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Tchem
BRPF3
Bromodomain and PHD finger-containing protein 3

Protein Summary
Description
Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339717
  • ENSP00000345419
  • ENSG00000096070
  • ENST00000357641
  • ENSP00000350267
  • ENST00000534694
  • ENSP00000434501

Symbol
  • KIAA1286
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
transcription factor binding site profile
0.78
histone modification site profile
0.75
tissue sample
0.67
microRNA
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.33   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.33   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
1
1
1
3.3
hematocrit
1
1
1
2.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
1
3.3
hematocrit
1
2.4
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
bromodomain and PHD finger containing 3
VGNC:2650
462645
Macaque
bromodomain and PHD finger containing 3
718997
Mouse
MGI:2146836
268936
Rat
RGD:1306868
309647
Dog
bromodomain and PHD finger containing 3
VGNC:38534
481762
Species
Name
OMA
EggNOG
Inparanoid
Chimp
bromodomain and PHD finger containing 3
Macaque
bromodomain and PHD finger containing 3
Mouse
Rat
Dog
bromodomain and PHD finger containing 3
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (13)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Gene expression (Transcription)
Generic Transcription Pathway
HATs acetylate histones
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (54)
1 – 10 of 54
MEAF6
Tbio
Novelty: 0.0914094
p_int: 0.99999996
p_ni: 3.4e-8
p_wrong: 5e-9
Score: 0.995
Data Source: BioPlex,STRINGDB
KAT7
Tbio
Family: TF; Epigenetic
Novelty: 0.01783137
p_int: 0.999999956
p_ni: 3.3e-8
p_wrong: 1.2e-8
Score: 0.99
Data Source: BioPlex,STRINGDB
KAT6A
Tbio
Family: Epigenetic
Novelty: 0.00478771
Score: 0.988
Data Source: STRINGDB
KAT6B
Tbio
Family: Epigenetic
Novelty: 0.00361345
Score: 0.986
Data Source: STRINGDB
ING5
Tbio
Family: Epigenetic
Novelty: 0.03585867
Score: 0.974
Data Source: STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00055009
Score: 0.927
Data Source: STRINGDB
CHD3
Tbio
Family: Epigenetic
Novelty: 0.00657278
Score: 0.922
Data Source: STRINGDB
BRD7
Tchem
Family: Epigenetic
Novelty: 0.01820848
Score: 0.922
Data Source: STRINGDB
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00065244
Score: 0.917
Data Source: STRINGDB
CHD4
Tbio
Family: Epigenetic
Novelty: 0.00826969
Score: 0.915
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.33

PubMed score by year
PubTator Score  0.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer