Tbio MED23 Mediator of RNA polymerase II transcription subunit 23

Protein Summary

Description

Required for transcriptional activation subsequent to the assembly of the pre-initiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling. The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2012]

Uniprot Accession IDs

• Q9ULK4
• B9TX55
• O95403
• Q5JWT3
• Q5JWT4
• Q6P9H6
• Q9H0J2
• Q9NTT9
• Q9NTU0
• Q9Y5P7
• Q9Y667

Gene Name

• MED23

Ensembl ID

• ENST00000354577
• ENSP00000346588
• ENSG00000112282
• ENST00000368053
• ENSP00000357032
• ENST00000368060
• ENSP00000357039
• ENST00000368068
• ENSP00000357047
• ENST00000539158
• ENSP00000445072

Symbol

• ARC130
• CRSP3
• DRIP130
• KIAA1216
• SUR2
• SUR2
• CRSP3
• MRT18
• SUR-2
• ARC130
• CRSP130
• CRSP133
• DRIP130

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.95
interacting protein	0.89
histone modification site profile	0.86
kinase perturbation	0.84
disease perturbation	0.83

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.18   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 216   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.18   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 216   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0