Tbio ZNRF3 E3 ubiquitin-protein ligase ZNRF3

Protein Summary

Description

E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone (PubMed:22575959). Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (By similarity).

Uniprot Accession IDs

• Q9ULT6
• B3KU18
• Q6ICH1
• Q6NTF8
• Q8WU18

Gene Name

• ZNRF3

Ensembl ID

• ENST00000402174
• ENSP00000384456
• ENSG00000183579
• ENST00000406323
• ENSP00000384553
• ENST00000544604
• ENSP00000443824

Symbol

• KIAA1133
• RNF203
• RNF203
• BK747E2.3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.76
histone modification site profile	0.74
transcription factor	0.71
tissue sample	0.63
cell line	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.21   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 80   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.21   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0