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Tbio
ZNF346
Zinc finger protein 346

Protein Summary
Description
Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity (PubMed:24521053). May bind to specific miRNA hairpins (PubMed:28431233). The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival. It plays a role in protecting neurons by inhibiting cell cycle re-entry via stimulation of p21 gene expression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358149
  • ENSP00000350869
  • ENSG00000113761
  • ENST00000503039
  • ENSP00000424495
  • ENST00000503425
  • ENSP00000421212

Symbol
  • JAZ
  • JAZ
  • Zfp346
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
kinase perturbation
0.84
cell type or tissue
0.66
virus perturbation
0.64
transcription factor binding site profile
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 560.05   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 276   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 560.05   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 276   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
2
3
94.2
3
1
1
1.1
74.3
2
2
0
1.1
71.1
Menorrhagia
1
1
0
1.1
61.9
self reported educational attainment
1
1
1
56.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
94.2
1
1.1
74.3
0
1.1
71.1
Menorrhagia
0
1.1
61.9
self reported educational attainment
1
56.5
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 346
VGNC:4232
462300
Macaque
zinc finger protein 346
698372
Mouse
MGI:1349417
26919
Rat
RGD:1308068
306765
Dog
zinc finger protein 346
VGNC:48706
612983
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 346
Macaque
zinc finger protein 346
Mouse
Rat
Dog
zinc finger protein 346
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UL40-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (9)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (73)
1 – 10 of 73
NAT2
Tbio
Family: Enzyme
Novelty: 0.00150849
p_int: 0.99999609
p_ni: 0.00000391
Score: 0.548
Data Source: BioPlex,STRINGDB
HIST1H1E
Tbio
Novelty: 0.01125284
p_int: 0.996632489
p_ni: 0.003367483
p_wrong: 2.8e-8
Data Source: BioPlex
ZNF777
Tdark
Family: TF
Novelty: 1.20195224
p_int: 0.988667865
p_ni: 0.011330452
p_wrong: 0.000001683
Data Source: BioPlex
ZNF512
Tbio
Family: TF
Novelty: 0.08783629
p_int: 0.979693278
p_ni: 0.020304404
p_wrong: 0.000002318
Data Source: BioPlex
RPS16
Tbio
Novelty: 0.00261983
p_int: 0.967036454
p_ni: 0.032927632
p_wrong: 0.000035914
Data Source: BioPlex
ELAVL2
Tbio
Novelty: 0.00370708
p_int: 0.959444312
p_ni: 0.040551813
p_wrong: 0.000003875
Data Source: BioPlex
CCDC59
Tbio
Novelty: 0.05894885
p_int: 0.932887286
p_ni: 0.067104549
p_wrong: 0.000008165
Data Source: BioPlex
RBMX2
Tbio
Novelty: 0.08867468
p_int: 0.916632402
p_ni: 0.022304838
p_wrong: 0.061062759
Data Source: BioPlex
HEATR3
Tbio
Novelty: 0.08367436
p_int: 0.885435775
p_ni: 0.114460017
p_wrong: 0.000104207
Data Source: BioPlex
ZKSCAN8
Tbio
Family: TF
Novelty: 0.17881042
p_int: 0.878840568
p_ni: 0.120840666
p_wrong: 0.000318767
Data Source: BioPlex
Publication Statistics
PubMed Score  560.05

PubMed score by year
PubTator Score  28.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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