Tchem BRPF3 Bromodomain and PHD finger-containing protein 3

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Bromodomain And Phd Finger-containing Protein 3

Protein / Nucleic Acid Binding / Bromodomain And Phd Finger-containing Protein 3

Protein Summary

Description

Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.

Uniprot Accession IDs

• Q9ULD4
• A6ND56
• A6NJE2
• B7ZLN5
• E7EX85
• Q17RB6
• Q5R3K8

Gene Name

• BRPF3

Ensembl ID

• ENST00000339717
• ENSP00000345419
• ENSG00000096070
• ENST00000357641
• ENSP00000350267
• ENST00000534694
• ENSP00000434501

Symbol

• KIAA1286

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
transcription factor binding site profile	0.78
histone modification site profile	0.75
tissue sample	0.67
microRNA	0.64

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.74   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 76   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.74   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (11)

Explore Active Ligands

1 – 10 of 11

CHEMBL4449894

BRPF3Tchem Epigenetic

Kd : 6.9

CHEMBL3590408

BRPF3Tchem Epigenetic

Ki : 6.1

NI-57

BRPF3Tchem Epigenetic

Kd : 6.39

CHEMBL3774575

BRPF3Tchem Epigenetic

Kd : 7.57

CHEMBL4102050

BRPF3Tchem Epigenetic

Kd : 6.03

CHEMBL4103077

BRPF3Tchem Epigenetic

IC50 : 6.72

CHEMBL4076056

BRPF3Tchem Epigenetic

IC50 : 6

OF-1

BRPF3Tchem Epigenetic

Kd : 5.61999989

CHEMBL4069412

BRPF3Tchem Epigenetic

Ki : 7

CHEMBL4059962

BRPF3Tchem Epigenetic

IC50 : 6.55

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
hemoglobin measurement	EFO_0004509	1	1	1		13.6
hematocrit	EFO_0004348	1	1	1		12.1
BMI-adjusted waist circumference	EFO_0007789	1	1	1		3.8

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
hemoglobin measurement	EFO_0004509	1		13.6
hematocrit	EFO_0004348	1		12.1
BMI-adjusted waist circumference	EFO_0007789	1		3.8

Reset Zoom  Beta Count   Odds Ratio

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	bromodomain and PHD finger containing 3	VGNC:2650	462645
Macaque	bromodomain and PHD finger containing 3		718997
Mouse	bromodomain and PHD finger containing, 3	MGI:2146836	268936
Rat	bromodomain and PHD finger containing, 3	RGD:1306868	309647
Dog	bromodomain and PHD finger containing 3	VGNC:38534	481762

Species	Name	OMA	EggNOG	Inparanoid
Chimp	bromodomain and PHD finger containing 3
Macaque	bromodomain and PHD finger containing 3
Mouse	bromodomain and PHD finger containing, 3
Rat	bromodomain and PHD finger containing, 3
Dog	bromodomain and PHD finger containing 3

Protein Structure (1 Structure, 1 AlphaFold Model)

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Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9ULD4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (13)

Reactome (13)

Chromatin modifying enzymes (R-HSA-3247509)

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1 – 5 of 13

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Chromatin modifying enzymes	238 targets	R-HSA-3247509
Reactome	Chromatin organization	238 targets	R-HSA-4839726
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	HATs acetylate histones	107 targets	R-HSA-3214847

Name	Explore in Pharos	Explore in Source
Chromatin modifying enzymes	238 targets	R-HSA-3247509
Chromatin organization	238 targets	R-HSA-4839726
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
HATs acetylate histones	107 targets	R-HSA-3214847

Gene Ontology Terms (6)

Functions (1)

Components (3)

Processes (2)

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Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (54)

Explore Interacting Targets

1 – 10 of 54

• See Interactions on String-DB

MEAF6

Tbio

Novelty:  0.0914094

p_int:  0.99999996

p_ni:  3.4e-8

p_wrong:  5e-9

Score:  0.995

Data Source:  BioPlex,STRINGDB

KAT7

Tbio

Family:  TF; Epigenetic

Novelty:  0.01783137

p_int:  0.999999956

p_ni:  3.3e-8

p_wrong:  1.2e-8

Score:  0.99

Data Source:  BioPlex,STRINGDB

KAT6A

Tchem

Family:  Epigenetic

Novelty:  0.00478771

Score:  0.988

Data Source:  STRINGDB

KAT6B

Tchem

Family:  Epigenetic

Novelty:  0.00361345

Score:  0.986

Data Source:  STRINGDB

ING5

Tbio

Family:  Epigenetic

Novelty:  0.03585867

Score:  0.974

Data Source:  STRINGDB

EP300

Tchem

Family:  Epigenetic

Novelty:  0.00055009

Score:  0.927

Data Source:  STRINGDB

CHD3

Tbio

Family:  Epigenetic

Novelty:  0.00657278

Score:  0.922

Data Source:  STRINGDB

BRD7

Tchem

Family:  Epigenetic

Novelty:  0.01820848

Score:  0.922

Data Source:  STRINGDB

HDAC1

Tclin

Family:  Epigenetic

Novelty:  0.00065244

Score:  0.917

Data Source:  STRINGDB

CHD4

Tchem

Family:  Epigenetic

Novelty:  0.00826969

Score:  0.915

Data Source:  STRINGDB

Publication Statistics

PubMed Score  6.74

PubMed score by year

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PubTator Score  0.77

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Bromodomain
Chromatin regulator
Complete proteome
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted waist circumference
hematocrit
hemoglobin measurement

MGI Phenotype Find Similar Targets

No Header	No Header
homeostasis/metabolism phenotype
mortality/aging