ZNRF3
E3 ubiquitin-protein ligase ZNRF3
Protein Summary
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone (PubMed:22575959). Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (By similarity).
- ENST00000402174
- ENSP00000384456
- ENSG00000183579
- ENST00000406323
- ENSP00000384553
- ENST00000544604
- ENSP00000443824
- KIAA1133
- RNF203
- RNF203
- BK747E2.3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.76 | ||
histone modification site profile | 0.74 | ||
transcription factor | 0.71 | ||
tissue sample | 0.63 | ||
cell line | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 35.95 (req: < 5)
Gene RIFs: 19 (req: <= 3)
Antibodies: 80 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 35.95 (req: >= 5)
Gene RIFs: 19 (req: > 3)
Antibodies: 80 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (43)
UBE2W
Novelty: 0.07255713
p_int: 0.998487338
p_ni: 0.000012133
p_wrong: 0.001500529
Score: 0.22
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (6)
Reactome (4)
KEGG (1)
UniProt (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Regulation of FZD by ubiquitination | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by WNT | ||||
Reactome | TCF dependent signaling in response to WNT | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Regulation of FZD by ubiquitination | ||||
Signal Transduction | ||||
Signaling by WNT | ||||
TCF dependent signaling in response to WNT | ||||
Viral Interactions (0)
Gene Ontology Terms (15)
Functions (4)
Components (2)
Processes (9)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (49)
Items per page:
1 – 5 of 49
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 3 | 14 | 19 | 99.5 | |||||
cup-to-disc ratio measurement | 4 | 5 | 6 | 97.7 | |||||
BMI-adjusted waist-hip ratio | 10 | 5 | 20 | 96.7 | |||||
waist-hip ratio | 7 | 6 | 11 | 95.2 | |||||
red blood cell distribution width | 4 | 3 | 4 | 93.1 | |||||
Items per page:
1 – 5 of 49
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 19 | 99.5 | |||||
cup-to-disc ratio measurement | 6 | 97.7 | |||||
BMI-adjusted waist-hip ratio | 20 | 96.7 | |||||
waist-hip ratio | 11 | 95.2 | |||||
red blood cell distribution width | 4 | 93.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | zinc and ring finger 3 | VGNC:7810 | 458737 | |||||
Macaque | zinc and ring finger 3 | 714156 | ||||||
Mouse | MGI:3039616 | 407821 | ||||||
Dog | zinc and ring finger 3 | VGNC:48840 | 486339 | |||||
Horse | zinc and ring finger 3 | VGNC:25402 | 100059173 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | zinc and ring finger 3 | |||||
Macaque | zinc and ring finger 3 | |||||
Mouse | ||||||
Dog | zinc and ring finger 3 | |||||
Horse | zinc and ring finger 3 | |||||
Publication Statistics
PubMed Score 35.95
PubMed score by year
PubTator Score 21.11
PubTator score by year
Related Publications
Text Mined References (31)
GeneRif Annotations (19)
Items per page:
0 of 0
PMID | Year | Title |
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