Tbio CCPG1 Cell cycle progression protein 1

Protein Summary

Description

Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42 (By similarity). May be involved in cell cycle regulation.

Uniprot Accession IDs

• Q9ULG6
• A0PJH3
• A8K9T0
• O14712
• Q05DG4
• Q5U5S7
• Q8IYV8
• Q9BY53
• Q9HA17

Gene Name

• CCPG1

Ensembl ID

• ENST00000310958
• ENSP00000311656
• ENSG00000260916
• ENST00000425574
• ENSP00000415128
• ENST00000442196
• ENSP00000403400
• ENST00000569205
• ENSP00000454456

Symbol

• CCP8
• CPR8
• KIAA1254
• CPR8

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.91
ligand (protein) perturbation	0.83
histone modification site profile	0.81
transcription factor perturbation	0.8
virus perturbation	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.03   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 64   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.03   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0