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Tbio
INTU
Protein inturned

Protein Summary
Description
Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (PubMed:27158779).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335251
  • ENSP00000334003
  • ENSG00000164066
  • ENST00000503626
  • ENSP00000426287
  • ENST00000503952
  • ENSP00000421995

Symbol
  • KIAA1284
  • PDZD6
  • PDZK6
  • INT
  • OFD17
  • PDZD6
  • PDZK6
  • SRTD20
  • CPLANE4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.72
tissue
0.67
histone modification site profile
0.64
phenotype
0.58
kinase perturbation
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.55   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.55   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
1
1
1
35
mean reticulocyte volume
1
1
1
6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
1
35
mean reticulocyte volume
1
6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inturned planar cell polarity protein
VGNC:754
471302
Macaque
inturned planar cell polarity protein
709967
Mouse
MGI:2443752
380614
Dog
inturned planar cell polarity protein
VGNC:42059
607233
Horse
inturned planar cell polarity protein
VGNC:19098
100071919
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inturned planar cell polarity protein
Macaque
inturned planar cell polarity protein
Mouse
Dog
inturned planar cell polarity protein
Horse
inturned planar cell polarity protein
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9ULD6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Hedgehog 'off' state (R-HSA-5610787)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hedgehog 'off' state
Reactome
Signal Transduction
Reactome
Signaling by Hedgehog
Name
Explore in Pharos
Explore in Source
Hedgehog 'off' state
Signal Transduction
Signaling by Hedgehog
Gene Ontology Terms (20)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (73)
1 – 10 of 73
CPLANE2
Tdark
Family:  Enzyme
Novelty:  0.04171418
p_int:  0.999999991
p_ni:  8e-9
p_wrong:  1e-9
Score:  0.953
Data Source:  BioPlex,STRINGDB
FUZ
Tbio
Novelty:  0.03001976
p_int:  0.999999986
p_ni:  1.1e-8
p_wrong:  3e-9
Score:  0.985
Data Source:  BioPlex,STRINGDB
SUZ12
Tbio
Novelty:  0.00402353
p_int:  0.999924958
p_ni:  0.000075042
Score:  0.4
Data Source:  BioPlex,STRINGDB
APPBP2
Tbio
Novelty:  0.14742368
p_int:  0.998568328
p_ni:  0.001431669
p_wrong:  3e-9
Data Source:  BioPlex
EED
Tchem
Novelty:  0.00615758
p_int:  0.99645493
p_ni:  0.003545065
p_wrong:  5e-9
Score:  0.734
Data Source:  BioPlex,STRINGDB
EME1
Tbio
Family:  Enzyme
Novelty:  0.017415
p_int:  0.985418357
p_ni:  0.012455803
p_wrong:  0.002125839
Score:  0.181
Data Source:  BioPlex,STRINGDB
RPTOR
Tbio
Novelty:  0.00119147
p_int:  0.984333436
p_ni:  0.015666561
p_wrong:  3e-9
Data Source:  BioPlex
FNTB
Tclin
Family:  Enzyme
Novelty:  0.07434994
p_int:  0.97682806
p_ni:  0.023171831
p_wrong:  1.09e-7
Data Source:  BioPlex
AP2M1
Tbio
Novelty:  0.00769368
p_int:  0.975923339
p_ni:  0.024076661
Data Source:  BioPlex
NCAPG
Tbio
Novelty:  0.01777557
p_int:  0.973404329
p_ni:  0.026595671
Score:  0.193
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  39.55

PubMed score by year
PubTator Score  27.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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