Tchem ATAD2B ATPase family AAA domain-containing protein 2B

Protein Summary

Description

The protein encoded by this gene belongs to the AAA ATPase family. This family member includes an N-terminal bromodomain. It has been found to be localized to the nucleus, partly to replication sites, consistent with a chromatin-related function. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• Q9ULI0
• B9ZVQ5
• Q6ZNA6
• Q8N9E7

Gene Name

• ATAD2B

Ensembl ID

• ENST00000238789
• ENSP00000238789
• ENSG00000119778

Symbol

• KIAA1240

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
histone modification site profile	0.87
protein domain	0.85
transcription factor binding site profile	0.82
disease perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Hydrolase / Atpase Family Aaa Domain-containing Protein 2b

DTO Classes

Protein / Epigenetic Regulator / Reader / Bromodomain / Atpase Family Aaa Domain-containing Protein 2b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.54   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 21   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.54   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 21   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0