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Tbio
TCFL5
Transcription factor-like 5 protein

Protein Summary
Description
Putative transcription factor. Isoform 3 may play a role in early spermatogenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335351
  • ENSP00000334294
  • ENSG00000101190

Symbol
  • CHA
  • E2BP1
  • CHA
  • Figlb
  • SOSF1
  • E2BP-1
  • bHLHe82
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.85
transcription factor perturbation
0.8
PubMedID
0.66
gene perturbation
0.62
transcription factor
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 242.44   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 186   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 242.44   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
1
1
1
59.8
monocyte count
1
1
1
48.5
age at menopause
1
1
1
42.3
diastolic blood pressure
1
1
1
24.5
creatinine measurement
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
1
59.8
monocyte count
1
48.5
age at menopause
1
42.3
diastolic blood pressure
1
24.5
creatinine measurement
1
17.8
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transcription factor like 5
VGNC:10003
458455
Mouse
MGI:2672878
277353
Rat
RGD:1305899
311715
Dog
transcription factor like 5
VGNC:49660
612441
Opossum
transcription factor like 5
100025661
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transcription factor like 5
Mouse
Rat
Dog
transcription factor like 5
Opossum
transcription factor like 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UL49-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (16)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (33)
1 – 10 of 33
MGAM
Tclin
Family:  Enzyme
Novelty:  0.00045865
Score:  0.731
Data Source:  STRINGDB
SLC9B1
Tbio
Family:  Transporter
Novelty:  0.01259992
Score:  0.711
Data Source:  STRINGDB
TAC1
Tbio
Novelty:  0.00006575
Score:  0.668
Data Source:  STRINGDB
PPFIBP2
Tbio
Novelty:  0.05704511
Score:  0.661
Data Source:  STRINGDB
MED31
Tbio
Family:  Enzyme
Novelty:  0.05516854
Score:  0.632
Data Source:  STRINGDB
FIGLA
Tbio
Family:  TF
Novelty:  0.02544697
Score:  0.626
Data Source:  STRINGDB
ZBTB25
Tbio
Family:  TF
Novelty:  0.0068423
Score:  0.606
Data Source:  STRINGDB
HSD17B12
Tbio
Family:  Enzyme
Novelty:  0.02200219
Score:  0.59
Data Source:  STRINGDB
MXD3
Tbio
Family:  TF
Novelty:  0.07436584
Score:  0.561
Data Source:  STRINGDB
VPS13A
Tbio
Novelty:  0.00581335
Score:  0.533
Data Source:  STRINGDB
Publication Statistics
PubMed Score  242.44

PubMed score by year
PubTator Score  177.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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