Tbio TMPRSS11E Transmembrane protease serine 11E

Protein Summary

Description

Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position.

Uniprot Accession IDs

• Q9UL52
• A6NL71
• Q14DC8
• Q6UW31

Gene Name

• TMPRSS11E

Ensembl ID

• ENST00000305363
• ENSP00000307519
• ENSG00000087128

Symbol

• DESC1
• TMPRSS11E2
• DESC1
• TMPRSS11E2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
gene perturbation	0.71
cell line	0.5
cell type or tissue	0.46
tissue	0.44

Protein Classes

PANTHER Classes

Protein / ... / Serine Protease / Transmembrane Protease Serine 11e

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Transmembrane Protease Serine 11e

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.77   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 139   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.77   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0