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Tbio
NDRG4
Protein NDRG4

Protein Summary
Description
Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By similarity). May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner. This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that is required for cell cycle progression and survival in primary astrocytes and may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Alternative splicing results in multiple transcripts encoding different isoforms.[provided by RefSeq, Jun 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258187
  • ENSP00000258187
  • ENSG00000103034
  • ENST00000356752
  • ENSP00000349193
  • ENST00000394279
  • ENSP00000377820
  • ENST00000394282
  • ENSP00000377823
  • ENST00000563799
  • ENSP00000458113
  • ENST00000566192
  • ENSP00000454410
  • ENST00000568640
  • ENSP00000456338
  • ENST00000570248
  • ENSP00000457659

Symbol
  • BDM1
  • KIAA1180
  • BDM1
  • SMAP8
  • SMAP-8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
PubMedID
0.78
biological process
0.73
small molecule perturbation
0.71
tissue
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.26   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 263   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.26   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 263   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
FXYD1
Tbio
Family:  IC
Novelty:  0.00421639
p_int:  0.999988531
p_ni:  0.000005689
p_wrong:  0.00000578
Score:  0.266
Data Source:  BioPlex,STRINGDB
NUFIP1
Tbio
Novelty:  0.11726869
p_int:  0.999854
p_ni:  0.00011389
p_wrong:  0.00003211
Data Source:  BioPlex
DNAAF2
Tbio
Novelty:  0.01254416
p_int:  0.999342966
p_ni:  0.000578107
p_wrong:  0.000078927
Data Source:  BioPlex
HAX1
Tbio
Novelty:  0.00749205
p_int:  0.999342966
p_ni:  0.000578107
p_wrong:  0.000078927
Data Source:  BioPlex
BVES
Tbio
Novelty:  0.02309912
Score:  0.834
Data Source:  STRINGDB
SULT4A1
Tbio
Family:  Enzyme
Novelty:  0.02455678
Score:  0.755
Data Source:  STRINGDB
BMP3
Tbio
Novelty:  0.00620559
Score:  0.739
Data Source:  STRINGDB
GINS3
Tbio
Novelty:  0.02892519
Score:  0.733
Data Source:  STRINGDB
LZTS1
Tbio
Novelty:  0.02747372
Score:  0.676
Data Source:  STRINGDB
MYCN
Tbio
Family:  TF
Novelty:  0.00038165
Score:  0.651
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
2
3
95
95.9
QT interval
5
6
0
2.3
94
sex hormone-binding globulin measurement
4
1
4
67.3
pulse pressure measurement
1
1
1
59
3
3
1
1.1
58.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
95
95.9
QT interval
0
2.3
94
sex hormone-binding globulin measurement
4
67.3
pulse pressure measurement
1
59
1
1.1
58.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NDRG family member 4
VGNC:5847
454376
Macaque
NDRG family member 4
712742
Mouse
MGI:2384590
234593
Rat
RGD:621593
64457
Dog
NDRG family member 4
VGNC:43681
611099
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NDRG family member 4
Macaque
NDRG family member 4
Mouse
Rat
Dog
NDRG family member 4
Publication Statistics
PubMed Score 64.26
PubMed score by year
PubTator Score 28.68
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title