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Tbio
MED23
Mediator of RNA polymerase II transcription subunit 23

Protein Summary
Description
Required for transcriptional activation subsequent to the assembly of the pre-initiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling. The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354577
  • ENSP00000346588
  • ENSG00000112282
  • ENST00000368053
  • ENSP00000357032
  • ENST00000368060
  • ENSP00000357039
  • ENST00000368068
  • ENSP00000357047
  • ENST00000539158
  • ENSP00000445072

Symbol
  • ARC130
  • CRSP3
  • DRIP130
  • KIAA1216
  • SUR2
  • SUR2
  • CRSP3
  • MRT18
  • SUR-2
  • ARC130
  • CRSP130
  • CRSP133
  • DRIP130
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.95
interacting protein
0.89
histone modification site profile
0.86
kinase perturbation
0.84
disease perturbation
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.11   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 216   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.11   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 216   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (111)
MED20
Tbio
Family:  Enzyme
Novelty:  0.02039559
p_int:  0.99999611
p_ni:  0.000003891
Score:  0.964
Data Source:  BioPlex,STRINGDB
MED18
Tbio
Family:  Enzyme
Novelty:  0.04066825
p_int:  0.999995602
p_ni:  0.000004398
Score:  0.999
Data Source:  BioPlex,STRINGDB
MED21
Tbio
Family:  Enzyme
Novelty:  0.06996616
p_int:  0.999995231
p_ni:  0.000004769
Score:  0.982
Data Source:  BioPlex,STRINGDB
MED17
Tbio
Family:  Enzyme
Novelty:  0.02984503
p_int:  0.999992626
p_ni:  0.000007374
Score:  0.985
Data Source:  BioPlex,STRINGDB
MED19
Tbio
Family:  Enzyme
Novelty:  0.03926689
p_int:  0.999992135
p_ni:  0.000007865
Score:  0.993
Data Source:  BioPlex,STRINGDB
CCNC
Tbio
Novelty:  0.00585842
p_int:  0.9999778
p_ni:  0.0000222
Score:  0.994
Data Source:  BioPlex,STRINGDB
MED1
Tbio
Family:  Enzyme
Novelty:  0.00852082
p_int:  0.999972108
p_ni:  0.000027892
Score:  0.999
Data Source:  BioPlex,STRINGDB
MED10
Tdark
Family:  Enzyme
Novelty:  0.02988632
p_int:  0.999961135
p_ni:  0.000038865
Score:  0.994
Data Source:  BioPlex,STRINGDB
MED28
Tbio
Family:  Enzyme
Novelty:  0.00362108
p_int:  0.999927502
p_ni:  0.000072498
Score:  0.999
Data Source:  BioPlex,STRINGDB
MED4
Tbio
Family:  Enzyme
Novelty:  0.01200585
p_int:  0.99980484
p_ni:  0.00019516
Score:  0.996
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Developmental Biology
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
7
6
7
6.7
94.2
vitamin D measurement
4
4
4
83.3
L-arginine measurement
1
1
0
4
71.3
4
3
3
1.1
70
creatinine measurement
2
2
2
69.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
7
6.7
94.2
vitamin D measurement
4
83.3
L-arginine measurement
0
4
71.3
3
1.1
70
creatinine measurement
2
69.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mediator complex subunit 23
VGNC:3487
472124
Macaque
mediator complex subunit 23
714629
Mouse
MGI:1917458
70208
Rat
RGD:1307671
309565
Dog
mediator complex subunit 23
VGNC:43131
474822
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mediator complex subunit 23
Macaque
mediator complex subunit 23
Mouse
Rat
Dog
mediator complex subunit 23
Publication Statistics
PubMed Score 43.11
PubMed score by year
PubTator Score 26.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title