Tbio EMCN Endomucin

Protein Summary

Description

Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix. EMCN is a mucin-like sialoglycoprotein that interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix (Kinoshita et al., 2001 [PubMed 11418125]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q9ULC0
• A8K716
• B4E347
• Q8NEY5
• Q8WWE7
• Q9NRM8

Gene Name

• EMCN

Ensembl ID

• ENST00000296420
• ENSP00000296420
• ENSG00000164035
• ENST00000305864
• ENSP00000304780
• ENST00000511970
• ENSP00000422432

Symbol

• EMCN2
• MUC14
• EMCN2
• MUC14

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.85
tissue sample	0.69
PubMedID	0.63
cell type or tissue	0.58
disease perturbation	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.48   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 188   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.48   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0