Pharos : Target Details

Tdark

Protein Summary

Description

Acts as a suppressor of ciliogenesis, specifically, the initiation of ciliogenesis.

Uniprot Accession IDs

Gene Name

ODF2L

Ensembl ID

ENST00000294678
ENSP00000294678
ENSG00000122417
ENST00000317336
ENSP00000320165
ENST00000359242
ENSP00000359600
ENST00000370566
ENSP00000359597

Symbol

BCAP
KIAA1229

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.81

microRNA	0.68

tissue sample	0.66

cell line	0.65

transcription factor	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.82 (req: < 5)

View Publications

Gene RIFs: 0 (req: <= 3)

Antibodies: 108 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.82 (req: >= 5)

Gene RIFs: 0 (req: > 3)

Antibodies: 108 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (32)

Explore Interacting Targets

1 – 10 of 32

See Interactions on String-DB

BORCS6

Tdark

Novelty: 0.83789033

p_int: 1

Score: 0.204

Data Source: BioPlex,STRINGDB

ODF2

Tbio

Novelty: 0.03203587

p_int: 0.999999839

p_ni: 1.27e-7

p_wrong: 3.4e-8

Data Source: BioPlex

BRK1

Tbio

Novelty: 0.02289534

p_int: 0.999988481

p_ni: 0.000008154

p_wrong: 0.000003365

Data Source: BioPlex

PPP1R13B

Tbio

Novelty: 0.03903985

p_int: 0.999875979

p_ni: 0.000019641

p_wrong: 0.000104379

Data Source: BioPlex

EMILIN1

Tbio

Novelty: 0.02550566

p_int: 0.999410701

p_ni: 0.000015257

p_wrong: 0.000574042

Data Source: BioPlex

NPM2

Tbio

Novelty: 0.03674672

p_int: 0.946090388

p_ni: 0.010658789

p_wrong: 0.043250823

Score: 0.199

Data Source: BioPlex,STRINGDB

GAPDHS

Tbio

Family: Enzyme

Novelty: 0.00885959

p_int: 0.873589688

p_ni: 0.126409018

p_wrong: 0.000001294

Data Source: BioPlex

ZMAT2

Tbio

Novelty: 0.16771752

p_int: 0.756044079

p_ni: 0.211215063

p_wrong: 0.032740858

Score: 0.485

Data Source: BioPlex,STRINGDB

HACL1

Tbio

Family: Enzyme

Novelty: 0.05302548

p_int: 0.754571194

p_ni: 0.245428806

Score: 0.269

Data Source: BioPlex,STRINGDB

SH3GLB1

Tbio

Novelty: 0.0314974

Score: 0.711

Data Source: STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (6)

Components (4)

Processes (2)

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Items per page:

1 – 4 of 4

GO Term	Evidence	Assigned by
centriolar satellite	Inferred from Direct Assay (IDA)	UniProtKB

centrosome	Inferred from Direct Assay (IDA)	UniProtKB

ciliary basal body	Inferred from Direct Assay (IDA)	UniProtKB

centriole	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell

Disease Associations ()

No disease associations found

GWAS Traits (4)

Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
pulse pressure measurement	EFO_0005763	1	1	1		40.7

Hallux valgus	HP_0001822	1	1	0	2.1	31.4

balding measurement	EFO_0007825	1	1	1		5.8

intraocular pressure measurement	EFO_0004695	1	1	1		1.6

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
pulse pressure measurement	EFO_0005763	1		40.7

Hallux valgus	HP_0001822	0	2.1	31.4

balding measurement	EFO_0007825	1		5.8

intraocular pressure measurement	EFO_0004695	1		1.6

Beta Count

Odds Ratio

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UniProt Keyword

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No Header	No Header
Alternative splicing

Cell projection

Cilium biogenesis/degradation

Coiled coil

Complete proteome

Cytoplasm

Cytoskeleton

Polymorphism

Reference proteome

GWAS Trait

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IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID
Chimp	outer dense fiber of sperm tails 2 like	VGNC:8086	456991

Macaque	outer dense fiber of sperm tails 2 like		715193

Mouse	outer dense fiber of sperm tails 2-like	MGI:1098600	52184

Rat	outer dense fiber of sperm tails 2-like	RGD:1593831	685425

Dog	outer dense fiber of sperm tails 2 like	VGNC:44100	490179

Species	Name	OMA	EggNOG	Inparanoid
Chimp	outer dense fiber of sperm tails 2 like

Macaque	outer dense fiber of sperm tails 2 like

Mouse	outer dense fiber of sperm tails 2-like

Rat	outer dense fiber of sperm tails 2-like

Dog	outer dense fiber of sperm tails 2 like

Publication Statistics

PubMed Score 1.82

PubMed score by year

PubTator Score 0.50

PubTator score by year

Related Publications

Text Mined References (6)

Items per page:

0 of 0

PMID	Year	Title