Tbio EMCN Endomucin

Protein Summary

Description

Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix. EMCN is a mucin-like sialoglycoprotein that interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix (Kinoshita et al., 2001 [PubMed 11418125]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q9ULC0
• A8K716
• B4E347
• Q8NEY5
• Q8WWE7
• Q9NRM8

Gene Name

• EMCN

Ensembl ID

• ENST00000296420
• ENSP00000296420
• ENSG00000164035
• ENST00000305864
• ENSP00000304780
• ENST00000511970
• ENSP00000422432

Symbol

• EMCN2
• MUC14
• EMCN2
• MUC14

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.85
tissue sample	0.69
PubMedID	0.63
cell type or tissue	0.58
disease perturbation	0.56

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.16   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 188   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.16   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Gene Ontology Terms (3)

Components (3)

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
extracellular region	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell
integral component of membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
plasma membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell

Protein-Protein Interactions (41)

Explore Interacting Targets

1 – 10 of 41

• See Interactions on String-DB

OSGEP

Tbio

Family: Enzyme

Novelty: 0.01348632

Score: 0.937

Data Source: STRINGDB

SELL

Tchem

Novelty: 0.00035489

Score: 0.712

Data Source: STRINGDB

NTAN1

Tbio

Family: Enzyme

Novelty: 0.00549432

Score: 0.696

Data Source: STRINGDB

PECAM1

Tbio

Novelty: 0.00020273

Score: 0.696

Data Source: STRINGDB

ADGRL4

Tbio

Family: GPCR

Novelty: 0.00456769

Score: 0.688

Data Source: STRINGDB

MYCT1

Tbio

Novelty: 0.07073512

Score: 0.625

Data Source: STRINGDB

CDH5

Tbio

Novelty: 0.00096405

Score: 0.606

Data Source: STRINGDB

OCIAD2

Tbio

Novelty: 0.23622047

Score: 0.592

Data Source: STRINGDB

SYNPO2

Tbio

Novelty: 0.03724055

Score: 0.579

Data Source: STRINGDB

CD300LG

Tbio

Novelty: 0.12059672

Score: 0.576

Data Source: STRINGDB

Publication Statistics

PubMed Score  24.16

PubMed score by year

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PubTator Score  11.34

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MELLQVTILFLLPSICSSNSTGVLEAANNSLVVTTTKPSITTPNTESLQKNVVTPTTGTTPKGTITNELL

1-70

KMSLMSTATFLTSKDEGLKATTTDVRKNDSIISNVTVTSVTLPNAVSTLQSSKPKTETQSSIKTTEIPGS

70-140

VLQPDASPSKTGTLTSIPVTIPENTSQSQVIGTEGGKNASTSATSRSYSSIILPVVIALIVITLSVFVLV

140-210

GLYRMCWKADPGTPENGNDQPQSDKESVKLLTVKTISHESGEHSAQGKTKN

210-261

MELLQVTILFLLPSICSSNSTGVLEAANNSLVVTTTKPSITTPNTESLQKNVVTPTTGTTPKGTITNELLKMSLMSTATFLTSKDEGLKATTTDVRKNDSIISNVTVTSVTLPNAVSTLQSSKPKTETQSSIKTTEIPGSVLQPDASPSKTGTLTSIPVTIPENTSQSQVIGTEGGKNASTSATSRSYSSIILPVVIALIVITLSVFVLVGLYRMCWKADPGTPENGNDQPQSDKESVKLLTVKTISHESGEHSAQGKTKN

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Uniprot Keyword

Alternative splicing
Cell membrane
Complete proteome
Glycoprotein
Membrane
Phosphoprotein
Reference proteome
Secreted
Signal
Transmembrane