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Tbio
RIMKLB
Beta-citrylglutamate synthase B

Protein Summary
Description
Catalyzes the synthesis of beta-citryl-L-glutamate and N-acetyl-L-aspartyl-L-glutamate. Beta-citryl-L-glutamate is synthesized more efficiently than N-acetyl-L-aspartyl-L-glutamate.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357529
  • ENSP00000350136
  • ENSG00000166532
  • ENST00000535829
  • ENSP00000445863
  • ENST00000538135
  • ENSP00000440943
  • ENST00000544257
  • ENSP00000438004
  • ENST00000619374
  • ENSP00000483871

Symbol
  • FAM80B
  • KIAA1238
  • NAAGS
  • FAM80B
  • NAAGS-I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
microRNA
0.89
protein domain
0.85
transcription factor perturbation
0.74
histone modification site profile
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.53   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.53   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
4
6
91.1
reticulocyte measurement
3
3
3
89.8
mean platelet volume
1
1
1
55.2
mean corpuscular volume
1
1
1
45.2
Calcium channel blocker use measurement
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
91.1
reticulocyte measurement
3
89.8
mean platelet volume
1
55.2
mean corpuscular volume
1
45.2
Calcium channel blocker use measurement
1
39.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal modification protein rimK like family member B
VGNC:48993
735860
Macaque
ribosomal modification protein rimK like family member B
722261
Mouse
MGI:1918325
108653
Rat
RGD:2318342
100362344
Dog
ribosomal modification protein rimK like family member B
VGNC:45581
486698
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal modification protein rimK like family member B
Macaque
ribosomal modification protein rimK like family member B
Mouse
Rat
Dog
ribosomal modification protein rimK like family member B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9ULI2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Glutamate and glutamine metabolism (R-HSA-8964539)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glutamate and glutamine metabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Glutamate and glutamine metabolism
Metabolism
Metabolism of amino acids and derivatives
Gene Ontology Terms (8)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (40)
1 – 10 of 40
NAT8L
Tbio
Family:  Enzyme
Novelty:  0.01761988
Score:  0.972
Data Source:  STRINGDB
FOLH1
Tclin
Family:  Enzyme
Novelty:  0.0002861
Score:  0.961
Data Source:  STRINGDB
ASPA
Tbio
Family:  Enzyme
Novelty:  0.02701619
Score:  0.926
Data Source:  STRINGDB
RIMKLA
Tdark
Family:  Enzyme
Novelty:  0.30213465
Score:  0.905
Data Source:  STRINGDB
CS
Tbio
Family:  Enzyme
Novelty:  0.00154214
Score:  0.871
Data Source:  STRINGDB
IDH3B
Tbio
Family:  Enzyme
Novelty:  0.04326765
Score:  0.837
Data Source:  STRINGDB
IDH3A
Tbio
Family:  Enzyme
Novelty:  0.02027198
Score:  0.837
Data Source:  STRINGDB
IDH3G
Tbio
Family:  Enzyme
Novelty:  0.04861242
Score:  0.837
Data Source:  STRINGDB
ACLY
Tclin
Family:  Enzyme
Novelty:  0.00114812
Score:  0.83
Data Source:  STRINGDB
OGDHL
Tbio
Family:  Enzyme
Novelty:  0.05079572
Score:  0.817
Data Source:  STRINGDB
Publication Statistics
PubMed Score  5.53

PubMed score by year
PubTator Score  1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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