Tbio GRID1 Glutamate receptor ionotropic, delta-1

Protein Summary

Description

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This gene encodes a subunit of glutamate receptor channels. These channels mediate most of the fast excitatory synaptic transmission in the central nervous system and play key roles in synaptic plasticity.[provided by RefSeq, Jan 2009]

Uniprot Accession IDs

• Q9ULK0
• B3KXD5
• B7Z7L0
• Q8IXT3
• GluD1

Gene Name

• GRID1

Ensembl ID

• ENST00000327946
• ENSP00000330148
• ENSG00000182771

Symbol

• KIAA1220
• GluD1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.99
cellular component	0.91
molecular function	0.79
protein domain	0.73
phenotype	0.72

Protein Classes

DTO Classes

Protein / Ion Channel / Glutamate-gated Ion Channel (Gic) Family Of Neurotransmitter Receptors / Grid1 Subfamily / Glutamate Receptor Ionotropic, Delta-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.69   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 205   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.69   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 205   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0