You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PPP1R9A
Neurabin-1

Protein Summary
Description
Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May be involved in neurite formation. Inhibits protein phosphatase 1-alpha activity (By similarity). This gene is imprinted, and located in a cluster of imprinted genes on chromosome 7q12. This gene is transcribed in both neuronal and multiple embryonic tissues, and it is maternally expressed mainly in embryonic skeletal muscle tissues and biallelically expressed in other embryonic tissues. The protein encoded by this gene includes a PDZ domain and a sterile alpha motif (SAM). It is a regulatory subunit of protein phosphatase I, and controls actin cytoskeleton reorganization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000289495
  • ENSP00000289495
  • ENSG00000158528
  • ENST00000340694
  • ENSP00000344524
  • ENST00000424654
  • ENSP00000411342
  • ENST00000433360
  • ENSP00000405514
  • ENST00000433881
  • ENSP00000398870
  • ENST00000456331
  • ENSP00000402893

Symbol
  • KIAA1222
  • NRB1
  • NRBI
  • Neurabin-I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
trait
0.86
microRNA
0.81
transcription factor perturbation
0.8
transcription factor
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.31   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.31   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
2
3
57.1
high density lipoprotein cholesterol measurement
2
2
2
53.1
stem Cell Factor measurement
1
1
1
32.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
57.1
high density lipoprotein cholesterol measurement
2
53.1
stem Cell Factor measurement
1
32.9
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
protein phosphatase 1 regulatory subunit 9A
699491
Mouse
MGI:2442401
243725
Rat
RGD:632280
84685
Dog
protein phosphatase 1 regulatory subunit 9A
VGNC:44902
482308
Horse
protein phosphatase 1 regulatory subunit 9A
VGNC:21772
100051837
Species
Name
OMA
EggNOG
Inparanoid
Macaque
protein phosphatase 1 regulatory subunit 9A
Mouse
Rat
Dog
protein phosphatase 1 regulatory subunit 9A
Horse
protein phosphatase 1 regulatory subunit 9A
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9ULJ8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (40)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (122)
1 – 10 of 122
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
p_int:  0.999999994
p_ni:  6e-9
Score:  0.883
Data Source:  BioPlex,STRINGDB
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
p_int:  0.999999969
p_ni:  3.1e-8
Score:  0.618
Data Source:  BioPlex,STRINGDB
RASSF2
Tbio
Novelty:  0.031565
p_int:  0.99964816
p_ni:  0.00035184
Score:  0.216
Data Source:  BioPlex,STRINGDB
CASQ2
Tbio
Novelty:  0.00775794
p_int:  0.998020787
p_ni:  0.001979161
p_wrong:  5.3e-8
Data Source:  BioPlex
MYO6
Tbio
Novelty:  0.01073438
p_int:  0.996485085
p_ni:  0.003514915
Score:  0.348
Data Source:  BioPlex,STRINGDB
NFKBIA
Tchem
Novelty:  0.00022873
p_int:  0.996319935
p_ni:  0.003680065
Data Source:  BioPlex
CAPZA2
Tbio
Novelty:  0.14014918
p_int:  0.989220833
p_ni:  0.01076542
p_wrong:  0.000013748
Score:  0.202
Data Source:  BioPlex,STRINGDB
MYL6
Tbio
Novelty:  0.00594485
p_int:  0.985829132
p_ni:  0.014164697
p_wrong:  0.000006171
Score:  0.173
Data Source:  BioPlex,STRINGDB
NEXN
Tbio
Novelty:  0.00745011
p_int:  0.975973192
p_ni:  0.014748641
p_wrong:  0.009278167
Score:  0.543
Data Source:  BioPlex,STRINGDB
BCL2L12
Tbio
Novelty:  0.01773637
p_int:  0.972842043
p_ni:  0.008561537
p_wrong:  0.01859642
Score:  0.228
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  19.31

PubMed score by year
PubTator Score  8.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: