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Tchem
TAOK2
Serine/threonine-protein kinase TAO2

Protein Summary
Description
Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubul ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000279394
  • ENSP00000279394
  • ENSG00000149930
  • ENST00000308893
  • ENSP00000310094
  • ENST00000416441
  • ENSP00000393048
  • ENST00000543033
  • ENSP00000440336

Symbol
  • KIAA0881
  • MAP3K17
  • PSK
  • PSK1
  • PSK
  • PSK1
  • TAO1
  • TAO2
  • MAP3K17
  • PSK1-BETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
biological process
0.91
small molecule
0.89
cellular component
0.79
protein domain
0.73


Related Tools
Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.01   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.01   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL388978
chemical structure image
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
2
1
1.1
90.9
waist-hip ratio
1
1
1
88.4
high density lipoprotein cholesterol measurement
2
2
2
69.4
body mass index
1
1
1
62.2
body height
1
1
1
59.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
90.9
waist-hip ratio
1
88.4
high density lipoprotein cholesterol measurement
2
69.4
body mass index
1
62.2
body height
1
59.1
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TAO kinase 2
VGNC:13793
454033
Macaque
TAO kinase 2
707777
Mouse
MGI:1915919
381921
Rat
RGD:621590
64666
Dog
TAO kinase 2
VGNC:47103
489943
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TAO kinase 2
Macaque
TAO kinase 2
Mouse
Rat
Dog
TAO kinase 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UL54-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (42)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (47)
1 – 10 of 47
STK25
Tchem
Family: Kinase
Novelty: 0.03229688
p_int: 0.999992609
p_ni: 0.00000739
p_wrong: 1e-9
Score: 0.258
Data Source: BioPlex,STRINGDB
SLC39A8
Tbio
Family: Transporter
Novelty: 0.00923197
p_int: 0.999992227
p_ni: 0.000007773
Data Source: BioPlex
LTBR
Tbio
Novelty: 0.003823
p_int: 0.99999015
p_ni: 0.000009849
Data Source: BioPlex
PBXIP1
Tbio
Novelty: 0.15404864
p_int: 0.999707239
p_ni: 0.000232075
p_wrong: 0.000060686
Data Source: BioPlex
KCNS3
Tclin
Family: IC
Novelty: 0.05882087
p_int: 0.999538766
p_ni: 0.000461234
p_wrong: 1e-9
Data Source: BioPlex
NMUR2
Tchem
Family: GPCR
Novelty: 0.01353039
p_int: 0.999244941
p_ni: 0.000755058
p_wrong: 1e-9
Score: 0.175
Data Source: BioPlex,STRINGDB
FAM206A
Tbio
Novelty: 0.01675868
p_int: 0.998192849
p_ni: 0.00180715
p_wrong: 1e-9
Score: 0.239
Data Source: BioPlex,STRINGDB
PCDHB16
Tdark
Novelty: 0.67206411
p_int: 0.997371291
p_ni: 0.002628708
p_wrong: 1e-9
Score: 0.161
Data Source: BioPlex,STRINGDB
CLMN
Tbio
Novelty: 0.0822701
p_int: 0.996764891
p_ni: 0.003206012
p_wrong: 0.000029097
Data Source: BioPlex
TH
Tclin
Family: Enzyme
Novelty: 0.00025719
p_int: 0.994501834
p_ni: 0.005444694
p_wrong: 0.000053472
Score: 0.188
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  46.01

PubMed score by year
PubTator Score  164.89

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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