You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
DNPEP
Aspartyl aminopeptidase

Protein Classes
Protein Summary
Description
Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism. The protein encoded by this gene is an aminopeptidase which prefers acidic amino acids, and specifically favors aspartic acid over glutamic acid. It is thought to be a cytosolic protein involved in general metabolism of intracellular proteins. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273075
  • ENSP00000273075
  • ENSG00000123992

Symbol
  • ASPEP
  • DAP
  • DAP
  • ASPEP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor perturbation
0.97
co-expressed gene
0.94
histone modification site profile
0.8
transcription factor
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.39   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.39   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (53)
1 – 10 of 53
RAB11B
Tbio
Family: Enzyme
Novelty: 0.01072606
p_int: 0.999969764
p_ni: 0.000030174
p_wrong: 6.2e-8
Score: 0.199
Data Source: BioPlex,STRINGDB
RAB11A
Tbio
Family: Enzyme
Novelty: 0.00196791
p_int: 0.999890205
p_ni: 0.000109795
Score: 0.203
Data Source: BioPlex,STRINGDB
TAF15
Tbio
Novelty: 0.06055363
p_int: 0.999158423
p_ni: 0.000841577
Score: 0.269
Data Source: BioPlex,STRINGDB
MPPED1
Tdark
Family: Enzyme
Novelty: 0.23268698
p_int: 0.9943934
p_ni: 0.005606599
Score: 0.198
Data Source: BioPlex,STRINGDB
SCAF8
Tdark
Novelty: 0.24549918
p_int: 0.993048658
p_ni: 0.00694506
p_wrong: 0.000006282
Score: 0.199
Data Source: BioPlex,STRINGDB
ANKRD39
Tdark
p_int: 0.986171935
p_ni: 0.013828016
p_wrong: 4.9e-8
Data Source: BioPlex
DNAJB3
Tdark
p_int: 0.972378851
p_ni: 0.027621055
p_wrong: 9.4e-8
Data Source: BioPlex
LGALS13
Tbio
Novelty: 0.01009413
p_int: 0.959026035
p_ni: 0.040973692
p_wrong: 2.74e-7
Score: 0.199
Data Source: BioPlex,STRINGDB
MSMB
Tbio
Novelty: 0.00164465
p_int: 0.792510232
p_ni: 0.207456602
p_wrong: 0.000033166
Data Source: BioPlex
ENPEP
Tchem
Family: Enzyme
Novelty: 0.00116769
Score: 0.76
Data Source: STRINGDB
Publication Statistics
PubMed Score  33.39

PubMed score by year
PubTator Score  6.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer