Tchem ACSL5 Long-chain-fatty-acid--CoA ligase 5

Protein Summary

Description

Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells. The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9ULC5
• A6GV77
• D3DRB3
• Q6UX44
• Q9UIU4

Gene Name

• ACSL5

Ensembl ID

• ENST00000354273
• ENSP00000346223
• ENSG00000197142
• ENST00000354655
• ENSP00000346680
• ENST00000356116
• ENSP00000348429
• ENST00000393081
• ENSP00000376796
• ENST00000433418
• ENSP00000403647

Symbol

• ACS5
• FACL5
• ACS2
• ACS5
• FACL5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.98
hub protein	0.96
kinase perturbation	0.88
transcription factor perturbation	0.88
molecular function	0.86

Protein Classes

PANTHER Classes

Protein / Ligase / Long-chain-fatty-acid--coa Ligase 5

DTO Classes

Protein / Enzyme / Ligase / Long-chain-fatty-acid--coa Ligase 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.1   (req: < 5)

Gene RIFs: 39   (req: <= 3)

Antibodies: 234   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.1   (req: >= 5)

Gene RIFs: 39   (req: > 3)

Antibodies: 234   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1