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Tbio
NDRG4
Protein NDRG4

Protein Summary
Description
Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By similarity). May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner. This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that is required for cell cycle progression and survival in primary astrocytes and may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Alternative splicing results in multiple transcripts encoding different isoforms.[provided by RefSeq, Jun 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258187
  • ENSP00000258187
  • ENSG00000103034
  • ENST00000356752
  • ENSP00000349193
  • ENST00000394279
  • ENSP00000377820
  • ENST00000394282
  • ENSP00000377823
  • ENST00000563799
  • ENSP00000458113
  • ENST00000566192
  • ENSP00000454410
  • ENST00000568640
  • ENSP00000456338
  • ENST00000570248
  • ENSP00000457659

Symbol
  • BDM1
  • KIAA1180
  • BDM1
  • SMAP8
  • SMAP-8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
PubMedID
0.78
biological process
0.73
small molecule perturbation
0.71
tissue
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
View Data
 GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.17   (req: < 5)
View Publications
Gene RIFs: 22   (req: <= 3)
View Gene RIFs
Antibodies: 263   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.17   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 263   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
EFO_0004696
4
1
4
90.6
electrocardiography
EFO_0004327
1
1
87
68.2
testosterone measurement
EFO_0004908
1
1
1
37
schizophrenia
EFO_0000692
1
1
0
1.1
35.4
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
EFO_0004696
4
90.6
electrocardiography
EFO_0004327
87
68.2
testosterone measurement
EFO_0004908
1
37
schizophrenia
EFO_0000692
0
1.1
35.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NDRG family member 4
VGNC:5847
454376
Macaque
NDRG family member 4
712742
Mouse
N-myc downstream regulated gene 4
MGI:2384590
234593
Rat
NDRG family member 4
RGD:621593
64457
Dog
NDRG family member 4
VGNC:43681
611099
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NDRG family member 4
Macaque
NDRG family member 4
Mouse
N-myc downstream regulated gene 4
Rat
NDRG family member 4
Dog
NDRG family member 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9ULP0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (21)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
basolateral plasma membrane
Inferred from Direct Assay (IDA)
BHF-UCL
cytoplasm
Inferred from Direct Assay (IDA)
BHF-UCL
endoplasmic reticulum membrane
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
mitochondrion
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
cell projection membrane
Inferred from Electronic Annotation (IEA)
Ensembl
cytosol
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (45)
1 – 10 of 45
FXYD1
Tbio
Family: IC
Novelty: 0.00421639
p_int: 0.999988531
p_ni: 0.000005689
p_wrong: 0.00000578
Score: 0.266
Data Source: BioPlex,STRINGDB
NUFIP1
Tbio
Novelty: 0.11726869
p_int: 0.999854
p_ni: 0.00011389
p_wrong: 0.00003211
Data Source: BioPlex
DNAAF2
Tbio
Novelty: 0.01254416
p_int: 0.999342966
p_ni: 0.000578107
p_wrong: 0.000078927
Data Source: BioPlex
HAX1
Tbio
Novelty: 0.00749205
p_int: 0.999342966
p_ni: 0.000578107
p_wrong: 0.000078927
Data Source: BioPlex
BVES
Tbio
Novelty: 0.02309912
Score: 0.834
Data Source: STRINGDB
SULT4A1
Tbio
Family: Enzyme
Novelty: 0.02455678
Score: 0.755
Data Source: STRINGDB
BMP3
Tbio
Novelty: 0.00620559
Score: 0.739
Data Source: STRINGDB
GINS3
Tbio
Novelty: 0.02892519
Score: 0.733
Data Source: STRINGDB
LZTS1
Tbio
Novelty: 0.02747372
Score: 0.676
Data Source: STRINGDB
MYCN
Tbio
Family: TF
Novelty: 0.00038165
Score: 0.651
Data Source: STRINGDB
Publication Statistics
PubMed Score  61.17

PubMed score by year
PubTator Score  28.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer