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Tbio
KIF26A
Kinesin-like protein KIF26A

Protein Summary
Description
Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000423312
  • ENSP00000388241
  • ENSG00000066735

Symbol
  • KIAA1236
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
cell line
0.65
transcription factor binding site profile
0.55
cellular component
0.5
gene perturbation
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.16   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 80   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.16   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (157)
DYNC1I1
Tbio
Novelty:  0.12175372
Score:  0.937
Data Source:  STRINGDB
DYNC1LI2
Tbio
Novelty:  0.17381295
Score:  0.935
Data Source:  STRINGDB
DYNC1I2
Tbio
Novelty:  0.00228615
Score:  0.93
Data Source:  STRINGDB
DYNC1H1
Tbio
Novelty:  0.0098543
Score:  0.928
Data Source:  STRINGDB
KIF20A
Tchem
Novelty:  0.01640924
Score:  0.927
Data Source:  STRINGDB
KLC1
Tbio
Novelty:  0.00653484
Score:  0.926
Data Source:  STRINGDB
KIFAP3
Tbio
Novelty:  0.01902437
Score:  0.925
Data Source:  STRINGDB
KIF4A
Tbio
Novelty:  0.00888393
Score:  0.922
Data Source:  STRINGDB
KIF3A
Tbio
Novelty:  0.00555124
Score:  0.921
Data Source:  STRINGDB
KIF19
Tbio
Novelty:  0.16131415
Score:  0.921
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Golgi-to-ER retrograde transport
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
COPI-dependent Golgi-to-ER retrograde traffic
Factors involved in megakaryocyte development and platelet production
Golgi-to-ER retrograde transport
Hemostasis
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
amino acid measurement
2
3
5
96.2
asparagine measurement
1
1
1
86.5
platelet crit
1
1
1
66.8
platelet count
1
1
1
60.2
smoking status measurement
1
1
1
56
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
amino acid measurement
5
96.2
asparagine measurement
1
86.5
platelet crit
1
66.8
platelet count
1
60.2
smoking status measurement
1
56
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 26A
VGNC:12824
453197
Mouse
MGI:2447072
668303
Rat
RGD:1307957
314473
Dog
kinesin family member 26A
VGNC:50541
490875
Horse
kinesin family member 26A
VGNC:19412
100060810
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 26A
Mouse
Rat
Dog
kinesin family member 26A
Horse
kinesin family member 26A
Publication Statistics
PubMed Score 6.16
PubMed score by year
PubTator Score 0.84
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title