Tchem TPCN1 Two pore calcium channel protein 1

Protein Classes

DTO Classes

Protein / Ion Channel / Calcium Channel Alpha-1 Subunit Family / Two Pore Calcium Channel Subfamily / Two Pore Calcium Channel Protein 1

Protein Summary

Description

Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal and endosomal membrane. Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to S6. TPCN1 is similar to these channels, but it has only 2 domains containing S1 to S6 (Ishibashi et al., 2000 [PubMed 10753632]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q9ULQ1
• A7E258
• Q86XS9
• Q8NC20

Gene Name

• TPCN1

Ensembl ID

• ENST00000335509
• ENSP00000335300
• ENSG00000186815
• ENST00000541517
• ENSP00000438125
• ENST00000550785
• ENSP00000448083

Symbol

• KIAA1169
• TPC1
• TPC1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.96
molecular function	0.94
transcription factor binding site profile	0.83
virus perturbation	0.79
transcription factor	0.72

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 253.05   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 51   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 253.05   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Approved Drugs (1)

Explore Approved Drugs

1 – 1 of 1

verapamil

TPCN1Tchem IC

IC50 : 4.63999987

Active Ligands (2)

Explore Active Ligands

1 – 2 of 2

Cd²⁺

TPCN1Tchem IC

IC50 : 3.74000001

phosphatidyl (3,5) inositol bisphosphate

TPCN1Tchem IC

EC50 : 6.51999998

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body mass index	EFO_0004340	1	1	1		26.1
response to fenofibrate	GO_1901557	1	1	1		14.2

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body mass index	EFO_0004340	1		26.1
response to fenofibrate	GO_1901557	1		14.2

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Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	two pore segment channel 1	VGNC:13480	452272
Macaque	two pore segment channel 1		712964
Mouse	two pore channel 1	MGI:2182472	252972
Rat	two pore segment channel 1	RGD:708494	246215
Dog	two pore segment channel 1	VGNC:47732	477492

Species	Name	OMA	EggNOG	Inparanoid
Chimp	two pore segment channel 1
Macaque	two pore segment channel 1
Mouse	two pore channel 1
Rat	two pore segment channel 1
Dog	two pore segment channel 1

Protein Structure (0 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q9ULQ1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)

Reactome (3)

KEGG (1)

PathwayCommons (1)

Ion channel transport (R-HSA-983712)

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Find Similar Targets

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1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Ion channel transport	179 targets	R-HSA-983712
Reactome	Stimuli-sensing channels	102 targets	R-HSA-2672351
Reactome	Transport of small molecules	725 targets	R-HSA-382551

Name	Explore in Pharos	Explore in Source
Ion channel transport	179 targets	R-HSA-983712
Stimuli-sensing channels	102 targets	R-HSA-2672351
Transport of small molecules	725 targets	R-HSA-382551

Gene Ontology Terms (11)

Functions (3)

Components (5)

Processes (3)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
NAADP-sensitive calcium-release channel activity	Inferred from Direct Assay (IDA)	UniProtKB
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
voltage-gated calcium channel activity	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (45)

Explore Interacting Targets

1 – 10 of 45

• See Interactions on String-DB

TNFRSF1A

Tchem

Novelty:  0.00037847

p_int:  0.999939942

p_ni:  0.000060058

Data Source:  BioPlex

LPAR1

Tchem

Family:  GPCR

Novelty:  0.00318056

p_int:  0.999915366

p_ni:  0.000084633

p_wrong:  1e-9

Score:  0.152

Data Source:  BioPlex,STRINGDB

TMEM171

Tdark

Novelty:  2.00247773

p_int:  0.999610785

p_ni:  0.000380734

p_wrong:  0.000008481

Score:  0.158

Data Source:  BioPlex,STRINGDB

PMEL

Tbio

Novelty:  0.00116525

p_int:  0.998721161

p_ni:  0.001278819

p_wrong:  2.1e-8

Data Source:  BioPlex

TMEM9

Tbio

Novelty:  0.06916197

p_int:  0.997872681

p_ni:  0.000939225

p_wrong:  0.001188094

Data Source:  BioPlex

TNFRSF19

Tbio

Novelty:  0.01295599

p_int:  0.974736106

p_ni:  0.025263019

p_wrong:  8.75e-7

Score:  0.183

Data Source:  BioPlex,STRINGDB

LRRC52

Tbio

Family:  IC

Novelty:  0.15407898

p_int:  0.935659041

p_ni:  0.011959238

p_wrong:  0.05238172

Data Source:  BioPlex

RET

Tclin

Family:  Kinase

Novelty:  0.00028324

Score:  0.723

Data Source:  STRINGDB

MCOLN1

Tchem

Family:  IC

Novelty:  0.00442768

Score:  0.683

Data Source:  STRINGDB

NOA1

Tbio

Novelty:  0.01478325

Score:  0.661

Data Source:  STRINGDB

Publication Statistics

PubMed Score  253.05

PubMed score by year

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PubTator Score  153.23

PubTator score by year

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Patents

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Calcium
Calcium channel
Calcium transport
Coiled coil
Complete proteome
Endosome
Glycoprotein
Ion channel
Ion transport

GWAS Trait Find Similar Targets

No Header	No Header
body mass index
response to fenofibrate

MGI Phenotype Find Similar Targets

No Header	No Header
hematopoietic system phenotype