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Tbio
RAB23
Ras-related protein Rab-23

Protein Summary
Description
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes. This gene encodes a small GTPase of the Ras superfamily. Rab proteins are involved in the regulation of diverse cellular functions associated with intracellular membrane traffi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317483
  • ENSP00000320413
  • ENSG00000112210
  • ENST00000468148
  • ENSP00000417610

Symbol
  • HSPC137
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
histone modification site profile
0.85
interacting protein
0.82
microRNA
0.76
biological process
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.19   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 259   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.19   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 259   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
4
4
79.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
79.5
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
RAB23, member RAS oncogene family
712860
Mouse
MGI:99833
19335
Rat
RGD:1306867
367242
Dog
RAB23, member RAS oncogene family
VGNC:45263
481854
Horse
RAB23, member RAS oncogene family
VGNC:22096
100070075
Species
Name
OMA
EggNOG
Inparanoid
Macaque
RAB23, member RAS oncogene family
Mouse
Rat
Dog
RAB23, member RAS oncogene family
Horse
RAB23, member RAS oncogene family
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9ULC3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
RAB geranylgeranylation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
RAB geranylgeranylation
Gene Ontology Terms (19)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (115)
1 – 10 of 115
POTEKP
Tdark
p_int: 0.999998455
p_ni: 0.000001438
p_wrong: 1.07e-7
Data Source: BioPlex
TREX1
Tbio
Family: Enzyme
Novelty: 0.87486677
p_int: 0.999971283
p_ni: 0.000028717
p_wrong: 1e-9
Score: 0.544
Data Source: BioPlex,STRINGDB
PLPPR1
Tdark
Family: Enzyme
Novelty: 0.38109551
p_int: 0.999970952
p_ni: 0.000028987
p_wrong: 6.1e-8
Score: 0.527
Data Source: BioPlex,STRINGDB
PCDHAC2
Tdark
Novelty: 0.28397695
p_int: 0.999787579
p_ni: 0.000210994
p_wrong: 0.000001428
Score: 0.173
Data Source: BioPlex,STRINGDB
GLI3
Tbio
Family: TF
Novelty: 0.00051217
Score: 0.962
Data Source: STRINGDB
GLI2
Tchem
Family: TF
Novelty: 0.00229126
Score: 0.951
Data Source: STRINGDB
CHM
Tbio
Family: Enzyme
Novelty: 0.00226278
Score: 0.928
Data Source: STRINGDB
RAB20
Tbio
Family: Enzyme
Novelty: 0.06768944
Score: 0.927
Data Source: STRINGDB
RAB18
Tbio
Family: Enzyme
Novelty: 0.01548795
Score: 0.927
Data Source: STRINGDB
RAB29
Tchem
Family: Enzyme
Novelty: 0.03751616
Score: 0.926
Data Source: STRINGDB
Publication Statistics
PubMed Score  68.19

PubMed score by year
PubTator Score  31.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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