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Tbio
LRFN2
Leucine-rich repeat and fibronectin type-III domain-containing protein 2

Protein Summary
Description
Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A. May play a role in redistributing DLG4 to the cell periphery (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338305
  • ENSP00000345985
  • ENSG00000156564

Symbol
  • KIAA1246
  • SALM1
  • SALM1
  • FIGLER2
  • KIAA1246
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
PubMedID
0.94
histone modification site profile
0.64
cell line
0.62
phenotype
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.88   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.88   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
2
2
97.6
visceral adipose tissue measurement
1
1
1
93
mathematical ability
2
2
2
81.1
4
2
3
1
78.3
1
1
0
1.2
76.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
97.6
visceral adipose tissue measurement
1
93
mathematical ability
2
81.1
3
1
78.3
0
1.2
76.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat and fibronectin type III domain containing 2
VGNC:12648
462672
Macaque
leucine rich repeat and fibronectin type III domain containing 2
719621
Mouse
MGI:1917780
70530
Rat
RGD:1311831
316205
Dog
leucine rich repeat and fibronectin type III domain containing 2
VGNC:42761
481785
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat and fibronectin type III domain containing 2
Macaque
leucine rich repeat and fibronectin type III domain containing 2
Mouse
Rat
Dog
leucine rich repeat and fibronectin type III domain containing 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9ULH4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Reactome
Synaptic adhesion-like molecules
Name
Explore in Pharos
Explore in Source
Neuronal System
Protein-protein interactions at synapses
Synaptic adhesion-like molecules
Gene Ontology Terms (8)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (72)
1 – 10 of 72
ACAD11
Tbio
Family: Enzyme
Novelty: 0.22908145
p_int: 0.9986961
p_ni: 0.0013039
Data Source: BioPlex
LRFN4
Tbio
Novelty: 0.12511571
p_int: 0.990112728
p_ni: 0.001542993
p_wrong: 0.008344279
Data Source: BioPlex,Reactome
PNPT1
Tbio
Family: Enzyme
Novelty: 0.00339969
p_int: 0.978060725
p_ni: 0.02193927
p_wrong: 5e-9
Data Source: BioPlex
SNX17
Tbio
Novelty: 0.03960737
p_int: 0.774334708
p_ni: 0.225660502
p_wrong: 0.00000479
Data Source: BioPlex
VANGL1
Tbio
Novelty: 0.00968008
p_int: 0.767007312
p_ni: 0.232992687
p_wrong: 1e-9
Data Source: BioPlex
DLG4
Tchem
Novelty: 0.00057285
Score: 0.992
Data Source: Reactome,STRINGDB
DLG3
Tbio
Novelty: 0.01196565
Score: 0.978
Data Source: Reactome,STRINGDB
GRIN1
Tclin
Family: IC
Novelty: 0.0011807
Score: 0.971
Data Source: Reactome,STRINGDB
DLG1
Tbio
Novelty: 0.0050926
Score: 0.962
Data Source: Reactome,STRINGDB
GRIN2A
Tclin
Family: IC
Novelty: 0.00060035
Score: 0.956
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  14.88

PubMed score by year
PubTator Score  5.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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