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Tbio
TTC7A
Tetratricopeptide repeat protein 7A

Protein Summary
Description
Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:23229899, PubMed:24417819). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, plays a central role in bridging PI4KA to EFR3B and FAM126A, via direct interactions (By similarity). This gene encodes a protein containing tetratricopeptide repeats. Mutations in this gene disrupt intestinal development and can cause early onset inflammatory bowel disease and intestinal atresia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319190
  • ENSP00000316699
  • ENSG00000068724
  • ENST00000394850
  • ENSP00000378320

Symbol
  • KIAA1140
  • TTC7
  • TTC7
  • GIDID
  • MINAT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.88
transcription factor perturbation
0.74
protein domain
0.73
histone modification site profile
0.71
transcription factor
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.85   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.85   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
1
1
42.3
mean reticulocyte volume
1
1
1
33.1
visceral adipose tissue measurement
1
1
1
31.4
platelet crit
1
1
1
8.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
42.3
mean reticulocyte volume
1
33.1
visceral adipose tissue measurement
1
31.4
platelet crit
1
8.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tetratricopeptide repeat domain 7A
VGNC:10801
459211
Macaque
tetratricopeptide repeat domain 7A
715122
Mouse
MGI:1920999
225049
Rat
RGD:1306211
362696
Dog
tetratricopeptide repeat domain 7A
VGNC:47961
474583
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tetratricopeptide repeat domain 7A
Macaque
tetratricopeptide repeat domain 7A
Mouse
Rat
Dog
tetratricopeptide repeat domain 7A
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9ULT0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (38)
1 – 10 of 38
CAMKV
Tbio
Family:  Kinase
Novelty:  0.17794181
p_int:  0.836874862
p_ni:  0.163125138
Score:  0.237
Data Source:  BioPlex,STRINGDB
EFR3B
Tbio
Novelty:  0.61495463
Score:  0.854
Data Source:  STRINGDB
PI4KA
Tchem
Family:  Kinase
Novelty:  0.01701469
Score:  0.75
Data Source:  STRINGDB
EFR3A
Tbio
Novelty:  0.17687362
Score:  0.704
Data Source:  STRINGDB
CLEC16A
Tbio
Novelty:  0.0212098
Score:  0.657
Data Source:  STRINGDB
EOGT
Tbio
Family:  Enzyme
Novelty:  0.08290891
Score:  0.648
Data Source:  STRINGDB
MCFD2
Tbio
Novelty:  0.0402944
Score:  0.62
Data Source:  STRINGDB
NUBP1
Tbio
Novelty:  0.03429412
Score:  0.61
Data Source:  STRINGDB
TMF1
Tbio
Novelty:  0.02543575
Score:  0.603
Data Source:  STRINGDB
CRIPT
Tbio
Novelty:  0.03889499
Score:  0.592
Data Source:  STRINGDB
Publication Statistics
PubMed Score  41.85

PubMed score by year
PubTator Score  26.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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