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Tbio
PSME2
Proteasome activator complex subunit 2

Protein Summary
Description
Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate reg ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216802
  • ENSP00000216802
  • ENSG00000100911
  • ENST00000645325
  • ENSP00000495790
  • ENSG00000284889

Symbol
  • PA28B
  • REGbeta
  • PA28beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
virus perturbation
1
biological process
0.98
kinase perturbation
0.97
PubMedID
0.87


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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.08   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 367   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.08   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 367   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proteasome activator subunit 2
VGNC:3333
744802
Macaque
proteasome activator subunit 2
715288
Mouse
MGI:1096365
19188
Rat
RGD:3430
29614
Dog
proteasome activator subunit 2
VGNC:45117
480258
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proteasome activator subunit 2
Macaque
proteasome activator subunit 2
Mouse
Rat
Dog
proteasome activator subunit 2
Pathways (154)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 151
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Gene Ontology Terms (15)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (240)
1 – 10 of 240
PSMB9
Tchem
Family: Enzyme
Novelty: 0.0016249
p_int: 0.999999889
p_ni: 1.11e-7
Score: 0.995
Data Source: BioPlex,STRINGDB
PSMB3
Tbio
Family: Enzyme
Novelty: 0.12791198
p_int: 0.999999826
p_ni: 1.74e-7
Score: 0.987
Data Source: BioPlex,STRINGDB
CTRL
Tchem
Family: Enzyme
Novelty: 0.00045495
p_int: 0.999998906
p_ni: 0.000001094
Score: 0.295
Data Source: BioPlex,STRINGDB
PSMA5
Tbio
Family: Enzyme
Novelty: 0.03862668
p_int: 0.999993148
p_ni: 0.000006852
Score: 0.994
Data Source: BioPlex,STRINGDB
PSMB7
Tbio
Family: Enzyme
Novelty: 0.06547657
p_int: 0.999991766
p_ni: 0.000008234
Score: 0.99
Data Source: BioPlex,STRINGDB
PSMB1
Tclin
Family: Enzyme
Novelty: 0.0255917
p_int: 0.999990031
p_ni: 0.000009969
Score: 0.987
Data Source: BioPlex,STRINGDB
PSMB2
Tclin
Family: Enzyme
Novelty: 0.06714761
p_int: 0.999978539
p_ni: 0.000021461
Score: 0.991
Data Source: BioPlex,STRINGDB
PSMB4
Tbio
Family: Enzyme
Novelty: 0.0376233
p_int: 0.99990094
p_ni: 0.00009906
Score: 0.989
Data Source: BioPlex,STRINGDB
PSMA1
Tclin
Family: Enzyme
Novelty: 0.013722
p_int: 0.999800837
p_ni: 0.000199163
Score: 0.988
Data Source: BioPlex,STRINGDB
SPPL2B
Tbio
Family: Enzyme
Novelty: 0.0274774
p_int: 0.995383994
p_ni: 0.004615953
p_wrong: 5.3e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  34.08

PubMed score by year
PubTator Score  17.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer