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Tbio
TMPRSS11E
Transmembrane protease serine 11E

Protein Summary
Description
Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305363
  • ENSP00000307519
  • ENSG00000087128

Symbol
  • DESC1
  • TMPRSS11E2
  • DESC1
  • TMPRSS11E2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
gene perturbation
0.71
cell line
0.5
cell type or tissue
0.46
tissue
0.44


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.92   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.92   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:3513175
243084
Pig
transmembrane protease serine 11E-like
100623351
Opossum
transmembrane protease, serine 11E
100618091
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Pig
transmembrane protease serine 11E-like
Opossum
transmembrane protease, serine 11E
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UL52-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (15)
1 – 10 of 15
SERPINA5
Tbio
Family: Enzyme
Novelty: 0.00152504
Score: 0.853
Data Source: STRINGDB
SERPINE1
Tchem
Novelty: 0.00017629
Score: 0.689
Data Source: STRINGDB
STEAP4
Tbio
Family: Enzyme
Novelty: 0.01926607
Score: 0.61
Data Source: STRINGDB
MUC20
Tbio
Novelty: 0.04645313
Score: 0.584
Data Source: STRINGDB
PCDH1
Tbio
Novelty: 0.0263888
Score: 0.583
Data Source: STRINGDB
MUC15
Tbio
Novelty: 0.02213624
Score: 0.581
Data Source: STRINGDB
OR5M3
Tdark
Family: oGPCR
Novelty: 6.79384824
Score: 0.536
Data Source: STRINGDB
SPINT1
Tbio
Family: Enzyme
Novelty: 0.00930324
Score: 0.476
Data Source: STRINGDB
ANO1
Tclin
Family: IC
Novelty: 0.00143722
Score: 0.459
Data Source: STRINGDB
CCPG1
Tbio
Novelty: 0.07685013
Score: 0.439
Data Source: STRINGDB
Publication Statistics
PubMed Score  13.92

PubMed score by year
PubTator Score  6.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer