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Tbio
KIDINS220
Kinase D-interacting substrate of 220 kDa

Protein Summary
Description
Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. This gene encodes a transmembrane protein that is preferentially expressed in the nervous system where it controls neuronal cell survival, differentiation into exons and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256707
  • ENSP00000256707
  • ENSG00000134313
  • ENST00000319688
  • ENSP00000319947
  • ENST00000473731
  • ENSP00000418974

Symbol
  • ARMS
  • KIAA1250
  • ARMS
  • SINO
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.96
interacting protein
0.89
co-expressed gene
0.82
biological process
0.8
cell line
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.93   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 246   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.93   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
skin aging measurement
1
1
1
6.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
skin aging measurement
1
6.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kinase D-interacting substrate 220
VGNC:6393
459010
Macaque
kinase D interacting substrate 220
693522
Mouse
MGI:1924730
77480
Rat
RGD:619949
116478
Dog
kinase D interacting substrate 220
VGNC:42378
475657
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kinase D-interacting substrate 220
Macaque
kinase D interacting substrate 220
Mouse
Rat
Dog
kinase D interacting substrate 220
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9ULH0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (99)
ARMS-mediated activation (R-HSA-170984)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ARMS-mediated activation
Reactome
Prolonged ERK activation events
Reactome
Signal Transduction
Reactome
Signaling by NTRK1 (TRKA)
Reactome
Signaling by NTRKs
Name
Explore in Pharos
Explore in Source
ARMS-mediated activation
Prolonged ERK activation events
Signal Transduction
Signaling by NTRK1 (TRKA)
Signaling by NTRKs
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (95)
1 – 10 of 95
XPR1
Tbio
Novelty: 0.00735578
p_int: 0.999996554
p_ni: 0.000003446
Score: 0.828
Data Source: BioPlex,STRINGDB
FGFR2
Tclin
Family: Kinase
Novelty: 0.00066613
p_int: 0.999826899
p_ni: 0.000173101
Score: 0.315
Data Source: BioPlex,STRINGDB
CGRRF1
Tdark
Novelty: 0.49690187
p_int: 0.998384229
p_ni: 0.001615771
Score: 0.154
Data Source: BioPlex,STRINGDB
FAF2
Tbio
Novelty: 0.03048598
p_int: 0.992162565
p_ni: 0.007837435
Data Source: BioPlex
TMEM9
Tbio
Novelty: 0.06916197
p_int: 0.989557371
p_ni: 0.010442629
Data Source: BioPlex
VSIG1
Tbio
Novelty: 0.15442611
p_int: 0.968958611
p_ni: 0.031041389
Data Source: BioPlex
VSTM1
Tbio
Novelty: 0.08630646
p_int: 0.960503895
p_ni: 0.039496105
Data Source: BioPlex
MRAP2
Tbio
Novelty: 0.0420503
p_int: 0.959714361
p_ni: 0.040285639
Data Source: BioPlex
B4GAT1
Tbio
Family: Enzyme
Novelty: 0.14959923
p_int: 0.942998707
p_ni: 0.057001293
Data Source: BioPlex
EVA1C
Tbio
Novelty: 0.45928677
p_int: 0.936190103
p_ni: 0.063809897
Data Source: BioPlex
Publication Statistics
PubMed Score  57.93

PubMed score by year
PubTator Score  22.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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