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Tbio
YEATS2
YEATS domain-containing protein 2

Protein Summary
Description
Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:27103431). Summary: The protein encoded by this gene is a scaffolding subunit of the ATAC complex, which is a complex with acetyltransferase activity on histones H3 and H4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305135
  • ENSP00000306983
  • ENSG00000163872

Symbol
  • KIAA1197
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
cell line
0.69
tissue sample
0.59
protein complex
0.58
cellular component
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.74   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.74   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
white matter hyperintensity measurement
4
2
3
5.4
71.4
systolic blood pressure
1
1
1
62.6
sex hormone-binding globulin measurement
1
1
1
54.4
body height
1
1
1
42.3
C-reactive protein measurement
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
white matter hyperintensity measurement
3
5.4
71.4
systolic blood pressure
1
62.6
sex hormone-binding globulin measurement
1
54.4
body height
1
42.3
C-reactive protein measurement
1
33.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
YEATS domain containing 2
VGNC:2632
460875
Macaque
YEATS domain containing 2
707409
Mouse
MGI:2447762
208146
Rat
RGD:1566176
498112
Dog
YEATS domain containing 2
VGNC:48482
488099
Species
Name
OMA
EggNOG
Inparanoid
Chimp
YEATS domain containing 2
Macaque
YEATS domain containing 2
Mouse
Rat
Dog
YEATS domain containing 2
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9ULM3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Protein-Protein Interactions (140)
1 – 10 of 140
DR1
Tbio
Novelty:  0.00138571
p_int:  0.999999569
p_ni:  4.31e-7
Score:  0.975
Data Source:  BioPlex,STRINGDB
MBIP
Tbio
Novelty:  0.05807454
p_int:  0.999999183
p_ni:  8.17e-7
Score:  0.987
Data Source:  BioPlex,STRINGDB
TADA3
Tbio
Novelty:  0.01743814
p_int:  0.999998546
p_ni:  0.000001454
Score:  0.994
Data Source:  BioPlex,STRINGDB
WDR5
Tchem
Novelty:  0.0059945
p_int:  0.999995454
p_ni:  0.000004546
Score:  0.976
Data Source:  BioPlex,STRINGDB
IKZF5
Tbio
Family:  TF
Novelty:  0.36596327
p_int:  0.999990611
p_ni:  0.000009389
Score:  0.159
Data Source:  BioPlex,STRINGDB
SGF29
Tbio
Family:  Epigenetic
Novelty:  0.0426456
p_int:  0.999907843
p_ni:  0.000092156
Score:  0.99
Data Source:  BioPlex,STRINGDB
CARD8
Tbio
Family:  Enzyme
Novelty:  0.0146799
p_int:  0.999758
p_ni:  0.000242
Score:  0.514
Data Source:  BioPlex,STRINGDB
PSME3
Tbio
Novelty:  0.01051254
p_int:  0.999652211
p_ni:  0.000347789
Score:  0.159
Data Source:  BioPlex,STRINGDB
POLE4
Tdark
Family:  Enzyme
Novelty:  0.23346084
p_int:  0.999503708
p_ni:  0.000496292
Score:  0.887
Data Source:  BioPlex,STRINGDB
SPERT
Tbio
Novelty:  0.12255061
p_int:  0.999198276
p_ni:  0.000801724
Score:  0.542
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  6.74

PubMed score by year
PubTator Score  3.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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