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Tchem
PADI1
Protein-arginine deiminase type-1

Protein Summary
Description
Catalyzes the deimination of arginine residues of proteins. This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375471
  • ENSP00000364620
  • ENSG00000142623
  • ENST00000631074
  • ENSP00000485803
  • ENSG00000281459

Symbol
  • PAD1
  • PDI1
  • PDI
  • PAD1
  • PDI1
  • HPAD10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
small molecule perturbation
0.62
cell type or tissue
0.57
disease perturbation
0.56
transcription factor
0.52


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.88   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.88   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
4
4
4
93
vitamin D measurement
4
4
4
93
hair shape measurement
1
1
1
69.8
hair shape measurement
1
1
1
69.8
basophil percentage of leukocytes
1
1
1
66.3
Items per page:
1 – 5 of 12
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
4
93
vitamin D measurement
4
93
hair shape measurement
1
69.8
hair shape measurement
1
69.8
basophil percentage of leukocytes
1
66.3
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peptidyl arginine deiminase 1
VGNC:11595
469177
Mouse
MGI:1338893
18599
Rat
RGD:3287
54282
Dog
peptidyl arginine deiminase 1
VGNC:44234
608443
Horse
peptidyl arginine deiminase 1
VGNC:21127
100049961
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peptidyl arginine deiminase 1
Mouse
Rat
Dog
peptidyl arginine deiminase 1
Horse
peptidyl arginine deiminase 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9ULC6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (27)
1 – 10 of 27
STAP2
Tbio
Novelty:  0.00375696
p_int:  0.999999972
p_ni:  2.8e-8
Score:  0.692
Data Source:  BioPlex,STRINGDB
PADI3
Tchem
Family:  Enzyme
Novelty:  0.01110139
p_int:  0.999870215
p_ni:  0.000129785
Score:  0.439
Data Source:  BioPlex,STRINGDB
TCHH
Tbio
Novelty:  0.00303837
Score:  0.649
Data Source:  STRINGDB
FLG
Tbio
Novelty:  0.00072986
Score:  0.581
Data Source:  STRINGDB
CRACR2B
Tbio
Novelty:  1.05982042
Score:  0.565
Data Source:  STRINGDB
IVL
Tbio
Novelty:  0.00147892
Score:  0.56
Data Source:  STRINGDB
TRIM3
Tbio
Novelty:  0.0188159
Score:  0.528
Data Source:  STRINGDB
DOCK1
Tbio
Novelty:  0.00867391
Score:  0.522
Data Source:  STRINGDB
TMEM35A
Tdark
Novelty:  0.25101021
Score:  0.519
Data Source:  STRINGDB
SPAG8
Tbio
Novelty:  0.06962141
Score:  0.499
Data Source:  STRINGDB
Publication Statistics
PubMed Score  75.88

PubMed score by year
PubTator Score  821.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer