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Tbio
HEG1
Protein HEG homolog 1

Protein Summary
Description
Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity May act through the stabilization of endothelial cell junctions.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311127
  • ENSP00000311502
  • ENSG00000173706

Symbol
  • KIAA1237
  • HEG
  • MST112
  • MSTP112
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
PubMedID
0.82
transcription factor binding site profile
0.73
kinase perturbation
0.71
microRNA
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.86   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 18   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.86   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 18   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (33)
1 – 10 of 33
KRIT1
Tbio
Novelty:  0.00454953
p_int:  0.999954476
p_ni:  0.000045524
p_wrong:  1e-9
Score:  0.993
Data Source:  BioPlex,STRINGDB
LGALS3
Tchem
Novelty:  0.00032754
p_int:  0.99969419
p_ni:  0.000305809
Score:  0.16
Data Source:  BioPlex,STRINGDB
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.998805876
p_ni:  0.001194124
Data Source:  BioPlex
RAP1B
Tbio
Family:  Enzyme
Novelty:  0.00627538
Score:  0.975
Data Source:  STRINGDB
CCM2
Tbio
Novelty:  0.00785958
Score:  0.87
Data Source:  STRINGDB
RAP1A
Tchem
Family:  Enzyme
Novelty:  0.00375413
Score:  0.86
Data Source:  STRINGDB
PASK
Tchem
Family:  Kinase
Novelty:  0.14004084
Score:  0.71
Data Source:  STRINGDB
PTPRZ1
Tchem
Family:  Enzyme
Novelty:  0.00518159
Score:  0.643
Data Source:  STRINGDB
SIGLEC1
Tbio
Novelty:  0.00369952
Score:  0.636
Data Source:  STRINGDB
PDCD10
Tbio
Novelty:  0.00683934
Score:  0.612
Data Source:  STRINGDB
Gene Ontology Terms (27)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
2
2
2
70.4
reticulocyte measurement
2
2
2
66.6
visceral adipose tissue measurement
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
2
70.4
reticulocyte measurement
2
66.6
visceral adipose tissue measurement
1
31.4
Find similar targets by:
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heart development protein with EGF like domains 1
VGNC:7065
460648
Mouse
MGI:1924696
77446
Rat
RGD:1564641
689710
Dog
heart development protein with EGF like domains 1
VGNC:41647
488015
Cow
heart development protein with EGF like domains 1
VGNC:29803
511689
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heart development protein with EGF like domains 1
Mouse
Rat
Dog
heart development protein with EGF like domains 1
Cow
heart development protein with EGF like domains 1
Publication Statistics
PubMed Score 28.86
PubMed score by year
PubTator Score 6.22
PubTator score by year