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Tclin
KCNH3
Potassium voltage-gated channel subfamily H member 3

Protein Summary
Description
Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly. The protein encoded by this gene is a voltage-gated potassium channel alpha subunit predominantly expressed in the forebrain. Studies in mice have found that cognitive function increases when this gene is knocked out. In humans, the encoded protein has been shown to be capable of binding glycoprotein 120 of the human immunodeficiency virus type 1 (HIV-1) envelope. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257981
  • ENSP00000257981
  • ENSG00000135519

Symbol
  • KIAA1282
  • BEC1
  • ELK2
  • Kv12.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
protein domain
0.99
PubMedID
0.55
histone modification site profile
0.53
transcription factor
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.01   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.01   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 69
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (53)
KCNAB3
Tbio
Family:  IC
Novelty:  0.10128237
Score:  0.975
Data Source:  STRINGDB
KCNAB2
Tbio
Family:  IC
Novelty:  0.01752175
Score:  0.94
Data Source:  STRINGDB
KCNAB1
Tbio
Family:  IC
Novelty:  0.01413705
Score:  0.934
Data Source:  STRINGDB
ELK1
Tbio
Family:  TF
Novelty:  0.21670414
Score:  0.805
Data Source:  STRINGDB
KCNK4
Tbio
Family:  IC
Novelty:  0.01173058
Score:  0.801
Data Source:  STRINGDB
KCNQ3
Tclin
Family:  IC
Novelty:  0.00547886
Score:  0.784
Data Source:  STRINGDB
SNPH
Tbio
Novelty:  0.02572001
Score:  0.742
Data Source:  STRINGDB
OPCML
Tbio
Novelty:  0.01569352
Score:  0.726
Data Source:  STRINGDB
CACNB1
Tbio
Family:  IC
Novelty:  0.06568749
Score:  0.714
Data Source:  STRINGDB
KCNF1
Tclin
Family:  IC
Novelty:  0.00797195
Score:  0.711
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Potassium Channels
Reactome
Voltage gated Potassium channels
Name
Explore in Pharos
Explore in Source
Neuronal System
Potassium Channels
Voltage gated Potassium channels
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
2
2
71.8
self reported educational attainment
2
2
2
53.1
intelligence
2
2
2
40.5
alcohol consumption measurement
1
1
1
33.1
bone density
1
1
2
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
71.8
self reported educational attainment
2
53.1
intelligence
2
40.5
alcohol consumption measurement
1
33.1
bone density
2
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily H member 3
VGNC:8426
451880
Macaque
potassium voltage-gated channel subfamily H member 3
710838
Mouse
MGI:1341723
16512
Rat
RGD:71070
27150
Dog
potassium voltage-gated channel subfamily H member 3
VGNC:49915
486556
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily H member 3
Macaque
potassium voltage-gated channel subfamily H member 3
Mouse
Rat
Dog
potassium voltage-gated channel subfamily H member 3
Publication Statistics
PubMed Score 17.01
PubMed score by year
PubTator Score 3.77
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Text