You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
TPCN1
Two pore calcium channel protein 1

Protein Summary
Description
Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal and endosomal membrane. Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to S6. TPCN1 is similar to these channels, but it has only 2 domains containing S1 to S6 (Ishibashi et al., 2000 [PubMed 10753632]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335509
  • ENSP00000335300
  • ENSG00000186815
  • ENST00000541517
  • ENSP00000438125
  • ENST00000550785
  • ENSP00000448083

Symbol
  • KIAA1169
  • TPC1
  • TPC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
molecular function
0.94
transcription factor binding site profile
0.83
virus perturbation
0.79
transcription factor
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 244.73   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 51   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 244.73   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
verapamil
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
6.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
6.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
two pore segment channel 1
VGNC:13480
452272
Macaque
two pore segment channel 1
712964
Mouse
MGI:2182472
252972
Rat
RGD:708494
246215
Dog
two pore segment channel 1
VGNC:47732
477492
Species
Name
OMA
EggNOG
Inparanoid
Chimp
two pore segment channel 1
Macaque
two pore segment channel 1
Mouse
Rat
Dog
two pore segment channel 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9ULQ1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Protein-Protein Interactions (45)
1 – 10 of 45
TNFRSF1A
Tchem
Novelty: 0.00037847
p_int: 0.999939942
p_ni: 0.000060058
Data Source: BioPlex
LPAR1
Tchem
Family: GPCR
Novelty: 0.00318056
p_int: 0.999915366
p_ni: 0.000084633
p_wrong: 1e-9
Score: 0.152
Data Source: BioPlex,STRINGDB
TMEM171
Tdark
Novelty: 2.00247773
p_int: 0.999610785
p_ni: 0.000380734
p_wrong: 0.000008481
Score: 0.158
Data Source: BioPlex,STRINGDB
PMEL
Tbio
Novelty: 0.00116525
p_int: 0.998721161
p_ni: 0.001278819
p_wrong: 2.1e-8
Data Source: BioPlex
TMEM9
Tbio
Novelty: 0.06916197
p_int: 0.997872681
p_ni: 0.000939225
p_wrong: 0.001188094
Data Source: BioPlex
TNFRSF19
Tbio
Novelty: 0.01295599
p_int: 0.974736106
p_ni: 0.025263019
p_wrong: 8.75e-7
Score: 0.183
Data Source: BioPlex,STRINGDB
LRRC52
Tbio
Family: IC
Novelty: 0.15407898
p_int: 0.935659041
p_ni: 0.011959238
p_wrong: 0.05238172
Data Source: BioPlex
RET
Tclin
Family: Kinase
Novelty: 0.00028324
Score: 0.723
Data Source: STRINGDB
MCOLN1
Tchem
Family: IC
Novelty: 0.00442768
Score: 0.683
Data Source: STRINGDB
NOA1
Tbio
Novelty: 0.01478325
Score: 0.661
Data Source: STRINGDB
Publication Statistics
PubMed Score  244.73

PubMed score by year
PubTator Score  153.23

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer