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Tbio
CDH9
Cadherin-9

Protein Summary
Description
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000231021
  • ENSP00000231021
  • ENSG00000113100
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
protein domain
0.73
cell line
0.72
disease
0.58
cell type or tissue
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.51   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 158   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.51   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
CTNNB1
Tchem
Novelty:  0.0000744
Score:  0.955
Data Source:  STRINGDB
CDH10
Tbio
Novelty:  0.06137544
Score:  0.941
Data Source:  STRINGDB
CTNNA1
Tbio
Novelty:  0.00925774
Score:  0.94
Data Source:  STRINGDB
CDH15
Tbio
Novelty:  0.01904376
Score:  0.94
Data Source:  STRINGDB
CDH18
Tbio
Novelty:  0.09182754
Score:  0.939
Data Source:  STRINGDB
CDH7
Tbio
Novelty:  0.03451354
Score:  0.936
Data Source:  STRINGDB
CDH6
Tbio
Novelty:  0.01278517
Score:  0.936
Data Source:  STRINGDB
CTNND1
Tbio
Novelty:  0.00335459
Score:  0.93
Data Source:  STRINGDB
CDH17
Tbio
Novelty:  0.00035679
Score:  0.92
Data Source:  STRINGDB
CDH13
Tbio
Novelty:  0.00389516
Score:  0.92
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
Adherens junctions interactions (R-HSA-418990)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adherens junctions interactions
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Name
Explore in Pharos
Explore in Source
Adherens junctions interactions
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
2
2
83.2
mathematical ability
2
1
2
62.1
cognitive function measurement
3
1
3
61
wellbeing measurement
3
2
3
47.5
depressive symptom measurement
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
83.2
mathematical ability
2
62.1
cognitive function measurement
3
61
wellbeing measurement
3
47.5
depressive symptom measurement
1
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cadherin 9
VGNC:14500
461939
Macaque
cadherin 9
694989
Mouse
MGI:107433
12565
Rat
RGD:1308343
29163
Dog
cadherin 9
VGNC:39036
489245
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cadherin 9
Macaque
cadherin 9
Mouse
Rat
Dog
cadherin 9
Publication Statistics
PubMed Score 15.51
PubMed score by year
PubTator Score 9.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title