KIF26A
Kinesin-like protein KIF26A
Protein Summary
Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity).
- ENST00000423312
- ENSP00000388241
- ENSG00000066735
- KIAA1236
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.98 | ||
cell line | 0.65 | ||
transcription factor binding site profile | 0.55 | ||
cellular component | 0.5 | ||
gene perturbation | 0.47 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.16 (req: < 5)
Gene RIFs: 0 (req: <= 3)
Antibodies: 80 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.16 (req: >= 5)
Gene RIFs: 0 (req: > 3)
Antibodies: 80 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (157)
Nearest Tclin Targets
Pathways (11)
Reactome (11)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | COPI-dependent Golgi-to-ER retrograde traffic | ||||
Reactome | Factors involved in megakaryocyte development and platelet production | ||||
Reactome | Golgi-to-ER retrograde transport | ||||
Reactome | Hemostasis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
COPI-dependent Golgi-to-ER retrograde traffic | ||||
Factors involved in megakaryocyte development and platelet production | ||||
Golgi-to-ER retrograde transport | ||||
Hemostasis | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (3)
Components (3)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (13)
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
amino acid measurement | 2 | 3 | 5 | 96.2 | |||||
asparagine measurement | 1 | 1 | 1 | 86.5 | |||||
platelet crit | 1 | 1 | 1 | 66.8 | |||||
platelet count | 1 | 1 | 1 | 60.2 | |||||
smoking status measurement | 1 | 1 | 1 | 56 | |||||
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
amino acid measurement | 5 | 96.2 | |||||
asparagine measurement | 1 | 86.5 | |||||
platelet crit | 1 | 66.8 | |||||
platelet count | 1 | 60.2 | |||||
smoking status measurement | 1 | 56 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | kinesin family member 26A | VGNC:12824 | 453197 | |||||
Mouse | MGI:2447072 | 668303 | ||||||
Rat | RGD:1307957 | 314473 | ||||||
Dog | kinesin family member 26A | VGNC:50541 | 490875 | |||||
Horse | kinesin family member 26A | VGNC:19412 | 100060810 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | kinesin family member 26A | |||||
Mouse | ||||||
Rat | ||||||
Dog | kinesin family member 26A | |||||
Horse | kinesin family member 26A | |||||
Publication Statistics
PubMed Score 6.16
PubMed score by year
PubTator Score 0.84
PubTator score by year
Related Publications
Text Mined References (5)
Items per page:
0 of 0
PMID | Year | Title |
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