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Tclin
HCN2
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

Protein Summary
Description
Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages (By similarity). The protein encoded by this gene is a hyperpolarization-activated cation channel involved in the generation of native pacemaker activity in the heart and in the brain. The encoded protein is activated by cAMP and can produce a fast, large current. Defects in this gene were noted as a possible cause of some forms of epilepsy. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251287
  • ENSP00000251287
  • ENSG00000099822

Symbol
  • BCNG2
  • BCNG2
  • HAC-1
  • BCNG-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.92
gene perturbation
0.65
phenotype
0.59
transcription factor
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.45   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 205   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.45   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 205   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
50.6
sex hormone-binding globulin measurement
3
2
3
41.9
cognitive function measurement
2
1
2
31.4
mathematical ability
1
1
1
21.5
pulse pressure measurement
1
1
1
14
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
50.6
sex hormone-binding globulin measurement
3
41.9
cognitive function measurement
2
31.4
mathematical ability
1
21.5
pulse pressure measurement
1
14
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1298210
15166
Rat
RGD:620689
114244
Cow
hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2
VGNC:29777
100297361
Opossum
hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 [Source:HGNC Symbol;Acc:HGNC:4846]
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2
Opossum
hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 [Source:HGNC Symbol;Acc:HGNC:4846]
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UL51-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
HCN channels (R-HSA-1296061)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
HCN channels
Reactome
Neuronal System
Reactome
Potassium Channels
Name
Explore in Pharos
Explore in Source
HCN channels
Neuronal System
Potassium Channels
Gene Ontology Terms (19)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (34)
1 – 10 of 34
HCN4
Tclin
Family:  IC
Novelty:  0.0021957
Score:  0.951
Data Source:  STRINGDB
HCN1
Tclin
Family:  IC
Novelty:  0.02529554
Score:  0.858
Data Source:  STRINGDB
CRTC1
Tbio
Novelty:  0.01177834
Score:  0.822
Data Source:  STRINGDB
DRD4
Tchem
Family:  GPCR
Novelty:  0.00099622
Score:  0.765
Data Source:  STRINGDB
FGF22
Tbio
Novelty:  0.0553003
Score:  0.755
Data Source:  STRINGDB
PEX5L
Tbio
Novelty:  0.01922466
Score:  0.743
Data Source:  STRINGDB
BCAM
Tbio
Novelty:  0.01697541
Score:  0.676
Data Source:  STRINGDB
TPSG1
Tchem
Family:  Enzyme
Novelty:  0.04752972
Score:  0.675
Data Source:  STRINGDB
MARCH7
Tbio
Family:  Enzyme
Novelty:  0.03358004
Score:  0.652
Data Source:  STRINGDB
HES7
Tbio
Family:  TF
Novelty:  0.02014919
Score:  0.563
Data Source:  STRINGDB
Publication Statistics
PubMed Score  45.45

PubMed score by year
PubTator Score  158.3

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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