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Tbio
ZBTB21
Zinc finger and BTB domain-containing protein 21

Protein Summary
Description
Acts as a transcription repressor.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310826
  • ENSP00000308759
  • ENSG00000173276
  • ENST00000398499
  • ENSP00000381512
  • ENST00000398505
  • ENSP00000381517
  • ENST00000398511
  • ENSP00000381523

Symbol
  • KIAA1227
  • ZNF295
  • ZNF295
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.97
microRNA
0.88
protein domain
0.85
transcription factor binding site profile
0.82
histone modification site profile
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.88   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.88   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
52.4
testosterone measurement
2
1
2
48.5
platelet count
1
1
1
46.5
lymphocyte percentage of leukocytes
1
1
1
20.9
lymphocyte count
1
1
1
17.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
52.4
testosterone measurement
2
48.5
platelet count
1
46.5
lymphocyte percentage of leukocytes
1
20.9
lymphocyte count
1
17.6
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
zinc finger and BTB domain containing 21
714759
Mouse
MGI:1927240
114565
Rat
RGD:1310841
304056
Horse
zinc finger and BTB domain containing 21
VGNC:25138
100058234
Cow
zinc finger and BTB domain containing 21
VGNC:37066
510136
Species
Name
OMA
EggNOG
Inparanoid
Macaque
zinc finger and BTB domain containing 21
Mouse
Rat
Horse
zinc finger and BTB domain containing 21
Cow
zinc finger and BTB domain containing 21
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9ULJ3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (52)
1 – 10 of 52
CASQ2
Tbio
Novelty:  0.00775794
p_int:  0.999999645
p_ni:  3.55e-7
Data Source:  BioPlex
ABTB1
Tbio
Novelty:  0.08918942
p_int:  0.999996358
p_ni:  0.000003641
Score:  0.307
Data Source:  BioPlex,STRINGDB
FHL3
Tbio
Novelty:  0.11505924
p_int:  0.999907507
p_ni:  0.000092493
Score:  0.168
Data Source:  BioPlex,STRINGDB
TNNC2
Tbio
Novelty:  0.07759506
p_int:  0.999883056
p_ni:  0.000116944
Data Source:  BioPlex
CHCHD4
Tbio
Novelty:  0.01204944
p_int:  0.999699433
p_ni:  0.0003005
p_wrong:  6.6e-8
Data Source:  BioPlex
PPP2R2D
Tbio
Family:  Enzyme
Novelty:  0.0658328
p_int:  0.996254089
p_ni:  0.003745897
p_wrong:  1.4e-8
Data Source:  BioPlex
KBTBD7
Tdark
Novelty:  0.4947466
p_int:  0.992832735
p_ni:  0.00716714
p_wrong:  1.24e-7
Data Source:  BioPlex
CETN1
Tbio
Novelty:  0.01208917
p_int:  0.978497413
p_ni:  0.021477226
p_wrong:  0.000025361
Score:  0.193
Data Source:  BioPlex,STRINGDB
PRICKLE3
Tbio
Novelty:  0.26347141
p_int:  0.973553682
p_ni:  0.016057829
p_wrong:  0.010388489
Data Source:  BioPlex
POLE2
Tbio
Family:  Enzyme
Novelty:  0.03129531
p_int:  0.95738081
p_ni:  0.009318427
p_wrong:  0.033300763
Score:  0.183
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  5.88

PubMed score by year
PubTator Score  2.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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