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Tchem
DNPEP
Aspartyl aminopeptidase

Protein Summary
Description
Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism. The protein encoded by this gene is an aminopeptidase which prefers acidic amino acids, and specifically favors aspartic acid over glutamic acid. It is thought to be a cytosolic protein involved in general metabolism of intracellular proteins. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273075
  • ENSP00000273075
  • ENSG00000123992

Symbol
  • ASPEP
  • DAP
  • DAP
  • ASPEP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor perturbation
0.97
co-expressed gene
0.94
histone modification site profile
0.8
transcription factor
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.94   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.94   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (53)
RAB11B
Tbio
Family:  Enzyme
Novelty:  0.00557558
p_int:  0.999969764
p_ni:  0.000030174
p_wrong:  6.2e-8
Score:  0.199
Data Source:  BioPlex,STRINGDB
RAB11A
Tbio
Family:  Enzyme
Novelty:  0.00153551
p_int:  0.999890205
p_ni:  0.000109795
Score:  0.203
Data Source:  BioPlex,STRINGDB
TAF15
Tbio
Novelty:  0.0621505
p_int:  0.999158423
p_ni:  0.000841577
Score:  0.269
Data Source:  BioPlex,STRINGDB
MPPED1
Tdark
Family:  Enzyme
Novelty:  0.58103321
p_int:  0.9943934
p_ni:  0.005606599
Score:  0.198
Data Source:  BioPlex,STRINGDB
SCAF8
Tbio
Novelty:  0.1650699
p_int:  0.993048658
p_ni:  0.00694506
p_wrong:  0.000006282
Score:  0.199
Data Source:  BioPlex,STRINGDB
ANKRD39
Tdark
Novelty:  8.68843298
p_int:  0.986171935
p_ni:  0.013828016
p_wrong:  4.9e-8
Data Source:  BioPlex
DNAJB3
Tdark
p_int:  0.972378851
p_ni:  0.027621055
p_wrong:  9.4e-8
Data Source:  BioPlex
LGALS13
Tbio
Novelty:  0.00695816
p_int:  0.959026035
p_ni:  0.040973692
p_wrong:  2.74e-7
Score:  0.199
Data Source:  BioPlex,STRINGDB
MSMB
Tbio
Novelty:  0.00241546
p_int:  0.792510232
p_ni:  0.207456602
p_wrong:  0.000033166
Data Source:  BioPlex
ENPEP
Tchem
Family:  Enzyme
Novelty:  0.00112857
Score:  0.76
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
2
3
84.7
electrocardiography
1
1
82
75.9
reticulocyte count
2
1
2
71.3
mean reticulocyte volume
1
1
1
68.8
creatinine measurement
1
1
1
63.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
84.7
electrocardiography
82
75.9
reticulocyte count
2
71.3
mean reticulocyte volume
1
68.8
creatinine measurement
1
63.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aspartyl aminopeptidase
VGNC:168
459964
Macaque
aspartyl aminopeptidase
703180
Mouse
MGI:1278328
13437
Rat
RGD:1583848
301529
Dog
aspartyl aminopeptidase
VGNC:40038
478922
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aspartyl aminopeptidase
Macaque
aspartyl aminopeptidase
Mouse
Rat
Dog
aspartyl aminopeptidase
Publication Statistics
PubMed Score 41.94
PubMed score by year
PubTator Score 6.61
PubTator score by year
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Related Publications
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PMID
Year
Title