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Tchem
ACSL5
Long-chain-fatty-acid--CoA ligase 5

Protein Classes
Protein Summary
Description
Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells. The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354273
  • ENSP00000346223
  • ENSG00000197142
  • ENST00000354655
  • ENSP00000346680
  • ENST00000356116
  • ENSP00000348429
  • ENST00000393081
  • ENSP00000376796
  • ENST00000433418
  • ENSP00000403647

Symbol
  • ACS5
  • FACL5
  • ACS2
  • ACS5
  • FACL5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
hub protein
0.96
kinase perturbation
0.88
transcription factor perturbation
0.88
molecular function
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.4   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 234   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.4   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 234   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
gilteritinib
Rendered image for gilteritinib
Active Ligands (1)
1 – 1 of 1
cediranib
Rendered image for cediranib
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
6
97.1
mathematical ability
4
2
4
78.2
4
2
0
1.1
71.4
apolipoprotein A 1 measurement
1
1
1
63.7
high density lipoprotein cholesterol measurement
1
1
1
61.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
6
97.1
mathematical ability
4
78.2
0
1.1
71.4
apolipoprotein A 1 measurement
1
63.7
high density lipoprotein cholesterol measurement
1
61.4
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA synthetase long chain family member 5
VGNC:8880
450739
Macaque
acyl-CoA synthetase long chain family member 5
696404
Mouse
MGI:1919129
433256
Rat
RGD:69402
94340
Dog
acyl-CoA synthetase long chain family member 5
VGNC:37535
477820
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA synthetase long chain family member 5
Macaque
acyl-CoA synthetase long chain family member 5
Mouse
Rat
Dog
acyl-CoA synthetase long chain family member 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9ULC5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (179)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Fatty acyl-CoA biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Synthesis of very long-chain fatty acyl-CoAs
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Fatty acyl-CoA biosynthesis
Metabolism
Metabolism of lipids
Synthesis of very long-chain fatty acyl-CoAs
Protein-Protein Interactions (130)
1 – 10 of 130
ACOX2
Tbio
Family:  Enzyme
Novelty:  0.02942359
Score:  0.965
Data Source:  STRINGDB
ACOX1
Tchem
Family:  Enzyme
Novelty:  0.00473427
Score:  0.959
Data Source:  STRINGDB
ACADL
Tbio
Family:  Enzyme
Novelty:  0.0298212
Score:  0.948
Data Source:  STRINGDB
ELOVL6
Tchem
Novelty:  0.00817818
Score:  0.944
Data Source:  STRINGDB
FASN
Tchem
Family:  Enzyme
Novelty:  0.00142172
Score:  0.942
Data Source:  STRINGDB
FADS2
Tbio
Family:  Enzyme
Novelty:  0.00180901
Score:  0.928
Data Source:  STRINGDB
ELOVL1
Tbio
Novelty:  0.03178348
Score:  0.91
Data Source:  STRINGDB
MGLL
Tchem
Family:  Enzyme
Novelty:  0.00196912
Score:  0.85
Data Source:  STRINGDB
LPL
Tchem
Family:  Enzyme
Novelty:  0.00057058
Score:  0.831
Data Source:  STRINGDB
HSD17B4
Tbio
Novelty:  0.00547499
Score:  0.8
Data Source:  STRINGDB
Publication Statistics
PubMed Score  119.40

PubMed score by year
PubTator Score  80.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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