Tchem TPCN1 Two pore calcium channel protein 1

Protein Summary

Description

Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal and endosomal membrane. Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to S6. TPCN1 is similar to these channels, but it has only 2 domains containing S1 to S6 (Ishibashi et al., 2000 [PubMed 10753632]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q9ULQ1
• A7E258
• Q86XS9
• Q8NC20

Gene Name

• TPCN1

Ensembl ID

• ENST00000335509
• ENSP00000335300
• ENSG00000186815
• ENST00000541517
• ENSP00000438125
• ENST00000550785
• ENSP00000448083

Symbol

• KIAA1169
• TPC1
• TPC1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.96
molecular function	0.94
transcription factor binding site profile	0.83
virus perturbation	0.79
transcription factor	0.72

Protein Classes

DTO Classes

Protein / Ion Channel / Calcium Channel Alpha-1 Subunit Family / Two Pore Calcium Channel Subfamily / Two Pore Calcium Channel Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 323.9   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 51   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 323.9   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1