Tbio CNOT6 CCR4-NOT transcription complex subunit 6

Protein Summary

Description

Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence. This gene encodes the catalytic component of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substrates. The CCR4-NOT complex plays a role in many cellular processes, including miRNA-mediated repression, mRNA degradation, and transcriptional regulation. [provided by RefSeq, Dec 2014]

Uniprot Accession IDs

• Q9ULM6
• A7MD46
• D3DWR0

Gene Name

• CNOT6

Ensembl ID

• ENST00000261951
• ENSP00000261951
• ENSG00000113300
• ENST00000393356
• ENSP00000377024
• ENST00000618123
• ENSP00000481893

Symbol

• CCR4
• CCR4a
• KIAA1194
• CCR4
• Ccr4a

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.98
transcription factor perturbation	0.97
kinase perturbation	0.93
microRNA	0.9
gene perturbation	0.78

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Nuclease / Exoribonuclease / Ccr4-not Transcription Complex Subunit 6

Protein / Nucleic Acid Binding / Rna Binding Protein / Exoribonuclease / Ccr4-not Transcription Complex Subunit 6

DTO Classes

Protein / Enzyme / Nuclease / Exoribonuclease / Ccr4-not Transcription Complex Subunit 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.67   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 143   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.67   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0