NDRG4
Protein NDRG4
Protein Summary
Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By similarity). May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner. This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that is required for cell cycle progression and survival in primary astrocytes and may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Alternative splicing results in multiple transcripts encoding different isoforms.[provided by RefSeq, Jun 2011]
- ENST00000258187
- ENSP00000258187
- ENSG00000103034
- ENST00000356752
- ENSP00000349193
- ENST00000394279
- ENSP00000377820
- ENST00000394282
- ENSP00000377823
- ENST00000563799
- ENSP00000458113
- ENST00000566192
- ENSP00000454410
- ENST00000568640
- ENSP00000456338
- ENST00000570248
- ENSP00000457659
- BDM1
- KIAA1180
- BDM1
- SMAP8
- SMAP-8
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.97 | ||
PubMedID | 0.78 | ||
biological process | 0.73 | ||
small molecule perturbation | 0.71 | ||
tissue | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 74.06 (req: < 5)
Gene RIFs: 32 (req: <= 3)
Antibodies: 263 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 74.06 (req: >= 5)
Gene RIFs: 32 (req: > 3)
Antibodies: 263 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0