TPCN1
Two pore calcium channel protein 1
Protein Summary
Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal and endosomal membrane. Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to S6. TPCN1 is similar to these channels, but it has only 2 domains containing S1 to S6 (Ishibashi et al., 2000 [PubMed 10753632]).[supplied by OMIM, Mar 2008]
- ENST00000335509
- ENSP00000335300
- ENSG00000186815
- ENST00000541517
- ENSP00000438125
- ENST00000550785
- ENSP00000448083
- KIAA1169
- TPC1
- TPC1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.96 | ||
molecular function | 0.94 | ||
transcription factor binding site profile | 0.83 | ||
virus perturbation | 0.79 | ||
transcription factor | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 323.9 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 51 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 323.9 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 51 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (2)
Protein-Protein Interactions (45)
LPAR1
Family: GPCR
Novelty: 0.00318056
p_int: 0.999915366
p_ni: 0.000084633
p_wrong: 1e-9
Score: 0.152
Data Source: BioPlex,STRINGDB
TMEM171
Novelty: 2.00247773
p_int: 0.999610785
p_ni: 0.000380734
p_wrong: 0.000008481
Score: 0.158
Data Source: BioPlex,STRINGDB
PMEL
Novelty: 0.00116525
p_int: 0.998721161
p_ni: 0.001278819
p_wrong: 2.1e-8
Data Source: BioPlex
TMEM9
Novelty: 0.06916197
p_int: 0.997872681
p_ni: 0.000939225
p_wrong: 0.001188094
Data Source: BioPlex
TNFRSF19
Novelty: 0.01295599
p_int: 0.974736106
p_ni: 0.025263019
p_wrong: 8.75e-7
Score: 0.183
Data Source: BioPlex,STRINGDB
LRRC52
Family: IC
Novelty: 0.15407898
p_int: 0.935659041
p_ni: 0.011959238
p_wrong: 0.05238172
Data Source: BioPlex
Nearest Tclin Targets
Pathways (5)
Reactome (3)
KEGG (1)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Ion channel transport | ||||
Reactome | Stimuli-sensing channels | ||||
Reactome | Transport of small molecules | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Ion channel transport | ||||
Stimuli-sensing channels | ||||
Transport of small molecules | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (3)
Components (5)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
response to fenofibrate | 1 | 1 | 1 | 36.9 | |||||
body mass index | 1 | 1 | 1 | 17.7 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
response to fenofibrate | 1 | 36.9 | |||||
body mass index | 1 | 17.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | two pore segment channel 1 | VGNC:13480 | 452272 | |||||
Macaque | two pore segment channel 1 | 712964 | ||||||
Mouse | MGI:2182472 | 252972 | ||||||
Rat | RGD:708494 | 246215 | ||||||
Dog | two pore segment channel 1 | VGNC:47732 | 477492 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | two pore segment channel 1 | |||||
Macaque | two pore segment channel 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | two pore segment channel 1 | |||||
Publication Statistics
PubMed Score 323.90
PubMed score by year
PubTator Score 153.23
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (26)
GeneRif Annotations (13)
Items per page:
0 of 0
PMID | Year | Title |
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