BRPF3
Bromodomain and PHD finger-containing protein 3
Protein Classes
Protein Summary
Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.
- ENST00000339717
- ENSP00000345419
- ENSG00000096070
- ENST00000357641
- ENSP00000350267
- ENST00000534694
- ENSP00000434501
- KIAA1286
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.99 | ||
transcription factor binding site profile | 0.78 | ||
histone modification site profile | 0.75 | ||
tissue sample | 0.67 | ||
microRNA | 0.64 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.33 (req: < 5)
Gene RIFs: 0 (req: <= 3)
Antibodies: 76 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.33 (req: >= 5)
Gene RIFs: 0 (req: > 3)
Antibodies: 76 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 4
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (4)
1 – 4 of 4
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
hemoglobin measurement | 1 | 1 | 1 | 3.3 | |||||
hematocrit | 1 | 1 | 1 | 2.4 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
hemoglobin measurement | 1 | 3.3 | |||||
hematocrit | 1 | 2.4 | |||||
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | bromodomain and PHD finger containing 3 | VGNC:2650 | 462645 | |||||
Macaque | bromodomain and PHD finger containing 3 | 718997 | ||||||
Mouse | MGI:2146836 | 268936 | ||||||
Rat | RGD:1306868 | 309647 | ||||||
Dog | bromodomain and PHD finger containing 3 | VGNC:38534 | 481762 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | bromodomain and PHD finger containing 3 | |||||
Macaque | bromodomain and PHD finger containing 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | bromodomain and PHD finger containing 3 | |||||
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (13)
Reactome (13)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 13
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Chromatin modifying enzymes | ||||
Reactome | Chromatin organization | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | HATs acetylate histones | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Chromatin modifying enzymes | ||||
Chromatin organization | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
HATs acetylate histones | ||||
Gene Ontology Terms (6)
Functions (1)
Components (3)
Processes (2)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (54)
1 – 10 of 54
MEAF6
Novelty: 0.0914094
p_int: 0.99999996
p_ni: 3.4e-8
p_wrong: 5e-9
Score: 0.995
Data Source: BioPlex,STRINGDB
KAT7
Family: TF; Epigenetic
Novelty: 0.01783137
p_int: 0.999999956
p_ni: 3.3e-8
p_wrong: 1.2e-8
Score: 0.99
Data Source: BioPlex,STRINGDB
KAT6A
Family: Epigenetic
Novelty: 0.00478771
Score: 0.988
Data Source: STRINGDB
KAT6B
Family: Epigenetic
Novelty: 0.00361345
Score: 0.986
Data Source: STRINGDB
ING5
Family: Epigenetic
Novelty: 0.03585867
Score: 0.974
Data Source: STRINGDB
EP300
Family: Epigenetic
Novelty: 0.00055009
Score: 0.927
Data Source: STRINGDB
CHD3
Family: Epigenetic
Novelty: 0.00657278
Score: 0.922
Data Source: STRINGDB
BRD7
Family: Epigenetic
Novelty: 0.01820848
Score: 0.922
Data Source: STRINGDB
HDAC1
Family: Epigenetic
Novelty: 0.00065244
Score: 0.917
Data Source: STRINGDB
CHD4
Family: Epigenetic
Novelty: 0.00826969
Score: 0.915
Data Source: STRINGDB
Publication Statistics
PubMed Score 6.33
PubMed score by year
PubTator Score 0.77
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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