Protein Summary
Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their calcium-dependent interactions (via the ...more
- ENST00000404971
- ENSP00000385142
- ENSG00000179915
- ENST00000406316
- ENSP00000384311
- ENST00000625672
- ENSP00000485887
- KIAA0578
- PTHSL2
- SCZD17
- Hs.22998
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 339.81 (req: < 5)
Gene RIFs: 72 (req: <= 3)
Antibodies: 248 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 339.81 (req: >= 5)
Gene RIFs: 72 (req: > 3)
Antibodies: 248 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 32
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (277)
Nearest Tclin Targets
Pathways (6)
Reactome (5)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Extracellular matrix organization | ||||
Reactome | Neurexins and neuroligins | ||||
Reactome | Neuronal System | ||||
Reactome | Non-integrin membrane-ECM interactions | ||||
Reactome | Protein-protein interactions at synapses | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Extracellular matrix organization | ||||
Neurexins and neuroligins | ||||
Neuronal System | ||||
Non-integrin membrane-ECM interactions | ||||
Protein-protein interactions at synapses | ||||
Viral Interactions (0)
Gene Ontology Terms (47)
Functions (6)
Components (15)
Processes (26)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
chronotype measurement | 3 | 7 | 8 | 1.1 | 87.9 | ||||
body mass index | 3 | 3 | 6 | 87.5 | |||||
self reported educational attainment | 4 | 9 | 18 | 86.3 | |||||
smoking status measurement | 2 | 3 | 8 | 77.1 | |||||
visceral adipose tissue measurement | 1 | 2 | 4 | 60.8 | |||||
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
chronotype measurement | 8 | 1.1 | 87.9 | ||||
body mass index | 6 | 87.5 | |||||
self reported educational attainment | 18 | 86.3 | |||||
smoking status measurement | 8 | 77.1 | |||||
visceral adipose tissue measurement | 4 | 60.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (5)
1 – 5 of 5
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:1096391 | 18189 | ||||||
Horse | neurexin 1 | VGNC:20895 | 100052908 | |||||
Chicken | neurexin 1 | CGNC:49297 | 395398 | |||||
Zebrafish | ZDB-GENE-070206-1 | 565531 | ||||||
C. elegans | 179503 | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Horse | neurexin 1 | |||||
Chicken | neurexin 1 | |||||
Zebrafish | ||||||
C. elegans | ||||||
Publication Statistics
PubMed Score 339.81
PubMed score by year
PubTator Score 113.61
PubTator score by year
Related Publications
Text Mined References (123)
GeneRif Annotations (72)
Items per page:
0 of 0
PMID | Year | Title |
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