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Tchem
ATAD2B
ATPase family AAA domain-containing protein 2B

Protein Summary
Description
The protein encoded by this gene belongs to the AAA ATPase family. This family member includes an N-terminal bromodomain. It has been found to be localized to the nucleus, partly to replication sites, consistent with a chromatin-related function. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000238789
  • ENSP00000238789
  • ENSG00000119778

Symbol
  • KIAA1240
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
histone modification site profile
0.87
protein domain
0.85
transcription factor binding site profile
0.82
disease perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.39   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 21   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.39   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 21   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (192)
UBXN7
Tbio
Novelty:  0.07437638
Score:  0.868
Data Source:  STRINGDB
UFD1
Tbio
Novelty:  0.01230296
Score:  0.859
Data Source:  STRINGDB
NPLOC4
Tbio
Novelty:  0.01690434
Score:  0.841
Data Source:  STRINGDB
PSMD6
Tbio
Family:  Enzyme
Novelty:  0.04419339
Score:  0.826
Data Source:  STRINGDB
PSMD8
Tbio
Family:  Enzyme
Novelty:  0.03053455
Score:  0.816
Data Source:  STRINGDB
BTAF1
Tbio
Novelty:  0.01586704
Score:  0.808
Data Source:  STRINGDB
PSMD13
Tbio
Family:  Enzyme
Novelty:  0.04204417
Score:  0.784
Data Source:  STRINGDB
PSMD2
Tbio
Family:  Enzyme
Novelty:  0.03530762
Score:  0.784
Data Source:  STRINGDB
TP53BP1
Tbio
Family:  Epigenetic
Novelty:  0.00131256
Score:  0.779
Data Source:  STRINGDB
POLR2A
Tbio
Family:  Enzyme
Novelty:  0.00188323
Score:  0.771
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (50)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
7
11
99
reticulocyte count
7
7
17
98.5
lymphocyte count
3
4
4
98.3
appendicular lean mass
3
5
10
98.2
HbA1c measurement
4
7
8
96.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
11
99
reticulocyte count
17
98.5
lymphocyte count
4
98.3
appendicular lean mass
10
98.2
HbA1c measurement
8
96.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase family, AAA domain containing 2B
VGNC:176
470325
Macaque
ATPase family, AAA domain containing 2B
703529
Mouse
MGI:2444798
320817
Dog
ATPase family, AAA domain containing 2B
VGNC:38202
475681
Horse
ATPase family, AAA domain containing 2B
VGNC:15604
100071677
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase family, AAA domain containing 2B
Macaque
ATPase family, AAA domain containing 2B
Mouse
Dog
ATPase family, AAA domain containing 2B
Horse
ATPase family, AAA domain containing 2B
Publication Statistics
PubMed Score 2.39
PubMed score by year
PubTator Score 2.13
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title