You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MYT1L
Myelin transcription factor 1-like protein

Protein Summary
Description
Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differentiation. In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs. Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B. The 5'-AAGTT-3' core motif is absent from the promoter of neural genes. This gene encodes a member of the zinc finger superfamily of transcription factors whose expression, thus far, has been found only in neuronal tissues. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399161
  • ENSP00000382114
  • ENSG00000186487
  • ENST00000407844
  • ENSP00000384219
  • ENST00000428368
  • ENSP00000396103
  • ENST00000647694
  • ENSP00000497722
  • ENST00000647738
  • ENSP00000497479
  • ENST00000648316
  • ENSP00000497870
  • ENST00000648928
  • ENSP00000497017
  • ENST00000649207
  • ENSP00000496986

Symbol
  • KIAA1106
  • NZF1
  • MRD39
  • myT1-L
  • ZC2H2C2
  • ZC2HC4B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
trait
0.86
transcription factor perturbation
0.68
disease
0.63
cell line
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.17   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 53   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.17   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
1
1
59.5
alcohol consumption measurement
1
1
1
51.4
gut microbiome measurement
1
1
0
5.5
27.5
risk-taking behaviour
1
1
1
9.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
59.5
alcohol consumption measurement
1
51.4
gut microbiome measurement
0
5.5
27.5
risk-taking behaviour
1
9.8
Gene Ontology Terms (14)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (71)
1 – 10 of 71
POU3F2
Tbio
Family: TF
Novelty: 0.00649458
Score: 0.863
Data Source: STRINGDB
ASCL1
Tbio
Family: TF
Novelty: 0.00274239
Score: 0.856
Data Source: STRINGDB
POU3F3
Tbio
Family: TF
Novelty: 0.00954977
Score: 0.776
Data Source: STRINGDB
NEUROD1
Tbio
Family: TF
Novelty: 0.00188624
Score: 0.767
Data Source: STRINGDB
NEUROD2
Tbio
Family: TF
Novelty: 0.01822347
Score: 0.758
Data Source: STRINGDB
PXDN
Tbio
Novelty: 0.00935722
Score: 0.693
Data Source: STRINGDB
SIN3B
Tbio
Novelty: 0.04097105
Score: 0.666
Data Source: STRINGDB
NEUROG2
Tbio
Family: TF
Novelty: 0.00489481
Score: 0.66
Data Source: STRINGDB
NKX2-2
Tbio
Family: TF
Novelty: 0.00608835
Score: 0.596
Data Source: STRINGDB
ZNF804A
Tbio
Novelty: 0.00751648
Score: 0.595
Data Source: STRINGDB
Publication Statistics
PubMed Score  57.17

PubMed score by year
PubTator Score  28.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: