Tbio HECTD1 E3 ubiquitin-protein ligase HECTD1

Protein Summary

Description

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion. Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure.

Uniprot Accession IDs

• Q9ULT8
• D3DS86
• Q6P445
• Q86VJ1
• Q96F34
• Q9UFZ7

Gene Name

• HECTD1

Ensembl ID

• ENST00000399332
• ENSP00000382269
• ENSG00000092148
• ENST00000553700
• ENSP00000450697

Symbol

• KIAA1131
• EULIR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
small molecule perturbation	0.9
histone modification site profile	0.86
transcription factor perturbation	0.84
transcription factor binding site profile	0.77

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.39   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 97   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.39   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0