Protein Summary
Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By similarity). May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner. This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that is required for cell cycle progression and survival in primary astrocytes and may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Alternative splicing results in multiple transcripts encoding different isoforms.[provided by RefSeq, Jun 2011]
- ENST00000258187
- ENSP00000258187
- ENSG00000103034
- ENST00000356752
- ENSP00000349193
- ENST00000394279
- ENSP00000377820
- ENST00000394282
- ENSP00000377823
- ENST00000563799
- ENSP00000458113
- ENST00000566192
- ENSP00000454410
- ENST00000568640
- ENSP00000456338
- ENST00000570248
- ENSP00000457659
- BDM1
- KIAA1180
- BDM1
- SMAP8
- SMAP-8
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.97 | ||
PubMedID | 0.78 | ||
biological process | 0.73 | ||
small molecule perturbation | 0.71 | ||
tissue | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 64.26 (req: < 5)
Gene RIFs: 22 (req: <= 3)
Antibodies: 263 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 64.26 (req: >= 5)
Gene RIFs: 22 (req: > 3)
Antibodies: 263 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (45)
FXYD1
Family: IC
Novelty: 0.00421639
p_int: 0.999988531
p_ni: 0.000005689
p_wrong: 0.00000578
Score: 0.266
Data Source: BioPlex,STRINGDB
NUFIP1
Novelty: 0.11726869
p_int: 0.999854
p_ni: 0.00011389
p_wrong: 0.00003211
Data Source: BioPlex
DNAAF2
Novelty: 0.01254416
p_int: 0.999342966
p_ni: 0.000578107
p_wrong: 0.000078927
Data Source: BioPlex
HAX1
Novelty: 0.00749205
p_int: 0.999342966
p_ni: 0.000578107
p_wrong: 0.000078927
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (21)
Components (6)
Processes (15)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Disease Associations ()
GWAS Traits (13)
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
electrocardiography | 2 | 3 | 95 | 95.9 | |||||
QT interval | 5 | 6 | 0 | 2.3 | 94 | ||||
sex hormone-binding globulin measurement | 4 | 1 | 4 | 67.3 | |||||
pulse pressure measurement | 1 | 1 | 1 | 59 | |||||
3 | 3 | 1 | 1.1 | 58.2 | |||||
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
electrocardiography | 95 | 95.9 | |||||
QT interval | 0 | 2.3 | 94 | ||||
sex hormone-binding globulin measurement | 4 | 67.3 | |||||
pulse pressure measurement | 1 | 59 | |||||
1 | 1.1 | 58.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | NDRG family member 4 | VGNC:5847 | 454376 | |||||
Macaque | NDRG family member 4 | 712742 | ||||||
Mouse | MGI:2384590 | 234593 | ||||||
Rat | RGD:621593 | 64457 | ||||||
Dog | NDRG family member 4 | VGNC:43681 | 611099 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | NDRG family member 4 | |||||
Macaque | NDRG family member 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | NDRG family member 4 | |||||
Publication Statistics
PubMed Score 64.26
PubMed score by year
PubTator Score 28.68
PubTator score by year
Related Publications
Text Mined References (43)
GeneRif Annotations (22)
Items per page:
0 of 0
PMID | Year | Title |
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