR4
Tbio
Family: Enzyme
Novelty: 0.09166984
p_int: 0.973591784
p_ni: 0.026377469
p_wrong: 0.000030747
Score: 0.21
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  62.88

PubMed score by year
PubTator Score  17.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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