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Tchem
TRPC5
Short transient receptor potential channel 5

Protein Summary
Description
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion. This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1) ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262839
  • ENSP00000262839
  • ENSG00000072315

Symbol
  • TRP5
  • TRP5
  • PPP1R159
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
molecular function
0.9
cell type or tissue
0.78
trait
0.75
gene perturbation
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 257.98   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 270   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 257.98   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 270   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 78
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
1
2
61.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
61.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transient receptor potential cation channel subfamily C member 5
VGNC:11612
465813
Macaque
transient receptor potential cation channel subfamily C member 5
707171
Mouse
MGI:109524
22067
Rat
RGD:619787
140933
Dog
transient receptor potential cation channel subfamily C member 5
VGNC:47870
492072
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transient receptor potential cation channel subfamily C member 5
Macaque
transient receptor potential cation channel subfamily C member 5
Mouse
Rat
Dog
transient receptor potential cation channel subfamily C member 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UL62-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Ion channel transport
Reactome
Netrin-1 signaling
Reactome
Role of second messengers in netrin-1 signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Ion channel transport
Netrin-1 signaling
Role of second messengers in netrin-1 signaling
Gene Ontology Terms (28)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (61)
1 – 10 of 61
AK6
Tbio
Family:  Kinase
Novelty:  0.173427
p_int:  0.965686066
p_ni:  0.034313934
Score:  0.282
Data Source:  BioPlex,STRINGDB
SEC24B
Tbio
Novelty:  0.01031644
p_int:  0.847135158
p_ni:  0.152864842
Score:  0.54
Data Source:  BioPlex,STRINGDB
TRPC1
Tbio
Family:  IC
Novelty:  0.00233677
Score:  0.948
Data Source:  Reactome,STRINGDB
TRPC3
Tchem
Family:  IC
Novelty:  0.00268752
Score:  0.941
Data Source:  Reactome,STRINGDB
TRPC6
Tchem
Family:  IC
Novelty:  0.00118598
Score:  0.94
Data Source:  Reactome,STRINGDB
PLCG1
Tchem
Family:  Enzyme
Novelty:  0.00110273
Score:  0.91
Data Source:  STRINGDB
TRPC7
Tchem
Family:  IC
Novelty:  0.0033307
Score:  0.908
Data Source:  Reactome,STRINGDB
STIM1
Tbio
Novelty:  0.00116516
Score:  0.813
Data Source:  STRINGDB
BMPR1B
Tchem
Family:  Kinase
Novelty:  0.00698763
Score:  0.806
Data Source:  STRINGDB
BMPR2
Tchem
Family:  Kinase
Novelty:  0.00155912
Score:  0.801
Data Source:  STRINGDB
Publication Statistics
PubMed Score  257.98

PubMed score by year
PubTator Score  139.25

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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